Clinical trials: Saline
Nephropathy
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a defect in the tubular reabsorption of sodium, and therefore the ability to excrete a sodium load is diminished compared to healthy subjects.
- Trial name
- CASE (NCT01623661)
- Testing
- hypertonic saline
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Hip Pain
Comparison of Bacteriostatic Saline to Buffered Lidocaine for Ultrasound Guided Hip Joint Injection Local Anesthesia
The purpose of this study is to compare infiltration pain and anesthetic efficacy between lidocaine and Bacteriostatic saline (BS) for ultrasound (US) guided intraarticular hip injections.
- Trial name
- NCT02209272
- Testing
- bacteriostatic saline, buffered lidocaine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wound of Skin
Safety and Performance of SWIS in Superficial Wounds
This is an open, evaluator blinded, intra-comparative, randomized, non-inferiority investigation prior to CE mark to confirm safety and performance of the SWIS device when used as intended, i.e.
- Trial name
- NCT04771819
- Testing
- SWIS
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SoftOx Solutions AS
Wound Healing
Postoperative Care of Sutured Wounds
The primary objective of this study is to compare the efficacy of hydrogen peroxide versus normal saline in postoperative care of sutured wounds.
- Trial name
- NCT02383992
- Testing
- 3% H2O2 solution, 0.9% normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy
Study of Subcutaneous Hydration Enabled by Human Recombinant Hyaluronidase (Hylenex)
Randomized, double-blinded study that will evaluate the tolerability, safety, and flow rates of different solutions subcutaneously (SC) infused and preceded by human recombinant hyaluronidase (hylenex) 150 units.
- Trial name
- INFUSE-NSLR (NCT00656370)
- Testing
- recombinant human hyaluronidase
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Halozyme Therapeutics
Post-operative Pain, Vital Pulp Therapy
Compare the Impact of Sodium Hypochlorite and Saline Irrigation Protocols With and Without Cryotherapy on Post-operative Pain Following Pulpotomy in Permanent Mandibular Molar Teeth.
The aim of the present study will compare the impact of sodium hypochlorite and saline irrigation protocols with and without cryotherapy on post-operative pain following pulpotomy in permanent mandibular molar teeth.Will the use…
- Trial name
- NaOCl/VPT/MTA (NCT07764666)
- Testing
- VPT /pulpotomy, VPT/complete pulpotomy, vital pulp therapy /complete pulpotomy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Refaat Khalaf Ahmed
Postural Tachycardia Syndrome, Orthostatic Tachycardia
Acute Salt Handling in Orthostatic Intolerance
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control…
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
- Trial name
- NCT00581633
- Testing
- normal saline (0.9%)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dysphagia
Effects of 3% Sodium Chloride on Post-operative Dysphagia Following Anterior Cervical Spine Surgery
Post-operative dysphagia is a significant issue following anterior cervical spine surgery. The investigators are studying the effects of perioperative 3% sodium chloride, given over a period of 24 hours, on post-operative…
- Trial name
- NCT03677310
- Testing
- 3% Sodium Chloride, Normal Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Keratoconjunctivitis Sicca
Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points
To evaluate tear film stability of a market lubricant therapeutic eye drop versus saline when using Evaporometry and Interferometry in patients with a diagnosis of Keratoconjunctivitis Sicca (KCS).
- Trial name
- NCT00345241
- Testing
- Systane Ocular Drops (OTC)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postdural Puncture Headache, Post-Lumbar Puncture Headache
Incidence of Headache Following an Unintentional Dural Puncture
The purpose of this study is to evaluate the use of intrathecal morphine administration following an unintentional dural puncture, to decrease the incidence of post dural puncture headaches (PDPH) in obstetric patients.
- Conditions
- Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
- Trial name
- NCT01977898
- Testing
- Morphine, Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Wrinkle
Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate
This study was designed to investigate the effects of botulinum toxin type A injections diluted with the mixture of sodium bicarbonate (SB) and normal saline (NS) on pain reduction, onset of action and duration of action.
- Trial name
- NCT04579419
- Testing
- Sodium Bicarbonate, Normal Saline
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Unspecified Disorder of Nose and Nasal Sinuses
Immediate Effect of Proponent-Nasal-Spray on Unspecific Discomfort in the Nose
Investigation of the immediate effect on subjective relief of symptoms by Proponent - Nasal - Spray after a one time administration (following a single dose administration in each nostril) in an open, not randomised, non-blinded…
- Trial name
- NCT03251066
- Testing
- Proponent Nasal Spray
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- PRECLIN Biosystems AG
Lung Diseases
Evaluation of Regional Lung Deposition of Inhaled Saline Using the tPAD Device
Purpose: Characterize the depositional attributes of a specialized trans-nasal aerosol delivery device in healthy people using clinical measurements of mucociliary clearance.
- Trial name
- NCT03185650
- Testing
- tPAD Device, PARI LC Star Nebulizer
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Sinusitis
Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis
The purpose of this study is to the effect of squeezable bottle nasal irrigation device with syringe in children with sinusitis in symptom score and satisfaction to nasal irrigation
- Trial name
- NCT02191046
- Testing
- squeezable bottle, syringe 20 ml
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Surgical Blood Loss
To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to investigate whether the saline-coupled bipolar sealer compared to the unipolar electrocautery provides superior hemostasis in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- NCT03952546
- Testing
- Saline-coupled Bipolar Sealer, Unipolar electrocautery
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy
Evaluation of Pain Reduction in the Administration of Saline Injections by the Usage of Pneumatic Skin Flattening
Each participant will be administered 2 injections of saline - the first in the right gluteal area and the second in the left gluteal area. Both injections will be administered intra-muscularly by the same clinician.
- Trial name
- NCT00503087
- Testing
- Saline Injection, Pneumatic Skin Flattening (PSF)
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- PalJect Ltd.
Pain, Local Anesthesia for Peripheral Intravenous Catheterization
Local Anesthetics for Pain Reduction Prior to IV Line Placement
The purpose of this study is to compare the pain level felt by patients when receiving placement of a peripheral intravenous catheter (IV line) following the administration of a local anesthetic.
- Trial name
- NCT01759459
- Testing
- Lidocaine, Buffered Lidocaine, Bacteriostatic Normal Saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Elective Cesarean Section
The Clotting Effects of Pentastarch and Normal Saline in Obstetric Patients
Pregnant women are more likely to form clots than non-pregnant women as pregnancy increases the clotting factors present in the blood. This helps to prevent excess bleeding (hemorrhage) at the time of delivery.
- Trial name
- NCT00474162
- Testing
- Pentaspan®, Normal Saline
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hysteroscopy
Effectiveness of Warm Saline Distension Media on Relieving Pain in Office Hysteroscopy
The aim of the study is to compare the effectiveness of warm saline distension media versus room temperature saline distension media on relieving pain in office hysteroscopy .
- Trial name
- NCT03111563
- Testing
- Warm saline distension media in office hysteroscopy
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Wound Heal, Cesarean Section Complications
The Effect of Suturing Material on Scar Healing
We want to compare the effects of 2 suture materials (monofilament and multifilament) on healing of the uterine scar after a cesarean delivery.
- Conditions
- Wound Heal, Cesarean Section Complications, Cesarean Wound Disruption, Suture Related Complication
- Trial name
- NCT03968783
- Testing
- Monofilament suture, Multifilament suture
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University