Clinical trials: Saliva
Oral Health
Effect of Two Toothpastes on Bacteria in Saliva
This study investigated the ability of two zinc-containing toothpaste formulations (Zinc A and Zinc B) to reduce the level of bacteria in saliva in the two-hour period after their use, compared to the effect of rinsing with water…
- Trial name
- NCT03587428
- Testing
- Zinc-A toothpaste, Zinc-B toothpaste, Mineral water
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Covid19
COVID-19 Saliva Test Research Study
The objective of this study is to compare the Chronomics test against the NPS tests and protocol currently in use to demonstrate the efficacy of Chronomics' approach.
- Trial name
- NCT04531501
- Testing
- Saliva and NPS test
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chronomics Limited
Autism Spectrum Disorder, Developmental Delay
Validation of a Salivary miRNA Diagnostic Test for ASD
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months.
- Trial name
- NCT05418023
- Testing
- Salivary Collection, Adaptive Assessment, Medical and Demographic questionnaire
- Where
- 16 sites in United States
- Volunteers
- 6,604 people
- Sponsor
- Quadrant Biosciences Inc.
Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
Antiviral Activity of Oral Probiotics
The aim of this study is to test saliva samples obtained from healthy human participants for anti-viral activity after they have consumed S. salivarius probiotic in a powder format.
- Trial name
- NCT05374070
- Testing
- Streptococcus salivarius K12 Powder 1 Billion colony forming units /g), Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included, Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- John Hale
Saliva Altered
Salivary Flow Promoted by Sugar-Free Chewing Gum
This was a double-blind, single center in vivo salivary flow rate study. The objective was to compare a marketed sugar-free chewing gum to a clinically-tested sugar-free reference chewing gum, with regards to their ability to…
- Trial name
- NCT05447104
- Testing
- Mastication
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mars Wrigley
Fragile X Syndrome
Validation of Saliva in the Esoterix Genetic Laboratories Fragile X Assay
The purpose of this research is to determine if saliva samples can be used as an alternate sample type to test for fragile X. By using saliva instead of blood, it would be easier for patients to have fragile X testing.
- Trial name
- NCT01616589
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Esoterix Genetic Laboratories, LLC
Lung Cancer
Salivary Biomarkers for Non-small Cell Lung Cancer Detection
The investigators plan to recruit patients for a prospective study in patients in need of evaluation for lung lesions suspicious for cancer.
- Trial name
- NCT02294578
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- PeriRx
Covid19, Sars-CoV-2 Infection
Performance Study of SONA Saliva C-19 Rapid Test
The Sona Saliva C-19 Rapid Test is a bioassay intended for rapid point-of-care detection of the SARS-CoV-2 virus. Performance of the Sona Saliva C-19 Rapid Test assay will be assessed by comparison to a RT-PCR reference method
- Conditions
- Covid19, Sars-CoV-2 Infection, Corona Virus Infection
- Trial name
- NCT04877002
- Testing
- Sona Saliva C-19 Rapid Test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sona Nanotech Inc
Healthy Subjects
The Effect of Sensory-enhanced Beverages on Satiety Following Repeated Exposures
The study will be a 3-way crossover design: it will assess the impact of consuming a beverage enhanced with satiety-relevant properties on subjective ratings of appetite and on energy intake compared with a low energy version…
- Trial name
- NCT02097927
- Testing
- Mango-flavour beverage
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leatherhead Food Research
Healthy
Biomarkers in Saliva and Stool
To collect saliva and stool samples using the salimetrics swab and self-stool collection kit, process and store samples in a standardized manner.
- Trial name
- NCT03297008
- Testing
- No internvetion
- Where
- Singapore
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Covid-19
COVID-19 Tests: Nasopharyngeal Swab vs Saliva Collected With Salivette® Cortisol for Viral RNA Sampling for RT-qPCR
The main objective of the tests is to establish saliva collection with Salivette® Cortisol.
- Trial name
- NCT04599959
- Testing
- Sampling of SARS-CoV-2 RNA from nasopharyngeal swab specimen or saliva collected via Salivette Cortisol
- Where
- Mexico
- Volunteers
- 151 people
- Sponsor
- Boehringer Ingelheim
Endometriosis, Diagnosis
Analytical Evaluation of the Endotest® Diagnostic
This is an interventional with minimal risks and constraints (RIPH 2 in France), prospective, longitudinal, non-randomized, multicenter study.
- Trial name
- ENDORepro (NCT06072820)
- Testing
- Salivary Sampling
- Where
- 2 sites in France
- Sponsor
- ZIWIG
Covid19
Pilot Study to Evaluate Effect of CHX0.12/CPC 0.05 of SARS-CoV-2 Viral Load in COVID-19 Patients
Randomized, double-blind, placebo-controlled pilot study to evalaute viral load in saliva of COVID19+ patients using quantitative PCR, before and after use of active or placebo rinses
- Trial name
- NCT04563689
- Testing
- CHX0.12+CPC0.05 oral rinse (PerioAidActive Control)
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Dentaid SL
Oral Squamous Cell Carcinoma
Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer
The study is designed to measure salivary matrix metalloproteinase-1 (MMP-1) using the enzyme-linked immunosorbent assay (ELISA) we developed previously in patients with oral potentially malignant disorders (OPMD), oral squamous…
- Trial name
- NCT05049408
- Testing
- MMP-1 Enzyme Linked Immunosorbent assay (ELISA)
- Where
- 2 sites in Taiwan
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- S&T Biomed Co., Ltd.
Dehydration
Biomarkers for Noninvasive Assessment of Human Hydration
Low levels of dehydration (the loss of body water corresponding to 2% of the body weight), deteriorate physical and cognitive performance and may also be linked to a number of chronic diseases.
- Trial name
- NCT01507129
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Gaia Medical Institute
Myelodysplastic Syndromes(MDS)
Collection of Samples From Patients With MDS
The purpose of this study is to collect information and bone marrow, blood, saliva, cheek cells and skin to be used in the laboratory to assist the sponsor in identifying a new way of treating MDS.
- Trial name
- NCT03072498
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- PersImmune, Inc
Xerostomia Due to Hyposecretion of Salivary Gland, Diabetes Mellitus, Type 2
The Artificial Saliva Spray Reduces Xerostomia in Diabetes Type II
In diabetes Type II the xerostomia is a quite frequent symptom. In evaluating the activity of an artificial saliva spray compared to a water gel in patients with Diabetes Type II patients had to follow a three day treatment with…
- Trial name
- NCT03452085
- Testing
- artificial saliva spray (AS), maritime throat spray (TT)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Certmedica International GmbH
Plaque, Dental
Arginine Plaque Metabolism Pilot Clinical Study
Proof of concept clinical study to measure plaque metabolism and the prebiotic efficacy of arginine-containing toothpaste.
- Trial name
- NCT06954779
- Testing
- Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Sleep Problems
Assessment of the Pharmacokinetics of Circadin® in Children With Neurodevelopmental Disorders and Sleep Disturbances
There is increasing evidence that chronic sleep disorders in children with autism spectrum disorder (ASD), Angelman Syndrome (AS) and Smith-Magenis syndrome (SMS) are associated with disturbed melatonin secretion and melatonin…
- Trial name
- NCT01903681
- Testing
- Circadin 2 mg, Circadin 10 mg
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Healthy
Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria in Saliva and Bioaerosol Contamination
To evaluate the anti-bacterial, pre-procedural, clinical efficacy of Peroxyl mouthwash (1.5% hydrogen peroxide) in saliva and the reduction of bioaerosol contamination as compared to a matching placebo mouthwash (0.0% hydrogen…
- Trial name
- NCT04626778
- Testing
- Peroxyl Mouthwash
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive