Clinical trials: Saliva
SARS-CoV-2, COVID-19
The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts.
- Conditions
- SARS-CoV-2, COVID-19, Mouthwashes, Viral Load
- Trial name
- NCT04721457
- Testing
- Distilled Water, 1% Povidone Iodine (PVP-I), 1.5% Hydrogen Peroxide (H2O2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Saliva Altered
Salivary Flow Promoted by Sugar-Free Chewing Gum
This was a double-blind, single center in vivo salivary flow rate study. The objective was to compare a marketed sugar-free chewing gum to a clinically-tested sugar-free reference chewing gum, with regards to their ability to…
- Trial name
- NCT05447104
- Testing
- Mastication
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mars Wrigley
pH, Saliva
Carbonated Beverage Consumption in pH and Bacterial Proliferation
The objective of this research is to evaluate the oral modifications caused by different types of coke drinks (regular coke and diet coke).
- Conditions
- pH, Saliva, Dental Plaque
- Trial name
- pHSB (NCT05437874)
- Testing
- Natural Water
- Where
- Mexico
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Periodontal Diseases, Saliva Altered
The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke
Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated.
- Conditions
- Periodontal Diseases, Saliva Altered, Stroke
- Trial name
- NCT05394090
- Testing
- saliva stimulation
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Electrolyte Disturbance, Saliva Altered
Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity
Dental caries is the most prevalent infectious disease related to oral health.. Although significant advances have been made on a global front to prevent caries, studies show its incidence is on the rise making it one of the…
- Trial name
- NCT05245019
- Testing
- cardamom, fennel
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Heart Failure, Thirst
Using Saliva Stimulation to Immediately Improve Heart Failure Inpatient's Thirst Sensation
The purpose of this study is to Using saliva stimulation to immediately improve heart failure inpatient's thirst sensation.
- Conditions
- Heart Failure, Thirst, Saliva
- Trial name
- NCT05325983
- Testing
- lemonade ice cubes, water ice cubes
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- LI-JU Chen
Saliva Stimulated
A Stimulator of the Salivary Vibration of the Parotid Glands
Oral dryness causes significant health problems both functional (difficulty speaking, chewing and swallowing) and structural problems in teeth (increased number of infections) and oral mucosa.
- Trial name
- saliva (NCT05129111)
- Testing
- PHYSICAL VIBRATION OF THE PAROTID GLANDS
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
COVID19, Mouthwash
COVID-19: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses
Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission.
- Conditions
- COVID19, Mouthwash, Saliva
- Trial name
- BBCovid (NCT04352959)
- Testing
- mouthrinse with bêta-cyclodextrin and citrox, mouthrinse without bêta-cyclodextrin and citrox
- Where
- 4 sites in France
- Volunteers
- 176 people
- Sponsor
- Claude Bernard University
Vaginal Microbiome, Skin Microbiome
Integrated Genetic and Functional Analysis of the Female Microbiome in a Flemish Cohort
The aim of the project is to improve our knowledge on the stability and temporal dynamics of the Flemish female microbiome (vagina, skin and saliva) in relation to different lifestyle factors and environmental conditions and to…
- Conditions
- Vaginal Microbiome, Skin Microbiome, Saliva Microbiome
- Trial name
- Isala (NCT04319536)
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Saliva
The Effect of Chewing the Tapioca Pearls in Bubble Tea Drinks
Bubble tea drinks contain tea and tapioca pearls. Chewing tapioca pearls in bubble tea drinks may increase salivary components. Because of its proteins, inorganic components, and enzymes, saliva plays an important role in the…
- Trial name
- NCT04670341
- Testing
- chewing tapioca pearls in bubble tea drinks, drink tea without chewing tapioca pearls
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Sars-CoV2, RT-PCR
Detection of COVID-19 in Saliva Collection
Since December 2019, the world has faced a pandemic of COVID-19, an infectious disease caused by SARS-CoV-2, a virus that emerged in China.
- Conditions
- Sars-CoV2, RT-PCR, Saliva Collection, Nasopharyngeal Sample
- Trial name
- SALICOV (NCT04386551)
- Where
- France
- Volunteers
- 501 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer
Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial
Nasopharyngeal carcinoma (NPC) is the highest reported otorhinolaryngological malignancy reported in Malaysia affecting predominantly male adults between 40-60 years old [1, 2].
- Trial name
- NCT04491435
- Testing
- Summated Xerostomia Inventory, Sialometry
- Where
- Malaysia
- Volunteers
- 94 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
HDL Cholesterol, Preeclampsia
Identifying HDL Composition and Function in Preeclamptic and Normal Pregnancies
The study is design to assess if there is a correlation between diagnosis of preeclampsia and its severity to changes in HDL quality, in terms of composition and function and to determine whether preeclampsia-induced changes in…
- Conditions
- HDL Cholesterol, Preeclampsia, Saliva
- Trial name
- NCT02554604
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Hepcidin, Saliva
Assessement of Hepcidin in Saliva in Human Volunteers
Iron deficiency with or without anemia is considered the most widespread nutritional deficiency in the world. To diagnose iron deficiency anemia (hemoglobin and ferritin measurement), a venous blood sample is necessary.
- Trial name
- NCT03816813
- Testing
- blood and saliva sampling
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Swiss Federal Institute of Technology
Saliva Altered, Plaque
Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients
This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both…
- Trial name
- NCT03877705
- Testing
- Listerine ready tabs
- Where
- Egypt
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of most types of acidic and sweetened foods and beverages are known to reduce the pH of saliva and some of them…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-F (NCT03510962)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of most types of acidic and sweetened foods and beverages are known to reduce the pH of saliva and some of them…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-M (NCT03513575)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of acidic and sweetened food and beverage is known to reduce the salivary pH and some of them reduce it to…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-C (NCT03526770)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Xerostomia Due to Hyposecretion of Salivary Gland, pH
Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients
Xerostomia is defined as the subjective complaint of dry mouth. Symptoms of dry mouth may range from mild oral discomfort to significant oral disease that can compromise patients' health, dietary intake and quality of life.
- Conditions
- Xerostomia Due to Hyposecretion of Salivary Gland, pH, Saliva, Quality of Life
- Trial name
- Aqualief (NCT03612414)
- Testing
- Aqualief
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi dell'Insubria