Clinical trials: Saliva Microbiome
Dental Erosion
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive.
- Trial name
- NCT06171594
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Periodontitis
Microbiome and Proteome Mapping in Periodontitis
This study aimed to compare the microbiome and proteome profiles of saliva, serum and all periodontal sites in patients with periodontitis.
- Trial name
- NCT06675474
- Testing
- Clinical periodontal measurements, Saliva sampling, Serum Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Barrett Esophagus, Esophageal Adenocarcinoma
The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)
The purpose of this study is to prospectively collect and analyze clinical data and biospecimens from a cohort of 100 patients without BE (20), with non-dysplastic BE (40), or with BE and high grade dysplasia (HGD) or EAC (40).
- Trial name
- NCT05524844
- Testing
- Sample Collection, Endoscopy results, Dietary questionnaire
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Columbia University
Dental Erosion
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive.
- Trial name
- NCT06156618
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Colorectal Cancer, Tumor
Microbiome in Colorectal Cancer Onset and Progression
This is an observational study with the goal to improve the robustness of the scientific evidence linking Fusobacterium nucleatum (Fn) and/or other microorganisms to colorectal cancer (CRC) onset and/or progression.
- Conditions
- Colorectal Cancer, Tumor, CRC, GI Cancer
- Trial name
- NCT05368688
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Viome
Inflammatory Bowel Disease (IBD), Dysbiosis
Oral Microbiota Dysbiosis in IBD
This study aims to provide new insights into oral microbiota dysbiosis and IBD. Given the strong association between oral health, microbiome composition, and IBD, all participants will undergo an oral evaluation program conducted…
- Trial name
- MIBD (NCT06980818)
- Testing
- No intervention
- Where
- Portugal
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- ULS Viseu Dão Lafões
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu
Saliva Altered, Taste, Altered
Taste Perception, Salivary Proteins & the Oral Microbiome
Genetic differences in taste are believed to play an important role in food selection, especially for strong-tasting foods and beverages.
- Trial name
- NCT04107688
- Testing
- Control, CPE
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Vaginal Microbiome, Skin Microbiome
Integrated Genetic and Functional Analysis of the Female Microbiome in a Flemish Cohort
The aim of the project is to improve our knowledge on the stability and temporal dynamics of the Flemish female microbiome (vagina, skin and saliva) in relation to different lifestyle factors and environmental conditions and to…
- Conditions
- Vaginal Microbiome, Skin Microbiome, Saliva Microbiome
- Trial name
- Isala (NCT04319536)
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Barrett Esophagus
Longitudinal Oral Microbiome Sampling for BE
This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE).
- Trial name
- NCT05133102
- Testing
- Sample collection
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed
Microbiome and Immunogenity of Saliva During Orthodontic Therapy
There are two essential ways of treatment in the field of orthodontics. The fixed appliance treatment with self-ligating or conventional brackets and treatment with aligners.
- Conditions
- Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed, Oral Microbiome, Cell Culture
- Trial name
- NCT04139538
- Testing
- orthodontic treatment
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Human Microbiome
Xylitol and Sorbitol Effects on the Oral Microbiome
Chewing gum containing xylitol may help prevent caries by reducing levels of mutans streptococci (MS) and lactobacilli in saliva and plaque. Very little is known about other species which are possibly beneficial to oral health.
- Trial name
- NCT03668015
- Testing
- Xylitol then Sorbitol gum, Sorbitol then Xylitol gum
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Helicobacter Pylori Infection
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H.
- Trial name
- NCT03730766
- Testing
- Esomeprazole, Amoxicillin, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy Volunteers
Sample Collection From Healthy Volunteers for Assay Optimization
Background: The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. They study how parts of living things come together to make a whole.
- Trial name
- NCT03538600
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Menopause
Menopause and Oral Microbiome
The study examines the saliva and dental plaque microbiome of women aged 35-65 in two groups: postmenopausal (case) and premenopausal (control). For this purpose, Illumina Platform to sequence 16S rRNA gene regions will be used.
- Trial name
- NCT05335733
- Testing
- Intraoral examination, saliva, dental plaque and serum collection.
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Ege University
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University