Clinical trials: Salivary Dysfunction
Sjogren Syndrome
Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR).
- Trial name
- SPEEDCARS (NCT02132585)
- Testing
- Speckle tracking echocardiography
- Where
- 2 sites in Italy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction
Phase I trial to study the effectiveness of erlotinib in treating patients who have metastatic or unresectable solid tumors and liver or kidney dysfunction.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT00030498
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma
Longitudinal Oral Health Changes After Head and Neck Radiotherapy
This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple…
- Conditions
- Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma, Periodontal Disease, Xerostomia
- Trial name
- HN-ORAL-RT (NCT07394842)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Dry Eye, Sjogren's Syndrome
Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye
The study aims to test the safety of Repetitive Magnetic Stimulation (RMS) treatment for dry eye disease. Patients are asked to undergo a one-time treatment with Epitech Ocular Magnetic Stimulation Device on one eye in the first…
- Conditions
- Dry Eye, Sjogren's Syndrome, Aqueous Tear Deficiency, Meibomian Gland Dysfunction
- Trial name
- NCT03012698
- Testing
- Ocular Repetitive Magnetic Stimulation (RMS) treatment
- Where
- 3 sites in Israel
- Volunteers
- 29 people
- Sponsor
- Epitech Mag Ltd.
Xerostomia, Autoimmune Diseases
Study of Oral Bacteria in Patients With Dry Mouth
This study will examine the types of bacteria present in the dental plaque of patients with persistent dry mouth. Saliva is essential for digestion and swallowing and for maintaining the normal mineralization of teeth.
- Trial name
- NCT00048685
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Sjögren, Sjögren Syndrome
Pelvic Floor Exercises in Patients With Sjögren's
When the literature is examined, the positive effects of pelvic floor exercises on sexual functions have been supported by studies.
- Trial name
- NCT05079581
- Testing
- Pelvic floor exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Akdeniz University
Sjögren's Syndrome, Meibomian Gland Dysfunction
Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ?
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03060005
- Testing
- Tears Naturale Forte, liposic
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tung Wah Hospital
Sjogren Syndrome
Temporomandibular Joint Dysfunction in Sjögren's Syndrome
Study Purpose The purpose of this observational study is to determine the prevalence of temporomandibular dysfunction (TMD) in individuals diagnosed with Sjögren's syndrome and to examine the relationship between disease activity…
- Trial name
- Sjögren (NCT07248306)
- Testing
- Temporomandibular Joint Function
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Pamukkale University
Alzheimer's Disease, Mild Cognitive Impairment
Use of Saliva for Alzheimer's Disease Diagnosis
Although saliva is not generally regarded as one of the most interesting biological fluids, the fact that it can be sampled using simple, noninvasive methods makes it an interesting alternative to cerebrospinal fluid (CSF) or…
- Trial name
- SalivALZ (NCT02864303)
- Testing
- Saliva samples
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
Lymphoma, Salivary Gland Disease
Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome
This study will follow patients with salivary gland dysfunction to identify the long-term course of this disorder and its effects on the mouth, oral function, and overall health.
- Conditions
- Lymphoma, Salivary Gland Disease, Sjogren's Syndrome, Xerostomia
- Trial name
- NCT00001852
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Smell Dysfunction, Taste Dysfunction
Post-Covid-19 Patients Follow-up Study
Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients
- Conditions
- Smell Dysfunction, Taste Dysfunction, Trigeminal Dysfunction, Salivary Dysfunction
- Trial name
- COVID-19 (NCT07571382)
- Testing
- Smell training
- Where
- Norway
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Dementia
Effects of Snoezelen Multisensory Therapy on Older Adults With Dementia
This randomized, controlled, longitudinal clinical trial investigates the effects of Snoezelen Multisensory Therapy (SMT) as an adjunct to standard therapy (ST) in older adults with dementia.
- Trial name
- SMT (NCT07657208)
- Testing
- Snoezelen Multisensory Therapy, Standard Therapy
- Where
- Slovenia
- Volunteers
- 63 people
- Sponsor
- University of Primorska
Sjogren's Syndrome, Salivary Gland
Evaluation of Salivary Gland Dysfunction
This study will evaluate patients with complaints of dry mouth to determine the cause and severity of their salivary gland dysfunction and their possible eligibility for other NIDCR protocols.
- Trial name
- NCT00001196
- Where
- United States
- Volunteers
- 1,740 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Graft vs Host Disease, Sjogren's Syndrome
Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells
This study will examine whether transplanted stem cells can turn into salivary gland cells in stem cell recipients. If so, stem cells might be used to restore salivary gland function in patients with Sjogren's syndrome and other…
- Trial name
- NCT00023491
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Primary Sjögren Syndrome, Vaginitis Candida
Sjögren and Gynecologic Considerations
Sjögren's syndrome is an autoimmune disorder characterized by glandular and extra-glandular manifestations. It is called primary Sjögren's syndrome (pSS) in absence of another connective tissue disease.
- Conditions
- Primary Sjögren Syndrome, Vaginitis Candida, Vaginitis, Sexual Dysfunction
- Trial name
- NCT05670535
- Testing
- Visual analogue scale (VAS) for dyspareunia, Visual analogue scale (VAS) for vaginal dryness, The European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Healthy Volunteer, Sjogren's Syndrome
Characterization of Diseases With Salivary Gland Involvement
Background: Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life.
- Conditions
- Healthy Volunteer, Sjogren's Syndrome, Salivary Gland Disease
- Trial name
- NCT02327884
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Meibomian Gland Dysfunction, Sjögren's Syndrome
Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03434106
- Testing
- liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LanZhou University
Sjogren's Syndrome, Oral Health
Oral Health Needs Assessment of Sjogren s Syndrome and Salivary Gland Dysfunction Cohorts and Healthy Volunteers Evaluating Oral Health Disparities as Determinants of Oral Health in a High-Risk Population
Background: A person s dental health depends on many factors. Some are social, economic, or behavioral. Some are environmental. People with Sj(SqrRoot)(Delta)gren s Syndrome have a change in the amount and quality of saliva.
- Trial name
- NCT03327870
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Acute Hepatitis
ADRENAL FUNCTION IN PATIENTS WITH ACUTE HEPATITIS
A high frequency of adrenal dysfunction (AD) has been reported in severe acute hepatitis (SAH) using the dosage of serum total cortisol (STC).
- Trial name
- CORT-HEPAT (NCT02859584)
- Testing
- Measure OF SERUM TOTAL CORTISOL, SERUM FREE AND SALIVARY CORTISOL
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University