Clinical trials: Saphenous Vein
Varicose Veins
Endoveneous Histologic Study
A new technique, mechanochemical endovenous ablation (MOCA), using the ClariVein ® system is recently developed. To date, histopathological data after mechanochemical endovenous ablation are not known.
- Trial name
- NCT03326219
- Testing
- Clarivein
- Where
- Netherlands
- Sponsor
- Rijnstate Hospital
Varicose Veins, Dilated Veins
Primary Insufficiency of the GSV With a Diameter >/= 12 mm, Antero-lateral Branches, or Below the Knee
The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches and insufficiency of the…
- Trial name
- MOCA-XL (NCT02345018)
- Testing
- Mechano-chemical ablation
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Rijnstate Hospital
Coronary Artery Stenoses
Five-year Patency of No-touch Saphenous Vein Grafts in On-pump Versus Clamp-less Off-pump Coronary Artery Bypass Surgery
Randomised controlled trials (RCTs) have shown high long-term patency for no-touch saphenous vein grafts (NTSVGs), comparable to the internal thoracic artery in on-pump coronary artery bypass grafting (CABG).
- Trial name
- NCT03447197
- Testing
- The use of extracorporeal circulation
- Volunteers
- 59 people
- Sponsor
- Örebro County Council
Varicose Veins of Lower Limb, Great Saphenous Vein (GSV) With Venous Reflux Disease
Endovenous Laser Ablation With 1940 nm Versus 1470 nm
1. Study Design: A single-blind, prospective, randomized controlled trial (RCT) conducted at Kafrelsheikh University Hospital to compare the efficacy and safety of 1940 nm vs. 1470 nm diode lasers for EVLA. 2.
- Trial name
- EVLA (NCT07603570)
- Testing
- EVLA for SFJ with laser 1470, EVLA for SFJ with laser 1940
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Kafrelsheikh University
Varicose Veins of Leg With Long Saphenous Vein Distribution, Varicose Veins of Lower Limb
Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein
This study compares two minimally invasive treatments for varicose veins in the legs, specifically the great saphenous vein. Varicose veins can cause symptoms such as leg pain, swelling, and skin changes.
- Trial name
- NCT07561320
- Testing
- Flebogrif, Polidocanol foam sclerotherapy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Antonio Eduardo Zerati
Saphenous Vein Graft Atherosclerosis
The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial
This is a phase IV, multi-center, double-blind, randomized, placebo- controlled study evaluating the effect of alirocumab on SVG atherosclerotic disease burden, as assessed by IVUS at baseline and following 78 weeks of treatment…
- Trial name
- ASAP-SVG (NCT03542110)
- Testing
- Alirocumab 150 MG/ML subcutaneous injection
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease
Study to Test the Efficacy and Safety of Drug Eluting vs. Bare-Metal Stents for Saphenous Vein Graft Interventions
Prospective multicenter controlled randomized trial to compare the safety and efficacy of drug eluting vs. bare metal stents in percutaneous coronary interventions of saphenous vein grafts.
- Trial name
- BASKET-SAVAGE (NCT00595647)
- Testing
- Drug eluting stent, Bare metal stent
- Where
- 5 sites in Denmark, Germany and 1 more
- Volunteers
- 162 people
- Sponsor
- University Hospital, Basel, Switzerland
Angina Pectoris
Vein vs Arterial Grafts for Coronary Artery Bypass Grafting Surgery
The investigators have developed a novel technique for saphenous vein graft harvesting for coronary artery bypass grafting (CABG) where the graft is harvested with a pedicle of surrounding tissue.
- Trial name
- NCT02158455
- Testing
- NT SVG grafts
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Region Örebro County
LAD (Left Anterior Descending) Coronary Artery Stenosis
Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique
The objective of this study is to compare different surgical strategies for management of severely diseased LAD artery during CABG i.e. LIMA on-lay patch vs.
- Trial name
- NCT06835114
- Testing
- CABG, LIMA on lay patch, Safenous vein patch
- Volunteers
- 90 people
- Sponsor
- Assiut University
Varicose Veins
Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis
The purpose of this study is to compare two therapeutic procedures in the treatment of isolated varicosis of the anterior accessory great saphenous vein (AAGSV): crossectomy and avulsion of the varicose AAGSV versus foam…
- Trial name
- NCT02010723
- Testing
- surgery, sclerotherapy with aethoxysclerol foam
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Occlusions Vein, Chronic Venous Insufficiency
Cyanoacrylate Closure Versus Surgical Stripping for Incompetent Saphenous Veins
The purpose of this study is to evaluate the non-inferior, clinical outcomes after cyanoacrylate closure comparing the surgical stripping for incompetent saphenous veins.
- Trial name
- CASS (NCT03835559)
- Testing
- Cyanoacrylate closure, Surgical stripping
- Where
- 2 sites in South Korea
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Varicose Veins of Lower Limb
Long Term Study of 3 Radiofrequency Devices
To establish which of the radiofrequency venous ablation modalities studied in the original 3RF study (Venefit (Closurefast), vs. Radiofrequency induced Thermal Therapy vs.
- Trial name
- 3RF-5Years (NCT04720027)
- Testing
- Duplex imaging
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Worcestershire Acute Hospitals NHS Trust
Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting.
This randomized, double-blind clinical trial aims to evaluate the impact of photobiomodulation therapy on postoperative outcomes in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Graft (CABG), Surgical Wound Healing
- Trial name
- PHOTON (NCT07699679)
- Testing
- Photobiomodulation Therapy, Conventional Saphenous Vein Harvesting, No-Touch Saphenous Vein Harvesting
- Where
- Brazil
- Volunteers
- 292 people
- Sponsor
- Federal University of São Paulo
Leg Wound Complication After No-Touch Harvestingof Veins
Proximal Versus Distal Segments of No-Touch Saphenous Vein Grafts
The optimum segment of No-Touch veins for bypassing is still undefined. The purpose of this study is to assess the incidence of leg wound complication after No-Touch harvesting of proximal segment of saphenous veins compared to…
- Trial name
- NCT04284956
- Testing
- Proximal and distal segment of saphenous vein harvested by No-Touch technique
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Bypass Surgery
CD0104 VEST II Post Marketing Surveillance Study
This study is designed to collect post market data on use of the VEST, particularly on saphenous vein grafts to the right territory of the heart.
- Trial name
- VEST II (NCT02332330)
- Testing
- VEST
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Vascular Graft Solutions Ltd.
Triple Vessel Disease, Unstable Angina
Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting
In coronary artery bypass grafting, saphenous veins are widely used as a composite grafts that are Y-anastomosed to in-situ left internal thoracic artery.
- Conditions
- Triple Vessel Disease, Unstable Angina, Stable Angina, Myocardial Infarction
- Trial name
- COSAVEGUL-1 (NCT01974492)
- Testing
- Upper leg vein harvesting, Lower leg vein harvesting
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
The Effect Of Antiplatelets Therapy On Saphenous Vein Coronary Artery Bypass Graft Patency
This protocol is designed to evaluate the effect of antiplatelets (Tirafiban and Prasugrel) on the incidence of early and intermediate graft patency after CABG.
- Trial name
- NCT01598337
- Testing
- Aspirin, Tirofiban, Clopidogrel
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Prince Sultan Cardiac Center, Adult Cardiology Department.
Chronic Venous Insufficiency
Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein
The aim of this study is to perform a randomized, prospective trial comparing the two current methods of treatment for chronic venous insufficiency, in an effort to evaluate complications and outcomes for each method, and…
- Trial name
- NCT02236338
- Testing
- Ablation of the Incompetent Greater Saphenous Vein, ClosureFAST radiofrequency catheter, EVLT 980nm diode laser system
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Virginia Commonwealth University
Varicose Veins
Treatment of Saphenous Vein Reflux With 1920-nm Diode Laser
Objective: Compare venous occlusion rates at a one-year follow-up comparing 1920-nm versus 1470-nm laser treatment. Design: Non-randomized prospective study.
- Trial name
- NCT02504684
- Testing
- Endovenous 1920-nm diode laser, Endovenous 1470-nm diode laser
- Where
- Brazil
- Volunteers
- 67 people
- Sponsor
- Instituto Vascular BH
End Stage Renal Failure on Dialysis, Hemodialysis Access Failure
Results of Cold Stored Allografts in Vascular Access
Vascular access creation in patients with renal failure requiring long-term hemodialysis can be a challenge when there is no more autologous material or in case of infection, in a population undergoing long term dialysis with a…
- Trial name
- RAVASC (NCT04446546)
- Testing
- Vascular access by pass using a cold stored venous allograft
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France