Clinical trials: Sarcoidosis Lung
Pulmonary Sarcoidosis
Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis
This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment.
- Trial name
- NCT05415137
- Testing
- Efzofitimod 3 mg/kg, Efzofitimod 5 mg/kg
- Where
- 91 sites in United States, Brazil and 7 more
- Volunteers
- 268 people
- Sponsor
- aTyr Pharma, Inc.
Sarcoidosis, Pulmonary
Pirfenidone for Progressive Fibrotic Sarcoidosis
Study comparing pirfenidone versus placebo for patients with advanced fibrotic sarcoidosis
- Trial name
- PirFS (NCT03260556)
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Pulmonary Sarcoidosis
Antibody Response to Influenza Vaccine in Patients With Sarcoidosis
The purpose of this study is to determine the efficacy of influenza vaccine (antibody response) in patients with sarcoidosis.
- Trial name
- IVS (NCT00828828)
- Testing
- Influenza Vaccine
- Where
- Iran
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Sarcoidosis
Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis
For pulmonary sarcoidosis, the initial dose recommended by the joint statement of the American Thoracic Society (ATS), European Respiratory Society (ERS), and The World Association of Sarcoidosis and Other Granulomatous Disorders…
- Trial name
- SARCORT (NCT03265405)
- Testing
- Low dose prednisolone, Medium dose prednisolone
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Cancer, Sarcoidosis
Comparison of Three Different Puncture Techniques in EBUS-TBNA
The purpose of this study was to compare the accuracy and sensitivity of slow-pull capillary technique, traditional suction aspiration and non negative pressure puncture in the diagnosis of mediastinal and/or hilar lymph node…
- Conditions
- Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT05628454
- Testing
- Endobronchial ultrasound-guided transbronchial needle Slow-pull capillary sampling, Endobronchial ultrasound-guided transbronchial needle aspiration, Endobronchial ultrasound-guided transbronchial needle capillary sampling
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Friendship Hospital
Pulmonary Sarcoidosis
Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis
This randomized, double-blind, placebo matched to efzofitimod-controlled, study will evaluate the safety, tolerability, immunogenicity, pharmacokinetic (PK), and preliminary efficacy of multiple ascending doses of IV efzofitimod…
- Trial name
- NCT03824392
- Where
- 15 sites in United States
- Volunteers
- 37 people
- Sponsor
- aTyr Pharma, Inc.
Pulmonary Sarcoidosis
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients with Pulmonary Sarcoidosis with or Without Extrapulmonary Manifestations
- Trial name
- NCT05890729
- Where
- 33 sites in United States, Czechia and 4 more
- Volunteers
- 32 people
- Sponsor
- Xentria, Inc.
Endobronchial Mucosal Pathology in Pulmonary Sarcoidosis
Endobronchial Mucosal Biopsy in Patients With Suspected Pulmonary Sarcoidosis
This prospective interventional study was done between May and September 2020. We included 20 patients from the chest department, Alexandria Main University Hospital (AMUH) with the inclusion criteria of having suspected…
- Trial name
- NCT04904939
- Testing
- Bronchoscopic mucosal biopsy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary
Diagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy
The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis.
- Conditions
- Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary, Mediastinal Diseases
- Trial name
- NCT05374447
- Testing
- Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- George Washington University
Isolated Mediastinal Lymphadenopathy, Sarcoidosis
A Clinical tRial of Endobronchial Ultrasound for the Diagnosis of MEDiastinal lymphadenopathY (REMEDY)
Enlarged glands in the chest (mediastinal lymphadenopathy) is a common problem and may have a variety of different causes. In the past an operation (mediastinoscopy) was required to diagnose the glands.
- Conditions
- Isolated Mediastinal Lymphadenopathy, Sarcoidosis, Tuberculosis, Lung Cancer
- Trial name
- REMEDY (NCT00932854)
- Testing
- EBUS
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University College London Hospitals
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT
This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with pulmonary hypertension to determine the recommended dose range, evaluate the change from baseline in 6-minute walk distance…
- Conditions
- Pulmonary Arterial Hypertension, Pulmonary Hypertension, Interstitial Lung Disease, Idiopathic Interstitial Pneumonia
- Trial name
- NCT02036970
- Testing
- Bardoxolone methyl
- Where
- 32 sites in United States, Germany
- Volunteers
- 166 people
- Sponsor
- Biogen
Sarcoidosis, Pulmonary
A Study to Assess the Efficacy and Safety of Namilumab in Participants With Chronic Pulmonary Sarcoidosis
This is a randomized, double-blind, placebo-controlled study with an open-label extension (OLE).
- Trial name
- RESOLVE-Lung (NCT05314517)
- Testing
- Namilumab
- Where
- 47 sites in United States, Belgium and 5 more
- Volunteers
- 107 people
- Sponsor
- Kinevant Sciences GmbH
Pulmonary Sarcoidosis
Study of Nicotine Patches in Patients With Sarcoidosis
The purpose of this study is to compare peoples with disease (sarcoidosis) to those without disease. We want to see if people with sarcoidosis have a different immune response to those people without disease.
- Trial name
- NCT00701207
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Elliott Crouser MD
Sarcoidosis, Pulmonary
Endobronchial Ultrasound Strain Elastography in Sarcoidosis
Strain elastography (SE) is an imaging method used for the measurement of relative tissue elasticity through qualitative (color pattern) or semi-quantitative methods (strain ratio or strain histogram).
- Trial name
- NCT04895111
- Testing
- Endobronchial ultrasound strain elastography
- Where
- Italy
- Volunteers
- 701 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-Small Cell Lung Cancer, Adenocarcinoma
A Phase I Trial of SS1 (dsFv) PE38 With Paclitaxel, Carboplatin, and Bevacizumab in Subjects With Unresectable Non-Small Cell Lung Adenocarcinoma
Background: Advanced cases of non-small-cell lung carcinoma (NSCLC) usually are not successfully treated with standard therapies. Even treatments that attempt to specifically target NSCLC cells have not proved effective.
- Trial name
- NCT01051934
- Testing
- SS1 (dsFv) PE38, Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoidosis, Pulmonary
Evaluation of the Efficacy and Safety of Compound Betamethasone in Pulmonary Sarcoidosis
The goal of this clinical trial is to learn whether a study drug called Compound Betamethasone (also known as Diprospan) works to treat pulmonary sarcoidosis in people with early-stage disease (stage I or II).
- Trial name
- NCT07668895
- Testing
- Prednisone, Compound betamethasone
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking Union Medical College Hospital
Obesity, Interstitial Lung Disease
Feasibility of Semaglutide in Advanced Lung Disease
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1.
- Conditions
- Obesity, Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Pulmonary
- Trial name
- NCT05746039
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Sarcoidosis, Sarcoidosis, Pulmonary
The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
This project focuses on the sub-group population with pulmonary sarcoidosis - a condition that causes red swollen tissue called granulomas to develop in organs such as the lungs.
- Conditions
- Sarcoidosis, Sarcoidosis, Pulmonary, ILD, Interstitial Lung Disease
- Trial name
- NCT03336736
- Testing
- Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kingston University
Sarcoidosis, COVID-19
Number of Participants Diagnosed With Sarcoidosis by Bronchoscopic Transbronchial Needle Aspiration After COVID- 2019 .
The goal of this observational study is to learn about sarcoidosis development after COVID-19 infection. The main question it aims to answer is: prevalence of Sarcoidosis among patients previously infected with COVID-19.
- Trial name
- NCT06043882
- Testing
- flexible bronchoscopy
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Ain Shams University
Sarcoidosis
Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
The purpose of this study is to determine if nicotine treatment is beneficial for the treatment of sarcoidosis. Sarcoidosis is a disease of unknown cause that leads to inflammation. This disease affects your body's organs.
- Trial name
- NCT02265874
- Testing
- Habitrol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University