Clinical trials: Sarcomas
Recurrent Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma
A Phase II Study of Tivozanib in Patients With Metastatic and Non-resectable Soft Tissue Sarcomas
This study is for patients who have been diagnosed with soft tissue sarcoma that has spread (metastasized) or that is not eligible for removal by surgery.
- Conditions
- Recurrent Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma, Stage IV Adult Soft Tissue Sarcoma
- Trial name
- NCT01782313
- Testing
- tivozanib, laboratory biomarker analysis
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- Northwestern University
Angiosarcoma
Propranolol in Angiosarcoma
This is a window opportunity study of propranolol in patients with angiosarcoma. The aim of this study is to prospectively evaluate the activity of propranolol in the clinical setting as monotherapy, where the neoadjuvant setting…
- Trial name
- NCT04518124
- Testing
- Propranolol
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- The Netherlands Cancer Institute
Metastatic Soft Tissue Sarcoma
Phase II Study of Regorafenib as Maintenance Therapy
Multicenter double-blind placebo-controlled randomized Phase II study comparing regorafenib® to placebo, as maintenance therapy in metastatic soft-tissue non-adipocytic sarcomas experiencing stable disease or response after 6…
- Trial name
- EREMISS (NCT03793361)
- Testing
- Regorafenib
- Where
- 20 sites in France
- Volunteers
- 127 people
- Sponsor
- Centre Oscar Lambret
Bladder Cancer, Prostate Cancer
Associations Between Chemotherapy-Induced Nausea in Patients With Genitourinary, Sarcoma or Melanoma Cancers and Changes in Gut Microbiome: Potential for Precision Therapeutics
The objective of this pilot cohort study is to investigate associations between CIN and changes in gut microbiome composition profiles.
- Conditions
- Bladder Cancer, Prostate Cancer, Testicular Cancer, Bladder Carcinoma
- Trial name
- NCT05819827
- Testing
- Blood and Tissue
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Soft Tissue Sarcoma
5-Day Preoperative Radiation for Soft Tissue Sarcoma
The purpose of this study is to examine the safety and efficacy of an abbreviated course of preoperative radiation, given over five days, for patients with soft tissue sarcoma of the extremity, trunk or retroperitoneum.
- Trial name
- NCT06087861
- Testing
- External Beam Radiotherapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Stanford University
Advanced Soft Tissue Sarcoma
Geno-radiomics Based Model for Evaluation of Immunotherapy and Targeted Therapy for Advanced Soft Tissue Sarcoma
In this study, a new post-processing image technology - radiomics is used to screen out parameters of CT and MRI images, which could effectively evaluate the efficacy and prognosis of immunotherapy plus targeted therapy for soft…
- Trial name
- NCT06062927
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Liposarcoma, Myxoid, Liposarcoma, Dedifferentiated
Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone.
This is a phase 2 study conducted in two sequential stages: The first stage is an Italian single institution, single arm, pilot study, aimed at exploring the activity of the combination T and P in myxoid liposarcoma patients who…
- Conditions
- Liposarcoma, Myxoid, Liposarcoma, Dedifferentiated, Liposarcoma, Round Cell
- Trial name
- TRABEPIO (NCT04794127)
- Testing
- Trabectedin, Pioglitazone Oral Product
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Osteosarcoma, Resection Margins
B7-H3 NIR Imaging for Osteosarcoma Surgery
Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and…
- Conditions
- Osteosarcoma, Resection Margins, B7-H3 Probe, Local Recurrence
- Trial name
- ROLN-B7-H3 (NCT06778603)
- Testing
- a targeted probe B7H3-IRDye800CW
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University People's Hospital
Soft Tissue Sarcoma
Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)
To compare the efficacy and safety in subjects with advanced or metastatic LMS previously treated with an anthracycline.
- Trial name
- NCT05712694
- Testing
- ADI PEG20
- Where
- 30 sites in United States, Canada and 1 more
- Volunteers
- 218 people
- Sponsor
- Polaris Group
Bone Sarcomas, Financial Toxicity
Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas
To learn about the financial stress patients undergoing surgery to treat orthopedic cancer experience because of the costs of cancer care, and to learn about the effects of financial stress on participants quality of life.
- Trial name
- NCT07215611
- Testing
- data collection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Soft Tissue Sarcoma
Dose Finding Study of L19TNF and Doxorubicin in Patients With STS
The study is aimed at evaluating the safety of L19TNF in combination with the most appropriate dose of doxorubicin.
- Trial name
- DOXO75 (NCT04032964)
- Testing
- L19TNF, DOXORUBICIN
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Philogen S.p.A.
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors
This phase I trial studies the safety of transplantation with a haploidentical donor peripheral blood stem cell graft depleted of TCRαβ+ cells and CD19+ cells in conjunction with the immunomodulating drug, Zoledronate, given in…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma
- Trial name
- NCT02508038
- Testing
- TCRαβ+/CD19+ depleted Haploidentical HSCT, Zoledronate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Wisconsin, Madison
Cancer
A Phase II Study of Anlotinib in STS Patients
Anlotibib (ALTN) is a kind of innovative medicines approved by State Food and Drug Administration（SFDA） which was researched by Jiangsu Chia-tai Tianqing Pharmaceutical Co., Ltd.
- Trial name
- ALTN/STS (NCT01878448)
- Testing
- Anlotinib
- Where
- 16 sites in China
- Volunteers
- 166 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Diffuse Large B-cell-lymphoma
Venetoclax Plus R-ICE Chemotherapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
The purpose of this study is to determine the correct dose and safety of adding a new cancer drug, venetoclax, to a standard combination of chemotherapy drugs as a second treatment for relapsed/refractory DLBCL.
- Trial name
- NCT03064867
- Testing
- Venetoclax, Rituximab, Ifosfamide
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Molly Gallogly
Uterine Sarcoma
Molecular Mechanism Study of Uterine Sarcoma
The purpose of this project was to use multi-omics technology to screen the key factors for the occurrence and development of uterine sarcoma.
- Trial name
- NCT05881967
- Testing
- Diagnostic biomarker
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shixuan Wang
Liposarcoma
Efatutazone Dihydrochloride in Treating Patients With Previously Treated Myxoid Liposarcoma That Cannot Be Removed by Surgery
This phase II trial studies how well efatutazone dihydrochloride works in treating patients with previously treated myxoid liposarcoma that cannot be removed by surgery.
- Trial name
- NCT02249949
- Testing
- efatutazone
- Where
- 127 sites in United States
- Volunteers
- 15 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Liposarcoma, Dedifferentiated
Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dedifferentiated Liposarcoma
This study is open to people with a type of cancer called dedifferentiated liposarcoma. People with advanced liposarcoma aged 18 or older who are not receiving any other cancer treatment can participate.
- Trial name
- NCT05218499
- Testing
- Brigimadlin, Doxorubicin
- Where
- 109 sites in United States, Australia and 20 more
- Volunteers
- 400 people
- Sponsor
- Boehringer Ingelheim
Rhabdomyosarcoma
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
FaR-RMS is an over-arching study for children and adults with newly diagnosed and relapsed rhabdomyosarcoma (RMS)
- Trial name
- FaR-RMS (NCT04625907)
- Testing
- Irinotecan, Actinomycin D, Doxorubicin
- Where
- 128 sites in Australia, Austria and 18 more
- Volunteers
- 1,672 people
- Sponsor
- University of Birmingham
Low Grade Endometrial Stromal Sarcoma
Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS)
The primary objective is to compare the progression-free survival (PFS) between aromatase inhibitors interruption and aromatase inhibitors maintenance strategies in patients with a locally advanced or metastatic Low Grade…
- Trial name
- BFR-ESS (NCT03624244)
- Testing
- Aromatase Inhibitors
- Where
- 22 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Leon Berard
Ewing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion
Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial
This clinical trial evaluates the effect of radiotherapy doses based on tumor size and tumor-specific characteristics (biologically-adapted) in treating patients with Ewing sarcoma.
- Trial name
- BEAR (NCT07188532)
- Testing
- Biospecimen Collection, Chemotherapy, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Mayo Clinic