Clinical trials: Sarcopenia in Liver Cirrhosis
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis
MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study
The goal of this observational study is to understand how metabolic dysfunction-associated steatotic liver disease (MASLD) changes over time in individuals with type 2 diabetes who previously participated in the EPSONIP study.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis, Advanced Fibrosis, Sarcopenia
- Trial name
- EPSOMIP2 (NCT07312136)
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Linkoeping University
Liver Cirrhoses, Hepatocellular Carcinoma (HCC)
A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
DETECT-HCC-ESLD is a prospective multicenter study designed to examine early detection and risk stratification of hepatocellular carcinoma (HCC) in individuals with advanced liver disease.
- Conditions
- Liver Cirrhoses, Hepatocellular Carcinoma (HCC), Sarcopenia in Liver Cirrhosis, Portal Hypertension Related to Cirrhosis
- Trial name
- DETECT-HCC (NCT07291141)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Mattias Ekstedt
Chronic Liver Disease and Cirrhosis
Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial
The goal of this clinical trial is to evaluate whether home-based exercise interventions, including aerobic exercise (AE) and a combination of aerobic and resistance exercise (ARE), can improve physical and health-related…
- Trial name
- NCT06892366
- Testing
- Home-Based Aerobic Exercise Program, Home-Based Aerobic and Resistance Exercise (ARE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University
Cirrhosis, Liver, Hepatic Encephalopathy
Role of Sarcopenia and Nutritional/Physical Therapy Intervention in Post-TIPS Hepatic Encephalopathy
The placement of TIPS (transjugular intrahepatic portosystemic shunt) is the most effective strategy to treat complications of portal hypertension.
- Conditions
- Cirrhosis, Liver, Hepatic Encephalopathy, Sarcopenia
- Trial name
- NCT05346029
- Testing
- Lifestyle intervention
- Where
- 3 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Anna Baiges
Sarcopenia
Austrian Biobanking Study for Sarcopenia
The investigators aim to set up a biobanking study in Graz, Austria, to study sarcopenia in liver cirrhosis and chronic inflammatory bowel disease by collecting a standardized dataset including routine clinical and biochemical…
- Trial name
- ASGSC (NCT06632743)
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Graz
Cirrhosis, Myosteatosis
Protocol for Muscle Attenuation Cut-offs in Cirrhosis
The goal of this observational study is to learn if new muscle attenuation cut-offs for the definition of myosteatosis can better predict survival in patients with cirrhosis.
- Conditions
- Cirrhosis, Myosteatosis, Sarcopenia, Sarcopenia in Liver Cirrhosis
- Trial name
- Myocirrhosis (NCT06593015)
- Testing
- Radiological tool for the diagnosis of myosteatosis
- Where
- Italy
- Volunteers
- 1,296 people
- Sponsor
- University of Roma La Sapienza
Hepatic Encephalopathy
Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy
This is a global study to compare the effects of AXA1665, an orally active mixture of amino acids, compared to placebo, on cognitive and physical function, as well as the safety and tolerability of AXA1665.
- Trial name
- EMMPOWER (NCT04816916)
- Testing
- AXA1665
- Where
- 40 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Axcella Health, Inc
Malnutrition, Cirrhosis, Liver
Comparison of Nutritional Screening Tools in Liver Cirrhosis Patients
This study compares two nutritional screening questionnaires in cirrhotic patients. All patients will be assessed with both questionnaires, besides a complete nutritional assessment.
- Trial name
- NCT04502719
- Testing
- Nutritional screening.
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Clinic of Barcelona
Hepatic Encephalopathy
Microbiota, Sarcopenia, and Hepatic Encephalopathy Change in Cirrhotic Patients Before and After Rehabilitation
Through this plan, it will provide many benefits to patients with liver cirrhosis complicated with sarcopenia and/or hepatic encephalopathy, their family members, and the government in Taiwan: 1.
- Trial name
- NCT06040814
- Testing
- Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Liver Cirrhosis, Fibrosis
Growth Hormone in Decompensated Liver Cirrhosis
Globally, cirrhosis and liver cancer carries a huge burden and accounts for about 3.5% (2 million) of all deaths every year. Once decompensated, i.e.
- Conditions
- Liver Cirrhosis, Fibrosis, End Stage Liver Disease, Digestive System Disease
- Trial name
- NCT05253287
- Testing
- Growth Hormone
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
End-Stage Liver Disease, Liver Transplantation
Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates
This study will evaluate frailty, nutrition, sarcopenia, and psychological health in people waiting for a liver transplant. The purpose is to understand how these factors affect outcomes before and after transplantation.
- Conditions
- End-Stage Liver Disease, Liver Transplantation, Cirrhosis
- Trial name
- NCT07414095
- Testing
- Comprehensive Observational Assessment in Liver Transplant Candidates
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Cirrhosis
A Cross Sectional Study for Determining Prevalence of Sarcopenia and Myosteatosis in Cirrhotic Patients and to Study the Association Between Imaging and Clinical Parameters
Cirrhosis is associated with a wide variety of metabolic changes in the body. Ascites, hepatic encephalopathy, variceal bleeding, renal dysfunction, and hepatocellular carcinoma are the most widely recognised complications in…
- Trial name
- Myo (NCT05157308)
- Where
- India
- Volunteers
- 385 people
- Sponsor
- Asian Institute of Gastroenterology, India
Cirrhosis, Sarcopenia
Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia
The study evaluates whether sarcopenia influences the prevalence of abdominal hernias in patients with cirrhosis.
- Conditions
- Cirrhosis, Sarcopenia, Malnutrition, Hernia, Abdominal
- Trial name
- NCT03458845
- Testing
- Computed Tomography Scan
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
Liver Cirrhosis
Efficacy and Safety of Testosterone Therapy in Improving Sarcopenia in Men With Cirrhosis.
Study Population- Patient with cirrhosis with any aetiology with sarcopenia visiting ILBS OPD/IPDs who are willing to visit ILBS gymnasium twice weekly for first month.
- Trial name
- NCT03995251
- Testing
- Testosterone Supplementation, Standard Medical Treatment, Exercise
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
The Impact of a Dietary Fiber Enriched Diet on the Outcome of Patients with Liver Cirrhosis
The goal of this dietary intervention is to study the impact of a dietary fiber enriched diet on the intestinal dysbiosis, systemic inflammation and cirrhosis-related complications in patients with liver cirrhosis.
- Trial name
- ChainCirr (NCT06634186)
- Testing
- Dietary intervention
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Hannover Medical School
Sarcopenia, Liver Cirrhosis
ELECTRICAL STIMULATION AND EXERCISE FOR MUSCLE LOSS IN CIRRHOSIS PATIENTS
Introduction: Sarcopenia, whether primary or secondary, substantially impacts the quality of life of patients post-hospital discharge. Compromised functional capacity can lead to a high prevalence of readmissions.
- Trial name
- E-SEEM (NCT07162636)
- Testing
- NMES+, NMES -
- Volunteers
- 112 people
- Sponsor
- Hospital Universitário Professor Edgard Santos
Cirrhosis, Liver, Sarcopenia
Body Composition Changes After TIPS and Associated Clinical Outcomes
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients…
- Trial name
- NCT05420753
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Liver Diseases, Cirrhosis, Liver
Evaluation of a High Protein Plant Dominant Diet (HiProPlaDo) in Liver Cirrhosis
The aim of the study is to compare the implementation of a high-protein diet based on plant-based foods (Group A) with the usual guidelines for liver patients, in which protein needs are met by low-fat animal foods (Group B).
- Conditions
- Liver Diseases, Cirrhosis, Liver, Sarcopenia, Malnutrition; Cachexia
- Trial name
- HiProPlado (NCT07028580)
- Testing
- Diet based on animal proteins, Diet based on plant proteins., General instructions for patients with liver disease.
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Agricultural University of Athens
Sarcopenia in Liver Cirrhosis
Assessment of Sarcopenia in Patients With Liver Cirrhosis and Its Prognostic Value in Liver Transplant Candidates
Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, shown to be prevalent in adults with cancer and common chronic comorbidities such as liver cirrhosis.
- Trial name
- NCT03629444
- Testing
- ct scan
- Volunteers
- 300 people
- Sponsor
- marwa abdElRazek Ahmed sala.a makhlof
Sarcopenia, Sarcopenia in Liver Cirrhosis
Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients
Patients will be informed by obtaining consent when they meet the inclusion criteria. Written consent will be obtained when the patient arrives in the operating room.
- Conditions
- Sarcopenia, Sarcopenia in Liver Cirrhosis, Liver Transplantation
- Trial name
- NCT06909942
- Testing
- Psoas Muscle Index, Handgrip Dynamometer, SARC-F Score
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Inonu University