Clinical trials: Sars-CoV2
Cytokine Storm
The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People
The effect of Weekly 50,000 IU vitamin D3 supplements on the serum levels of selected cytokines involved in cytokine storm of Covid-19; A randomized clinical trial in the Covid-19 uninfected people with vitamin D deficiency.
- Trial name
- NCT04476745
- Testing
- Vitamin D3
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Psychological Distress, COVID
COVID-19 Pandemic Burden in Severe Mental Disease Patients
Despite being originated in Wuhan, in the China mainland region of the Hubei, Italy has been the hardest-hit country in the world by the COVID-19 pandemic during the month of March.
- Conditions
- Psychological Distress, COVID, Severe Mental Disorder
- Trial name
- PsyCOVID (NCT04357769)
- Testing
- PSS (Perceived Stress Scale), GAD-7 (7-item Generalized Anxiety Disorder), PHQ-9 (9-item Patient Health Questionnaire)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University
Long COVID, Long COVID Syndrome
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog…
- Conditions
- Long COVID, Long COVID Syndrome, Long COVID-19 Syndrome, PASC
- Trial name
- MANIFEST (NCT06940609)
- Testing
- accelerated intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
COVID-19
Acalabrutinib Study With Best Supportive Care Versus Best Supportive Care in Subjects Hospitalized With COVID-19.
CALAVI will investigate the safety, efficacy and pharmacokinetics of acalabrutinib together with Best Supportive Care in the treatment of COVID-19.
- Trial name
- CALAVI (NCT04346199)
- Testing
- Acalabrutinib
- Where
- 50 sites in Argentina, Brazil and 12 more
- Volunteers
- 177 people
- Sponsor
- AstraZeneca
Long COVID
Exercise for Health in Patients With Post-acute Sequelae of COVID-19
Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ant…
- Trial name
- EJerSA-COVID (NCT05848518)
- Testing
- Rehabilitation program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
SARS-CoV-2 Infection, Influenza A
Clinical Validation of an At-Home Flu A/B and COVID-19 Rapid Test
The study's primary objective is to evaluate the performance of the CorDx Tyfast Flu A/B \& COVID-19 At-Home Test for detecting SARS-CoV-2, Influenza A, and B in nasal samples collected by lay users, compared to 510(k)-cleared…
- Conditions
- SARS-CoV-2 Infection, Influenza A, Influenza B
- Trial name
- NCT07430410
- Testing
- CorDx Tyfast Flu A/B & COVID-19 At-Home Multiplex Rapid Test
- Volunteers
- 200 people
- Sponsor
- CorDx, Inc.
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
COVID-19
COVID RESPONSE STUDY (COVRES)
This study will undertake recruitment of Covid-19 positive hospitalised and non-hospitalised and nursing home patients, hospital and nursing home staff, for whole genome sequencing, human host genomic analyses and viral genomic…
- Trial name
- COVRES (NCT05548829)
- Testing
- Disease severity
- Where
- United Kingdom
- Volunteers
- 519 people
- Sponsor
- University of Ulster
COVID-19 Acute Respiratory Distress Syndrome, Immunosuppression
Booster Dose of COVID-19 Vaccine for Kidney Transplant Recipients Without Adequate Humoral Response
Introduction: Inadequate antibody response to mRNA SARS-CoV-2 vaccination has been described among kidney transplant recipients.
- Trial name
- WHO (NCT04961229)
- Testing
- The Pfizer mRNA-based BNT162b2 vaccine
- Volunteers
- 504 people
- Sponsor
- dafna yahav
COVID-19
Study to Monitor the Occurrence of Viral Variants in Patients With Compromised Immune Systems Being Treated for COVID-19
Sotrovimab binds to a conserved epitope on the severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 spike protein outside the receptor-binding motif and has been shown to reduce the risk of hospitalization…
- Trial name
- LUNAR (NCT05305651)
- Testing
- Sotrovimab
- Where
- 8 sites in United Kingdom
- Volunteers
- 217 people
- Sponsor
- GlaxoSmithKline
Parent-Child Relations, Parental Stress
Effects of an ACT-based Psychological Treatment in Relatives of People With Intellectual Disabilities
Investigation of the efficacy of Acceptance and Commitment Therapy (ACT) for the psychological treatment of parental stress in relatives of people with intellectual disabilities
- Trial name
- NCT05611554
- Testing
- ACT
- Where
- Spain
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
COVID-19
Adaptive COVID-19 Treatment Trial (ACTT)
This study is an adaptive, randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of novel therapeutic agents in hospitalized adults diagnosed with COVID-19.
- Trial name
- NCT04280705
- Testing
- Remdesivir
- Where
- 60 sites in United States, Denmark and 8 more
- Volunteers
- 1,062 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
COVIDOM: Longterm Morbidity of SARS-CoV-2 Infection and COVID-19 Disease - Consequences for Health Status and Quality of Life
COVID-19 is a novel disease caused by SARS-CoV-2 that primarily affects the lungs but also various other organs of the body already in early stages of the disease.
- Trial name
- NAPKON-POP (NCT04679584)
- Testing
- Observation of different courses of SARS-CoV-2 infection in different phases (acute vs. post-acute) and settings
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Schleswig-Holstein
Covid19
Identification of Differences in Breath Components Detected With IMS in Patients Tested on SARS-CoV-2 (COVID-19)
Breath analysis is the evaluation of exhaled air of humans. It aims to get information about the clinical status of a human being by monitoring its volatile organic compounds (VOCs) in exhaled air.
- Trial name
- NCT04556318
- Testing
- Ion Mobility Spectrometry (IMS)
- Where
- 2 sites in Germany
- Volunteers
- 396 people
- Sponsor
- B. Braun Melsungen AG
COVID-19, COVID
COVID-19 Infection and Machine Learning Using Artificial Intelligence (AI)
COVID-19 infection is currently confirmed by a complex, multiple-step procedure starting with a mucosal swab, followed by viral RNA extraction and processing and qPCR.
- Conditions
- COVID-19, COVID, SARS-CoV 2
- Trial name
- NCT04756518
- Where
- United Kingdom
- Volunteers
- 215 people
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Cancer
Study of the Specific Seroprevalence of SARS-CoV-2 in a Sample of Patients and Salaried Staff From a French Anti-cancer Center at the End of the Containment Period of the SARS-CoV-2 Pandemic
Since March 2020, France has been confronted with the SARS-COV-2 pandemic. Analysis of the data of its spread would indicate that close contact between individuals is necessary and containment would be the best way to contain…
- Trial name
- canSEROcov (NCT04517097)
- Testing
- blood sample
- Where
- France
- Volunteers
- 1,680 people
- Sponsor
- Centre Georges Francois Leclerc
COVID 19
CoVID-19 Plasma in Treatment of COVID-19 Patients
The investigatores propose to evaluate intravenous administration of convalescent plasma (CP) obtained from COVID19 survivors in patients requiring hospitalization for symptomatic "high risk" COVID19 disease as reflected by the…
- Trial name
- NCT04355897
- Testing
- Convalescent COVID 19 Plasma
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- The Christ Hospital
COVID-19
Safety, Tolerability and Immunogenicity of Recombinant COVID-19 Vaccine Betuvax-CoV-2
Randomized, double-blind, multicenter parallel-group clinical study of safety, tolerability and immunogenicity of the Betuvax-CoV-2 vaccine.
- Trial name
- Betuvax-CoV2 (NCT05270954)
- Testing
- Betuvax-CoV-2
- Where
- 3 sites in Russia
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Artgen Biotech
Long COVID, Chronic Fatigue Syndrome
tVNS in Long COVID-19
A prior open label study has shown that transcutaneous vagus nerve stimulation [tVNS] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill…
- Trial name
- NCT06585254
- Testing
- Transcutaneous vagus nerve stimulator
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Severe Acute Respiratory Syndrome Coronavirus 2, Acute Respiratory Distress Syndrome
Pulmonary Fibrosis During Severe COVID-19 Pneumonia
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), an emerging coronavirus, which has already infected 192 million people with a case fatality rate close to 2%.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Acute Respiratory Distress Syndrome, Pulmonary Fibrosis
- Trial name
- FIBRO-COVID (NCT04987528)
- Testing
- Aminoterminal type III peptide of procollagen, Lung computed tomography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hôpital Européen Marseille