Clinical trials: Scarred Uterus
Cesarean Section Complications, Scar Niche
Uterine Scar Resection During Repeat Cesarean Delivery to Prevent Uterine Niche Formation
The purpose of the study is to evaluate whether resection of the previous cesarean scar at repeat cesarean delivery reduces uterine niche formation and related morbidity without increasing operative risks.
- Conditions
- Cesarean Section Complications, Scar Niche, Scarred Uterus
- Trial name
- NCT07228858
- Testing
- Repeated cesarean section with previous uterine cesarean section scar resection, Repeated cesarean section without uterine scar resection, Saline-infusion Sonohysterography
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Benha University
Uterine Scar
Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars
The purpose of this study is to evaluate the safety of umbilical cord mesenchymal stem cell local intramuscular injection for treatment of uterine scars by a prospective, single-center, open, and single-arm clinical trial.
- Trial name
- NCT03181087
- Testing
- Umbilical cord MSCs
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Foshan
Cesarean Scar Defect (Isthmococele)
Incision-Parallel Double-Layer Non-Locking Versus Single-Layer Locked Uterine Closure After Primary Caesarean Delivery: A Randomized Controlled Trial
This randomized controlled trial was conducted to compare two uterine closure techniques in women undergoing primary cesarean delivery.
- Trial name
- NCT07841028
- Testing
- Single-Layer Locked Uterine Closure, Double-Layer Incision-Parallel Nonlocking Uterine Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Onur Karaaslan
Scar; Previous Cesarean Section
Assessing the Stability of Uterine Scar Tissue in Women With Previous History of Caesarean Section Using Multimodal Analyses of the Lower Uterine Segment Including Quantitative Sonography
This prospective, clinical, observational trial compares the measured value with quantitative ultrasonic (preoperatively) Elastic modulus E (kPA) with the measured value with quantitative ultrasonic Elastic modulus E (kPA) in…
- Trial name
- QUANTUSLUS (NCT02827591)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Cesarean Section; Dehiscence
Ultrasound Based Study For Niche Development In The Uterine Cesarean Section Scar
The aim of this study is to evaluate different factors affecting niche development in the uterine cesarean section scar in women enrolled 3 to 6 months after cesarean delivery using both TVS and SIS.
- Trial name
- NCT03859258
- Testing
- Transvaginal sonography
- Where
- Egypt
- Volunteers
- 221 people
- Sponsor
- Cairo University
Isthmocele, Uterine Scar Defects
Cesarean Scar Defects After Uterine Closure by Double-layer Barbed or Smooth Suture
Late sequelae of a cesarean section related to a uterine scar defects include gynecological symptoms and obstetric complications.
- Conditions
- Isthmocele, Uterine Scar Defects, Cesarean Section Complications, Uterine Niche
- Trial name
- NCT04825821
- Testing
- Clinical and ultrasonographic assessment
- Where
- Italy
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Uterine Niche
Laparoscopic Versus Transvaginal Approaches in Repair of Uterine Niche: A Randomized Controlled Trial
The treatment of uterine niche ranges from clinical management with expectant or pharmacological treatment, surgical treatment. Approaches for repair include Laparotomy, laparoscopy , hysteroscopy , vaginal.
- Trial name
- isthmocele (NCT04241107)
- Testing
- Laparoscopic repair of Uterine niche, Transvaginal repair of Uterine niche
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Uterine Scar
Comparison Of Suture Materials on Sectio Scars (COSMOSS)
This multicenter prospective randomized controlled trial aims to investigate the ishtmocele rates after c-section delivery depending on using different suture materials for the uterine closure.
- Trial name
- COSMOSS (NCT05096910)
- Testing
- Uterine Closure with monofilament or polyfilament suture materials
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uludag University
Cesarean Section; Dehiscence, Cesarean Scar Niche
Effect of Alpha Lipoic Acid on Uterine Scar Healing After Cesarean Section
The aim of this study is to evaluate the efficacy of alpha lipoic acid on uterine scar healing after cesarean section by using saline contrast sonohysterography
- Trial name
- NCT03257514
- Testing
- alpha lipoic acid drug (thioctic acid acid)
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Magnetic Resonance Imaging, Ovarian Function
Fertility After Transvaginal Surgery or Uterine Artery Embolization Combined With Uterine Curettage in Patients With Cesarean Scar Pregnancy
To investigate the fertility in patients after treatment by transvaginal surgery or uterine artery embolization combined with uterine curettage
- Conditions
- Magnetic Resonance Imaging, Ovarian Function, Menstruation
- Trial name
- NCT02933190
- Testing
- transvaginal surgery；UAE and D&C
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Adhesion; Uterus, Internal
Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)
Patients suffering of subfertility as a consequence of intrauterine adhesions could be treated with hysteroscopic adhesiolysis. Adhesion recurrence may occur postoperative.
- Trial name
- NCT03446755
- Testing
- intra uterine Cook balloon
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Induction of Abortion, Scarred Uterus
Laminaria Japonicum Followed by Misoprostol Versus Misoprostol Alone for Mid-Trimester Abortion Induction in Scarred Uterus
The goal of this clinical trial is to compare the induction-to-abortion time interval between women receiving Laminaria tent followed by misoprostol and those receiving misoprostol alone for mid-trimester abortion induction in…
- Trial name
- Obstetrics (NCT07465016)
- Testing
- Misoprostol ( Cytotec) 200 microgram a tablet, Laminaria Tent
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Pavly Maged Jimmy Fouad
Adhesions Pelvic, Adhesion; Uterus
Prediction of Vesicouterine Adhesions by Transvaginal Sonographic Sliding Sign Technique: a Validation Study
The aim of this study is to evaluate the predictive value of the real-time dynamic TVS sliding sign for vesicouterine pouch adhesions in women and to test the inter- and intraobserver agreement of this new technique.
- Conditions
- Adhesions Pelvic, Adhesion; Uterus, Adhesion; Bladder
- Trial name
- NCT05862155
- Where
- Netherlands
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Cesarean Scar Diverticulum
A Randomized Controlled Study of Uterine Incision Diverticulum Repair vs. no Repair During Second/Third Cesarean Section
The goal of this study is to assess the efficacy and safety of uterine incision diverticulum repair during repeat cesarean section.The main questions it aims to answer are: Can this surgical method improve the symptom of…
- Trial name
- NCT06612957
- Testing
- Repair of uterine cicatricial diverticulum
- Volunteers
- 60 people
- Sponsor
- Shanghai First Maternal and Infant Health Hospital affiliated to Tongji University Medical School
Scar Niche, Myometrial Remodeling
Postplacental Copper Intrauterine Device Versus Postpartum Progesterone-only Pills on Uterine Niche Formation
The purpose of the study is to determine whether immediate postplacental copper T380A intrauterine device insertion increases uterine-niche incidence compared with postpartum progestin-only pills after primary cesarean section .
- Conditions
- Scar Niche, Myometrial Remodeling, Contraceptive Device; Complications, Cesarean Section Complications
- Trial name
- T380A (NCT07264933)
- Testing
- Primary Cesarean Section, immediate postplacental insertion of a copper T380A intrauterine device, progesterone-only pills
- Where
- Egypt
- Volunteers
- 750 people
- Sponsor
- Benha University
Intermenstrual Bleeding
Nonsurgical Management of Cesarean Scar Niche Related Abnormal Uterine Bleeding
A study of the effect of three different nonsurgical methods for management of abnormal uterine bleeding caused by cesarean scar niche.
- Trial name
- NCT05594186
- Testing
- Tranexamic acid, Oral contraceptive pills and the Levonorgestrel-releasing intrauterine system.
- Where
- Saudi Arabia
- Volunteers
- 158 people
- Sponsor
- Saudi German Hospital - Madinah
Scar; Previous Cesarean Section
Preoperative and Intraoperative Sonographic Assessment of Lower Uterine Segment Thickness at Term in Women With Previous Cesarean Delivery - a Ultrasound Method Comparison Study
This prospective, clinical, observational study compares preoperative and intraoperative sonographic assessment of lower uterine segment of women who underwent ≥ second cesarean section.
- Trial name
- SALUTARY (NCT02827604)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Laser-Induced Scar, Breast Cancer
Laser Treatment of Genito-urinary Syndrome in Women
Women with genitourinary syndrome of menopause, overactive bladder, with breast or endometrial cancer are randomized to either laser treatment og sham treatment for 3 months.
- Conditions
- Laser-Induced Scar, Breast Cancer, Endometrial Cancer, Menopause
- Trial name
- NCT03238053
- Testing
- Vaginal laser treatment, laser system
- Where
- Denmark
- Sponsor
- Herning Hospital
Myoma;Uterus, Adhesion; Uterus, Internal
Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel
This prospective randomized study aims to evaluate whether the application of an intrauterine anti-adhesion gel reduces the incidence of intrauterine adhesions (IUAs) following robotic-assisted laparoscopic myomectomy.
- Trial name
- NCT07280286
- Testing
- Women will receive the application of an anti-adhesion gel at the end of the myomectomy procedure
- Volunteers
- 62 people
- Sponsor
- Federico II University
Quality of Life, Sexual Activity
Quality of Life and Sexual Function of Vaginal Operation in The Treatment Of Previous Cesarean Scar Defect
The aim of this study is to further demonstrate the safety , validity and quality of (sexual)life of vaginal operation for previous cesarean scar defect resection.
- Trial name
- PCSD (NCT01978067)
- Testing
- transvaginal resection of Uterine Scar
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shu-Qin Chen