Clinical trials: Schistosomiasis Mansoni
HIV/AIDS
Safety and Immunogenicity Study of a DNA Vaccine Combined With Protein Vaccine Against HIV/AIDS
The primary objective of the proposed phase I trial is to evaluate the safety and tolerability of DNA-HIV-PT123 and AIDSVAX®B/E combination regimen.
- Trial name
- EV06 (NCT02376582)
- Testing
- DNA, AIDSVAX B/E
- Where
- 2 sites in Uganda
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- EuroVacc Foundation
Schistosomiasis, Anemia
Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their…
- Conditions
- Schistosomiasis, Anemia, Underweight, Stunting
- Trial name
- SchistoVAN (NCT01553552)
- Where
- Senegal
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
Schistosoma Mansoni
A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni
The purpose of this study is to determine the comparative efficacy of artesunate plus sulfamethoxypyrazine-pyrimethamine versus Praziquantel in the treatment of school children infected with S.mansoni in western Kenya.
- Trial name
- NCT01054651
- Testing
- Artesunate+Sulfamethoxypyrazine/pyrimethamine, Praziquantel
- Where
- Kenya
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Tuberculosis
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality and morbidity; development of an effective…
- Trial name
- TB036 (NCT02178748)
- Testing
- MVA85A
- Where
- Uganda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Schistosomiasis, Schistosoma Mansoni
Single-sex Controlled Human Schistosomiasis Infection: Safety and Dose Finding
Groups of 3 or 7 volunteers will be exposed to a predetermined number of male Schistosoma mansoni cercariae until 10 volunteers are found infected.
- Trial name
- NCT02755324
- Testing
- male Schistosoma mansoni cercariae
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Leiden University
Schistosomiasis Mansoni, Schistosomiasis Haematobium
Anti-Schistosomiasis Sm14-vaccine in Senegal
Previous clinical trials have already demonstrated the safety of the candidate vaccine in adults as well as in children, in good health or infected with schistosomiasis.
- Conditions
- Schistosomiasis Mansoni, Schistosomiasis Haematobium, Vaccination; Infection
- Trial name
- NCT05658614
- Testing
- Sm14 recombinant vaccine+ GLA-SE adjuvant
- Where
- Senegal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Schistosomiasis, Schistosoma Mansoni
Repeated Controlled Human Schistosoma Mansoni Infection
A group of 24 healthy volunteers are challenged one or three times with 20 male Schistosoma mansoni cercariae to investigate whether this leads to protection and to identify potential correlates of protection
- Trial name
- NCT05085470
- Testing
- Schistosoma mansoni infection
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Schistosoma Mansoni
Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni
Schistosomiasis is classified as among the world's neglected tropical diseases (NTD). Morbidity due to Schistosoma mansoni (S. mansoni) is greatest among school-age children who typically have the highest burden of infection.
- Trial name
- NCT04679831
- Testing
- Ujiplus®, Praziquantel 400mg
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Intestinal Schistosomiasis
Schistosoma Mansoni Morbidity in Children Aged 1-5 Years
This study is about intestinal schistosomiasis, commonly known as bilharzia, in children aged 1-5 years along Lake Victoria shoreline.The children will be screened for S.
- Trial name
- NCT01901484
- Testing
- Praziquantel
- Where
- Uganda
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Makerere University
Schistosomiasis, Malaria
The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda
The overall objective of the project is to contribute to an increased knowledge about the effect of praziquantel on schistosomiasis related morbidity and re-infection level among communities living along Lake Victoria in Mayuge…
- Trial name
- NCT00215267
- Testing
- praziquantel
- Where
- Uganda
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Soil Transmitted Helminths, Schistosomiasis Mansoni
Evaluation of an AI-DP for STH Deworming Programs: a Study Protocol
The goal of this observational study is to test a new AI diagnostic tool for detection, specification and quantification of parasitic infections (Ascaris, Trichuris, hookworm and S.
- Trial name
- KAKADU (NCT06055530)
- Testing
- Artificial Intelligence Digital Pathology
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Enaiblers AB
Schistosomiasis Mansoni
Female Genital Schistosomiasis in Tanzania
A cross-sectional survey will be conducted among 200 volunteering women aged 18- 45 years and having had prior sexual activity living in the target villages of Itilima and Maswa districts, North-western Tanzania.
- Trial name
- ShWAB (NCT05788003)
- Testing
- self-collected and operator-collected swab followed by molecular analysis
- Where
- 2 sites in Italy, Tanzania
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Schistosomiasis
Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children
The clinical trial phase 2b is designed to assess the safety and the specific immune response of the active ingredient (protein + adjuvant) in healthy and then in infected school children from 8 to 11 years of age with intestinal…
- Trial name
- NCT03799510
- Testing
- Sm14, GLA-SE solution
- Where
- Senegal
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Anemia, Intestinal Helminthiasis
A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
In this study, it is hypothesized that helminth infections modulate immune responses against HIV-1 infection resulting into increased HIV-1 multiplication, faster progression to AIDS and increased episodes of AIDS-related…
- Conditions
- Anemia, Intestinal Helminthiasis, Intestinal Schistosomiasis, Human Immunodeficiency Virus I Infection
- Trial name
- NCT01541631
- Testing
- Praziquantel and Albendazole
- Where
- 2 sites in Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Catholic University of Health and Allied Sciences
Schistosomiasis, Schistosomiasis Mansoni
Single-sex Female Controlled Human Schistosomiasis Mansoni Infection
Groups of 3 or 7 volunteers will be exposed to a predetermined number of female Schistosoma mansoni cercariae until 10 volunteers are found infected.
- Trial name
- NCT04269915
- Testing
- female Schistosoma mansoni cercariae
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Schistosomiasis
A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults
This is a Phase I, first-in-human study of a vaccine against S. mansoni infection.The study will recruit 72 healthy adult males and non-pregnant females from a single clinical center to test two formulations of Sm-TSP-2 vaccine…
- Trial name
- NCT02337855
- Testing
- Sm-TSP-2/Alhydrogel, Sm-TSP-2/Alhydrogel/GLA-AF
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Schistosoma Mansoni
Leiden University Medical Center Mini Donor Bank
(Bio)medical research, particularly immunological, metabolic, transcriptional or biological assays, occasionally require the use of fresh blood (peripheral mononuclear cells) or urine.
- Conditions
- Malaria, Schistosoma Mansoni, Schistosoma Haematobium, Diabetes
- Trial name
- NCT02810613
- Volunteers
- healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Schistosomiasis, Schistosomiasis Mansoni
Praziquantel in Children Under Age 4
The overall goals of this proposal are to conduct a trial to address the significant gaps with respect to our understanding of best approaches to treatment of children ages 1-4 with intestinal schistosomiasis.
- Conditions
- Schistosomiasis, Schistosomiasis Mansoni, Schistosoma Japonicum Infection
- Trial name
- PIP (NCT03640377)
- Testing
- Praziquantel
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Schistosoma Mansoni, Schistosomiasis
Sm-p80 Schistosomiasis Challenge Study
The goal of this clinical trial is to learn about the Sm-p80 + GLA-SE (Schistoshield®) vaccine in healthy participants who have not had schistosomiasis before.
- Trial name
- NCT05999825
- Testing
- Sm-p80 + GLA-SE Vaccine, Schistosoma mansoni infection
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Schistosomiasis
Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions
The clinical trial phase 2a is designed to assess the safety of the active ingredient (protein + adjuvant) and secondarily its immunogenicity in healthy male adults from 18 to 49 years of age with a history of infection with…
- Trial name
- NCT03041766
- Testing
- Sm14, GLA-SE solution
- Where
- Senegal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation