Clinical trials: Schizophrenia Disorders
Schizophrenia
Seroquel on Glucose Metabolism
The purpose of this study is to determine whether six months treatment with the antipsychotic medicine Seroquel (quetiapine) may affect the schizophrenic patient's glucose metabolism
- Trial name
- NCT00214578
- Testing
- Seroquel (quetiapine)
- Where
- 70 sites in Bulgaria, Czechia and 7 more
- Volunteers
- 572 people
- Sponsor
- AstraZeneca
Schizophrenia
Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT)
This study is a sequential multiple-assignment randomized trial (RCT) of antipsychotic medication treatment in first-episode schizophrenia patients in the real-world settings.Through analysis of treatment efficacy rate and…
- Trial name
- NCT03510325
- Testing
- Phase 1: Olanzapine, Phase 1: Risperidone, Phase 1: Amisulpride
- Where
- 7 sites in China
- Volunteers
- 762 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
A Study of Paliperidone Blood Concentrations in Patients With Schizophrenia After Administration of Paliperidone Palmitate
The purpose of this study is to evaluate the concentration of paliperidone in the blood after intramuscular injection in upper arm (deltoid muscle) or in the buttock (gluteal muscle) in patients with schizophrenia.
- Trial name
- NCT01110317
- Testing
- paliperidone palmitate 100 mg
- Volunteers
- 49 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Insomnia, Psychosis
CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes
The goal of this project is to develop guidelines for the clinical tailoring of Cognitive Behavioral Therapy for Insomnia (CBT-I) for Veterans with psychotic disorders and insomnia, and to test the acceptability, feasibility, and…
- Trial name
- CBT-I (NCT02535923)
- Testing
- Cognitive Behavioral Therapy-Insomnia, Health and Wellness
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan
This proposal responds to Request for Applications RFA-MH-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the NIMH Human Genetics Initiative and to apply genomic methods to…
- Trial name
- NCT01357005
- Testing
- No intervention would be provided in this research
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Schizophrenia, Schizoaffective Disorder
Acute Psychosis Treatment in the Long Term, Unitary Group Study (APLUS)
The purpose of this study is to prove safety and efficacy of aripiprazole.
- Trial name
- NCT00304655
- Testing
- Aripiprazole
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Schizophrenia Spectrum & Other Psychotic Disorders
PACT for Individuals With Serious Mental Illness
People with serious mental illness have difficulty making good use of primary care, and die, on average, years earlier than others in the population.
- Trial name
- SMI-PACT (NCT01668355)
- Testing
- Patient Aligned Care Team (PACT)
- Where
- 3 sites in United States
- Volunteers
- 331 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Schizophrenia
Diabetes Screening, Risk Management and Disease Management in a High-Risk Mental Health Population Part II
The purpose of this study is to learn more about the relationship between serious mental illness and the detection and management of diabetes and pre-diabetic conditions.
- Conditions
- Diabetes Mellitus, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00377117
- Testing
- Management, Screening
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy
Study Of The PF-04958242 Blood Concentrations Of A Capsule Formulation Of PF-04958242 Compared To A Solution Formulation
This study will assess the relative bioavailability of a capsule formulation of PF-04958242, relative to a oral solution formulation of PF-04958242 in healthy adult subjects.
- Trial name
- NCT01646840
- Testing
- PF-04958242 capsule, PF-04958242 oral solution
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Biogen
Schizophrenia and Related Disorders
Clay Therapy in Schizophrenia Patients
In recent years, art therapies have been discussed for their positive effects on mental disorders. One such therapy, clay therapy, is being studied to examine its effect on the functional recovery and individual and social…
- Trial name
- NCT07378150
- Testing
- Clay therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Kutahya Health Sciences University
Psychosis, Schizoaffective Disorder
OnTrack>An Online Role-Playing Game for Young People With First Episode Psychosis
The research team will develop and test a prototype version of OnTrack>An Online Role-Playing Game (OnTrack>The Game or OTG), an online role-playing game designed for youth and young adults experiencing First Episode Psychosis…
- Conditions
- Psychosis, Schizoaffective Disorder, Schizophrenia
- Trial name
- NCT03390491
- Testing
- OnTrack>TheGame (OTG), Recovery Videos (RV)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Schizophrenia
The Effects of Prebiotics on Cognitive Functioning and Weight Gain in Psychosis
The investigators propose a maltodextrin-controlled cross over experimental medicine study that aims to examine the role of the immune system in cognitive processes and weight gain in 40 adult patients with psychosis, stable on…
- Trial name
- Prepsy (NCT03153046)
- Testing
- prebiotics, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Oxford
Schizophrenia
Creating Live Interactions to Mitigate Barriers
This study is a validation study to evaluate the acceptability, feasibility and impact of a mobile psychosocial intervention to enhance social functioning in people with schizophrenia.
- Trial name
- CLIMB (NCT03317769)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Optimized social skills training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Psychotic Disorders
Serial Comparisons of Abdominal and Neurological MRI Scans
The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
- Trial name
- SCANMRI (NCT02009969)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Tobacco Use Disorder, Schizophrenia
Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
This project tests two hypotheses concerning the low smoking cessation rates in smokers with schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger and more sustained effects of smoking…
- Trial name
- WREN (NCT01214005)
- Testing
- smoking abstinence
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Schizophrenia
Long Acting Paliperidone in Dually Diagnosed People With Schizophrenia: An Open-label Pilot Study
Comorbid substance abuse leads to many deleterious effects such as medical comorbidities and nonadherence, which is one of the most problematic issues.
- Trial name
- NCT01584466
- Testing
- Paliperidone
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Schizophrenia and Disorders With Psychotic Features
Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia
Sorghum bicolor is a naturally growing plant which has been of health benefit to the people of West Africa who traditionally prepare its leaf for various nutritional and health reasons.The food and nutritional fact analysis…
- Trial name
- NCT02240173
- Testing
- Jobelyn, Haloperidol
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Federal Neuro-Psychiatric Hospital, Yaba
Schizophrenia
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia
The purpose of study is to determine whether dietary supplement sarcosine is effective in treatment of schizophrenia. The investigators will assess impact of sarcosine on quality of life and sexual functioning.
- Trial name
- PULSAR (NCT01503359)
- Testing
- Sarcosine
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Lodz
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia
Adjunctive Selective Estrogen Receptor Modulators on Negative and Cognitive Symptoms of Schizophrenia in Women
The aim of the project is to assess the efficacy of Adjunctive Selective Estrogen Receptor Modulators (Raloxifene) on Negative and Cognitive symptoms of Schizophrenia in Postmenopausal Women.
- Trial name
- NCT03418831
- Testing
- Raloxifene Hydrochloride
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Mental Health Center