Clinical trials: Schizophrenia and Related Disorders
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Schizoaffective Disorder, Schizophrenia
Smoking Cessation for Veterans With Severe and Persistent Mental Illness
The investigators have developed an intervention called Behavioral Treatment of Smoking Cessation in SPMI (BTSCS), an innovative intervention that supplements pharmacotherapy and education with contingency management and a…
- Conditions
- Schizoaffective Disorder, Schizophrenia, Affective Psychosis, Bipolar, Affective Disorders, Psychotic
- Trial name
- NCT00960375
- Testing
- BTSCS, StSST
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizoaffective Disorder
Neurophysiological Studies in Schizophrenia and Psychiatric Disorders
The overall goal of this project is to identify intermediate phenotypes for psychosis across the schizophrenia and bipolar disorders boundary with implications for future genetic studies.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- BSNIP (NCT01384604)
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
High Triglycerides, Hypercholesterolemia
Omega-3 Fatty Acids (Lovaza) for Second Generation Antipsychotic-Associated Hypertriglyceridemia
This is an open-label pilot study of omega-3 fatty acids (Lovaza) for hypertriglyceridemia in subjects who have been on an atypical (second-generation) antipsychotic medication.
- Conditions
- High Triglycerides, Hypercholesterolemia, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT00833976
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post-Traumatic
Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses
The purpose of this study is to develop an effective treatment for people with Post Traumatic Stress Disorder (PTSD) along with other mental illnesses.
- Trial name
- NCT00053690
- Testing
- Cognitive Behavior Treatment
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychosis, Schizophrenia
Enhanced Coordinated Specialty Care for Early Psychosis
The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis.
- Conditions
- Psychosis, Schizophrenia, Schizoaffective Disorder, Psychosis Nos/Other
- Trial name
- NCT06071858
- Testing
- Care Coordination, Individual Peer Support, Digital Outreach
- Where
- 5 sites in United States
- Volunteers
- 350 people
- Sponsor
- Mclean Hospital
Schizophrenia, Schizoaffective Disorder
AIMHI NT Relapse Prevention Trial
A new treatment for indigenous people with mental illness in remote communities has been developed. The study hypothesis is that this new treatment will result in better outcomes for clients and carers than the outcomes of…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychoses, Substance Induced, Depression
- Trial name
- NCT00192582
- Testing
- Motivational Interview with care plan and education
- Where
- Australia
- Volunteers
- 90 people
- Sponsor
- Menzies School of Health Research
Schizophrenia, Bipolar Disorder
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness
The goal of this clinical trial is to learn about how a digital training platform can enhance implementation and effectiveness of a validated mHealth system, called FOCUS, in people with serious mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Schizo Affective Disorder
- Trial name
- NCT05725785
- Testing
- FOCUS participants
- Where
- 3 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bipolar Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental III Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Bipolar Disorder, Schizophrenia, Severe Depression
- Trial name
- RECOVER-E (NCT03922425)
- Testing
- Community mental health team
- Where
- Bulgaria
- Volunteers
- 180 people
- Sponsor
- The National Center for Public Health and Analyzes, Bulgaria
Schizophrenia, Cancer
Association Between Schizophrenia and Cancer
A family study of the negative association betweeen schizophrenia and cancer
- Trial name
- NCT00419016
- Sponsor
- Sheba Medical Center
Schizophrenia, Bipolar Disorder
Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?
Wide ranging cognitive deficits are major drivers of functional decline and poor outcomes in people with schizophrenia (SZ) and bipolar disorder (BD).
- Trial name
- NCT05268809
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Northern California Institute of Research and Education
Schizophrenia, Metabolic Syndrome
Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia
We are going to investigate the association of multiple genetic polymorphisms with the metabolic side effects in patients with schizophrenia taking clozapine.
- Conditions
- Schizophrenia, Metabolic Syndrome, Genetic Polymorphism
- Trial name
- NCT00717509
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National Hospital
Metabolic Complications
Metformin for the Prevention of the Metabolic Side-effects of Zyprexa
We hypothesize that metformin co-administered with olanzapine will be well tolerated and associated with significantly less insulin resistance, weight gain and dyslipidemia as compared to olanzapine plus placebo.
- Trial name
- NCT00682448
- Testing
- Metformin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rush University Medical Center
Schizophrenia and Related Disorders
"InMotion" - Physical Training With Creative Movement as an Intervention for Adults With Schizophrenia
InMotion is a randomized controlled study where adults with schizophrenia and schizophrenia-similar conditions, will be recruited to receive physical training with creative movements as an intervention, twice a week for a period…
- Trial name
- InMotion (NCT05673941)
- Testing
- Creative physical training
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Parkinson's Disease
A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease
The major purpose of the Stage 1 is to study the safety and tolerability of the proposed dosage regimen of the study drug. The form of cannabidiol (CBD) used in this study is GWP42003, supplied by GW Pharmaceuticals.
- Trial name
- NCT02818777
- Testing
- cannabidiol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Schizophrenia and Related Disorders, Early Treatment-Resistance
The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Schizophrenia (SZ) affects approximately 4.5 million people across the European Union (EU) and is associated with annual healthcare and societal costs of 29 billion Euros.
- Trial name
- INTENSIFY SZ (NCT05958875)
- Testing
- Clozapine, Second-line Antipsychotics (treatment as usual)
- Where
- 13 sites in Austria, Germany and 3 more
- Volunteers
- 418 people
- Sponsor
- Dr. Inge Winter
Schizophrenia and Related Disorders
Transcranial Magnetic Stimulation to Improve Gesture Control
The majority of schizophrenia patients is impaired in hand gesture performance, which contributes to poor functional outcome and poor communication skills.
- Trial name
- GestTMS (NCT03483909)
- Testing
- left IFG iTBS, right IPL cTBS
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bern
Schizophrenia, Schizoaffective
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
This is a 15 week trial to determine (1) the safety and tolerability of varenicline when used for smoking cessation/reduction in individuals with schizophrenia; (2) if treatment with varenicline affects the symptoms of…
- Conditions
- Schizophrenia, Schizoaffective, Psychosis
- Trial name
- NCT00702793
- Testing
- Varenicline
- Sponsor
- University of British Columbia
Schizophrenia, Bipolar Disorders
Feeling of Being in Control of One's Own Action
The investigators aim is to understand the cognitive mechanisms that contribute to the emergence of delusions of control (the belief that one's own actions or thoughts are controlled by an external force).
- Trial name
- NCT01312649
- Testing
- Experimental psychology methods (computer tests)
- Where
- France
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Mental Illness, Schizophrenia
Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMI
People who have a severe mental illness can have poorer physical health and higher mortality rates than the general population. Their medications combined with low levels of physical activity and increased sedentary behaviour can…
- Conditions
- Mental Illness, Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- WORtH (NCT04134871)
- Testing
- Group walk and one to one coaching
- Where
- 3 sites in Ireland, United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Ulster