Clinical trials: Schizophrenia and Related Disorders
Mental Illness, Schizophrenia
Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMI
People who have a severe mental illness can have poorer physical health and higher mortality rates than the general population. Their medications combined with low levels of physical activity and increased sedentary behaviour can…
- Conditions
- Mental Illness, Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- WORtH (NCT04134871)
- Testing
- Group walk and one to one coaching
- Where
- 3 sites in Ireland, United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Ulster
Cancer, Severe Major Depression
Adapting the Tumor Board Model for Mental Illness and Cancer
This study examines the feasibility and acceptability of a virtual tumor board for cancer and mental illness for patients with serious mental illness and a new cancer diagnosis.
- Conditions
- Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- NCT05837598
- Testing
- Virtual Cancer and Mental Health Tumor Board
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia and Related Disorders, Immune Suppression
The Norwegian Prednisolone in Early Psychosis Study
Objective: The primary objective of this trial is to investigate whether prednisolone improves symptom severity as compared to placebo when given in addition to antipsychotic medication to patients with early-stage psychotic…
- Conditions
- Schizophrenia and Related Disorders, Immune Suppression, Psychosis, Cognitive Change
- Trial name
- NorPEPS (NCT03340909)
- Testing
- Prednisolone
- Where
- 3 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Haukeland University Hospital
Mental Disorder in Adolescence, Bipolar Disorder
Investigation of the Effects of Family-Focused Therapy in the Early Period of Bipolar Disorder and Psychotic Disorder
Family-focused therapy (FFT) is a comprehensive therapy approach applied to individuals and their families. In the present study, the researchers aimed to investigate the effects of family-focused therapy (FFT) in the early…
- Conditions
- Mental Disorder in Adolescence, Bipolar Disorder, Psychosis, Family Relations
- Trial name
- NCT05809193
- Testing
- Family-Focused Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Dokuz Eylul University
Schizophrenia, Schizo Affective Disorder
Financial Incentives to Improve Medication Adherence
Medication adherence is a challenge in all of medicine and is associated with multiple negative outcomes. Strategies to better measure and enhance adherence to medication are urgent and necessary to minimize unwanted health…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder, Depression
- Trial name
- NCT04191876
- Testing
- Wellth - Financial Incentives
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Schizophrenia, Schizoaffective Disorder
Exercise and Cognitive Training
The purpose of this study is to evaluate the potential benefits of combining cognitive remediation and exercise in improving cognitive functioning and response to psychiatric rehabilitation.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02326389
- Testing
- Exercise, Cognitive Remediation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston University Charles River Campus
Schizophenia Disorder, Severe Mental Illness
Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness
Severe mental illness (SMI), including schizophrenia spectrum disorders and bipolar disorder, is associated with significant impairments in psychosocial functioning, daily life participation, self-efficacy, and social…
- Conditions
- Schizophenia Disorder, Severe Mental Illness, Bipolar Disorder, Nonorganic Psychosis
- Trial name
- OT-SMI (NCT07879118)
- Testing
- Occupational Therapy Group Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Schizophrenia
A Double-Blind Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Negative Symptoms in Schizophrenia
There is pilot data to suggest the therapeutic value of rTMS applied to the left prefrontal cortex in the treatment of negative symptoms.
- Trial name
- rTMS (NCT00168311)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Australia
- Volunteers
- 22 people
- Sponsor
- The Alfred
Schizophrenia, Bipolar Disorder
Restoration of Cognitive Function With TDCS and Training in Serious Mental Illness
Development of interventions that can effectively target and remediate the cognitive and functional impairment associated with serious mental illness is a treatment priority.
- Conditions
- Schizophrenia, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- NCT03208036
- Testing
- TDCS, Cognitive Remediation, Bridging Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Healthy
Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I
The overall purpose of this study is to examine the effect of Pregnenolone (PREG) on the acute psychosis-like and cognitive effects of Delta-9-Tetrahydrocannabinol (THC).
- Trial name
- THC-PREG-I (NCT02811939)
- Testing
- Active Dronabinol, Active Pregnenolone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Cocaine Dependence
A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence
The purpose of this study is to gather systematic clinical data on whether aripiprazole, a partial dopamine agonist, beneficially affects schizophrenia plus cocaine dependence subjects.
- Trial name
- NCT00737256
- Testing
- Aripiprazole, Perphenazine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Paul Saenger
Bipolar Disorder, Schizophrenia
Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?
The initial aim of the project was to gain an understanding of the comprehension of "language-oriented" emotions among schizophrenic and bipolar patients.
- Trial name
- ELISE (NCT02805088)
- Testing
- Electroencephalographic recordings, neuropsychological evaluation, clinical evaluation of symptoms
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Emotional Dysregulation
Patients Suffering From Emotional Dysregulation
Emotional dysregulation (ED) is a common syndrome in psychiatric disorders. It is characterized by intense emotions, easily triggered, and with significant psychological impact: explosions of anger, irritability, impulsivity…
- Trial name
- Dys-Emotion (NCT06616337)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Schizophrenia, Undifferentiated, Anorexia
Representations and Strategies for Recovery
In the recent context of deinstitutionalization and longitudinal studies pointing to a large number of positive long-term outcommes for people affected by a psychiatric disorder (schizophrenia, bipolar disorder, eating disorder…
- Conditions
- Schizophrenia, Undifferentiated, Anorexia, Bipolar Disorders, Personality Disorders
- Trial name
- EPR (NCT03028545)
- Testing
- Collection of the individual narrative, semi-directed interviews
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hôpital le Vinatier
Trauma, Psychological, Psychosis
A Comprehensive Third-generation Intervention for People With Psychosis and Post-traumatic Stress Symptoms
Existing data suggest that both trauma and Post-Traumatic Stress Disorder (PTSD) are very common among individuals with psychosis.
- Trial name
- IITG-PPT (NCT05619822)
- Testing
- TAU + A comprehensive third-generation intervention, TAU
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Stigma
Internalized Stigma in Patients With Bipolar Disorder or Schizophrenia
The aim of this study is to explore the levels of internalized stigma in a sample of young patients with bipolar disorder or schizophrenia.
- Trial name
- ESTINT (NCT01664884)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Alcohol Dependence, Schizophrenia
Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism
The aim of this study is to evaluate the safety and efficacy of acamprosate for patients with alcohol dependence and comorbid schizophrenia spectrum disorders.
- Trial name
- NCT00463346
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Schizophrenia, Schizoaffective
Psychiatric Advance Directives for Improved Mental Health Care
During a psychiatric crisis, persons with severe mental illness (SMI) confront complex challenges concerning treatment choices and are often ill equipped or unable to make mental health care decisions.
- Conditions
- Schizophrenia, Schizoaffective, Bipolar Disorder, Stress Disorders, Post-traumatic
- Trial name
- NCT00105794
- Testing
- Psychiatric Advance Directives intervention
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- US Department of Veterans Affairs
Psychotic Disorders, Schizophrenia
Pentosan Polysulfate Sodium and Meclofenamic Acid as Treatments in Patients With Psychotic Disorders
This study evaluates the feasibility of administering meclofenamic acid or pentosan polysulfate sodium as an adjunctive treatment to patients diagnosed with a psychotic disorder.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02930005
- Testing
- Meclofenamic acid, Pentosan polysulfate sodium
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- The University of Texas Health Science Center, Houston