Clinical trials: Sciatic Neuropathy
Sciatica
Efficacy of Epidural Etanercept in the Treatment of Sciatica
Tumor necrosis factor (TNF)-alpha has been strongly implicated as a major contributing factor for the development of radiculopathy.
- Trial name
- NCT00364572
- Testing
- epidural injection of etanercept
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Piriformis Syndrome
Instrument-Assisted Soft Tissue Mobilization Versus PNF Stretching in Athletes With Piriformis Syndrome
A 12-month randomized controlled trial will be conducted at Pakistan Sports Board, Lahore, with 40 athletes (18-35 years) randomly allocated to IASTM (n=20) or PNF (n=20) groups.
- Trial name
- NCT07090356
- Testing
- Instrument-Assisted Soft Tissue Mobilization, Proprioceptive Neuromuscular Facilitation Stretching
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Low Back Pain, Herniated Lumbar Disk
RELATIONSHIP OF LUMBOPELVIC MUSCULATURE WITH FUNCTIONAL TESTS IN NON-PROFESSIONAL ATHLETES WITH LUMBAR DISC HERNIATION
This is a control-case study. It has been designed to determine if there is a relationship between the cross sectional (thickness), through RUSI ultrasound, of the abdominal muscles, lumbar and hip muscles with the results of the…
- Conditions
- Low Back Pain, Herniated Lumbar Disk, Sciatica
- Trial name
- NCT03880370
- Testing
- Questionnaires / scales, Ultrasound imaging, FLEXIBILITY
- Volunteers
- 60 people
- Sponsor
- Universidad Complutense de Madrid
Diabetic Foot, Diabetic Neuropathies
Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
The purpose of this study was to determine the minimum effective dose of a local anesthetic for proper anesthesia for popliteal sciatic nerve block under ultrasound guidance in patients undergoing surgery for diabetic foot…
- Trial name
- NCT04981067
- Testing
- Maintain the concentration of ropivacaine as same as those used in the previous participant, Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant, Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Piriformis Syndrome
Effectiveness of Instrument Assisted Soft Tissue Mobilization in Management of Piriformis Syndrome
This study aims to assess the effectiveness of IASTM on pain, ROM, Disability and Quality of life among Piriformis Syndrome patients.
- Trial name
- NCT06406023
- Testing
- Conventional treatment, Instrument assisted soft tissue mobilization
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Acute Sciatica, Pain
Comparative Effects of Neural Mobilization and Muscle Energy Technique in Sciatic Patients
In this study, investigator will see the effects of neural mobilization in comparison to the muscle energy technique in the patients suffering from sciatica.
- Trial name
- NCT04875741
- Testing
- Neural mobilization, Muscle energy technique
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Sciatica
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
Sciatica is a condition that causes a sharp, burning pain in the back, buttock, and leg. The condition is caused by injury to or compression of the sciatic nerve, which is located in the back of the leg.
- Trial name
- ACT FAST (NCT00668434)
- Testing
- Prednisone
- Where
- 3 sites in United States
- Volunteers
- 269 people
- Sponsor
- Kaiser Permanente
Sciatica
Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
The purpose of this study is to determine whether anti-inflammatory drugs or glucocorticoids are effective in the treatment of acute sciatica
- Trial name
- TéAGS (NCT01816334)
- Testing
- methylprednisolone, Ketoprofen, Sodium Chloride
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Piriformis Syndrome
"Effects of Facilitated Positional Release Technique( FPRT) Vs. Manual Myofascial Release Technique in Female Patients With Piriformis Syndrome
This study is a randomised control trial and the purpose of this study is to determine the "Effects of Facilitated Postional Release Technique( FPRT) Vs Manual Myofascial Release Technique in Female Patients With Piriformis…
- Trial name
- NCT06753487
- Testing
- Myofacial Release, Facilitated positional release technique
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Foundation University Islamabad
Piriformis Syndrome
Ultrasound-guided vs. Blinded Dry Needling for Piriformis Syndrome
This randomized controlled trial aims to compare the effectiveness of ultrasound-guided versus blinded dry needling for the treatment of piriformis syndrome.
- Trial name
- NCT05882799
- Testing
- Ultrasound-guided dry needling, Blinded dry needling
- Volunteers
- 60 people
- Sponsor
- Uskudar State Hospital
Sciatica
Topiramate in the Treatment of Sciatica
This study will test the effectiveness of topiramate to treat pain caused by lumbar radiculopathy, or sciatica. Sciatica results from damage to the lumbar nerve roots, typically causing back pain and sharp, shooting pain down one…
- Trial name
- NCT00011804
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Sciatica
Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg Pain
This clinical study focuses on people who experience long-term low-back related leg pain (commonly called sciatica). This type of pain is often associated with nerve irritation or compression in the lower spine and can cause…
- Trial name
- NCT07373808
- Testing
- Percutaneous Electrical Nerve Stimulation, Transcutaneous Electrical Nerve Stimulation, Real Dry Needling (without Percutaneous Electrical Nerve Stimulation)
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad Complutense de Madrid
Low Back Pain, Sciatica
Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain
The goal of this quasi-experimental trial was to evaluate the effects of non-surgical spinal decompression on disability and pain in patients with chronic low back pain and sciatica throughout a two-month follow-up, and to…
- Conditions
- Low Back Pain, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06275750
- Testing
- Spinal decompression with BTL-6000 spinal decompression system (BTL Industries Ltd.)
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Hospital Civil de Guadalajara
Radiculopathy, Sciatica
Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)
Double-blind, crossover, randomized, 3x3 Latin square, placebo-controlled study of single intravenous dose administration of VVZ-149. To demonstrate assay sensitivity, lidocaine will be administered as a positive control.
- Trial name
- LMR (NCT02644421)
- Testing
- VVZ-149, Lidocaine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Brigham and Women's Hospital
Piriformis Syndrome, Gluteus Maximus Myofascial Pain
Ultrasound-Guided Interfascial Hydrodissection for Gluteal Myofascial Pain in Piriformis Syndrome: A Prospective Study
This randomized, double-blind prospective trial investigates whether ultrasound-guided interfascial hydrodissection using 10% dextrose is more effective than dry needling in treating gluteal myofascial pain coexisting with…
- Trial name
- NCT07326982
- Testing
- Ultrasound-Guided Interfascial Hydrodissection, Ultrasound-Guided Gluteus Maximus Dry Needling
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Pain, Sciatica
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
The primary objective is to demonstrate the safety and efficacy of a non-awake implantation method (EMG neuromonitoring) of a SCS paddle lead as compared to an awake implantation method (with local anesthesia and patient…
- Conditions
- Chronic Pain, Sciatica, Failed Back Surgery Syndrome
- Trial name
- NAPS (NCT02284542)
- Testing
- Awake, Non-Awake
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Piriformis Syndrome
Sacroiliac Joint Manipulation Effect in Chronic Piriformis Syndrome.
The objective of the study was to determine the effects of sacroiliac joint thrust manipulation on pain, pain pressure threshold, piriformis length and straight leg raise, in chronic piriformis syndrome.
- Trial name
- NCT04603703
- Testing
- HVLAT Manipulation, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Sciatic Neuropathy, Sciatica
Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in Sciatica
Sciatica is not a medical condition itself, but is a symptom of whatever condition is affecting your sciatic nerve. Pain in the lower back, hip and legs is the most common symptom.
- Conditions
- Sciatic Neuropathy, Sciatica, Range of Motion
- Trial name
- NCT06536829
- Testing
- Myofacial release technique and sciatic nerve slider technique, Myofacial release technique
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Piriformis Syndrome
Comparative Presence of Piriformis Syndrome in Patients With Lumbar Disc Bulging and Protrusion
Clinicians consider lumbar disc herniation more prominently in the differential diagnosis than piriformis syndrome, as it is the most common cause of sciatica, and this canalizes them to overlook that the sciatic nerve may be…
- Trial name
- NCT06435169
- Testing
- Lasegue's, Freiberg's and, FAIR (Flexion Adduction Internal Rotation) tests.
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Yuzuncu Yil University
Post Operative Sciatica by Lumbar Spinal Fibrosis
Lumbar Spinal Fibrosis and TNF Alpha Inhibition
TNF-alpha is the main cytokine implicated in the formation of lumbar spinal fibrosis. Inhibiting TNF-alpha could significantly decrease spinal fibrosis after lumbar discectomy.
- Trial name
- NCT00385086
- Testing
- TNF blocker
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris