Clinical trials: Scleritis
Scleritis
Sirolimus Injections for Autoimmune Scleritis
Background: Autoimmune scleritis is an inflammatory disease that affects the white outer part of the eye. It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases.
- Trial name
- ISAS (NCT01517074)
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Uveitis, Cancer
Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study
This study will evaluate whether therapy that suppresses the immune system given to treat inflammatory diseases of the eye is associated with a greater risk of death and of cancer.
- Conditions
- Uveitis, Cancer, Infection, Mortality
- Trial name
- NCT00116090
- Where
- 4 sites in United States
- Volunteers
- 6,300 people
- Sponsor
- National Eye Institute (NEI)
Scleritis and Episcleritis
Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis
The main purpose of this study is to describe the optical coherence tomography (OCT) findings in eyes with scleral inflammation and to differentiate cases with anterior scleritis from those with episcleritis and normal controls.
- Trial name
- NCT01958567
- Testing
- Optical Coherence Tomography
- Where
- Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Scleritis
Study Evaluating PSI-697 in Patients With Scleritis
To evaluate the safety of an orally administered single dose of PSI-697 in subjects with scleritis, as a model of inflammatory disease.
- Trial name
- NCT00367692
- Testing
- PSI-697
- Volunteers
- 12 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Uveitis, Scleritis and Episcleritis
Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore
This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).
- Conditions
- Uveitis, Scleritis and Episcleritis, Endophthalmitis, Masquerade Syndromes
- Trial name
- NCT07176130
- Testing
- No Intervention: Observational Cohort
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Singapore National Eye Centre
Scleritis, Orbital Disease
Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation
The purpose of this study is to assess the safety and tolerability of Rituximab in refractory scleritis and non-infectious orbital inflammation.
- Trial name
- NCT00415506
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Necrotizing Scleritis
Perichondrium Autograft in Refractory Necrotizing Scleritis
Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis. The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in…
- Trial name
- PCRNS (NCT02864823)
- Testing
- Perichondrium Autografts
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Chung-Ang University Hospital
Uveitis, Anterior Uveitis
Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients
Uveitis represents a heterogeneous group of diseases that results from ocular inflammatory reaction involving ocular tissue and vasculature. The inflammation usually causes pain, redness, photophobia and blurred vision.
- Conditions
- Uveitis, Anterior Uveitis, Intermediate Uveitis, Posterior Uveitis
- Trial name
- NCT02764697
- Testing
- H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Tampa Bay Uveitis Center, LLC
Uveitis, Scleritis
Human Samples and Data Repository
This protocol will enable IRB (institutional review board) review of proposed research using human samples and data collected under the terminated NIH studies 04-EI-0065 and 96-EI-0096.
- Trial name
- NCT00539370
- Where
- United States
- Volunteers
- 1,862 people
- Sponsor
- National Eye Institute (NEI)
Scleritis
Gevokizumab for Active Scleritis
Background: Scleritis is the inflammation of the white outer coating of the eye, known as the sclera. In severe cases, it can cause blindness. It is commonly associated with autoimmune disorders such as rheumatoid arthritis.
- Trial name
- NCT01835132
- Testing
- Gevokizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Eye Institute (NEI)
GPA, Vasculitis
Ocular Manifestations of Granulomatosis With Polyangiitis.
The current state of knowledge on ANCA-associated vasculitis (AAV) indicates that it is a group of autoimmune diseases in which small blood vessels in various organs are affected.
- Conditions
- GPA, Vasculitis, Microscopic Polyangiitis (MPA), Churg-Strauss Syndrome (CSS)
- Trial name
- NCT07664709
- Testing
- Optical coherence tomography angiography
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Military Institute od Medicine National Research Institute
Scleritis
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis
ATLAS study is a clinical trial to evaluate the potential role of subcutaneous adrenocorticotropic hormone (ACTH) gel in the management of non-infectious scleritis.
- Trial name
- ATLAS (NCT03465111)
- Testing
- ACTH (adrenocorticotropic hormone) gel
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Metropolitan Eye Research & Surgery Institute
Uveitis, Scleritis
Causes of Visual Loss in Retinal Disease
This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.
- Trial name
- NCT01613963
- Testing
- Immunosuppressive Agents
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Hereditary Autoinflammatory Diseases, Schnitzler Syndrome
AutoInflammatory Disease Alliance Registry (AIDA)
Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system.
- Conditions
- Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome
- Trial name
- AIDA (NCT05200715)
- Testing
- No intervention is foreseen by the protocol.
- Where
- 112 sites in Algeria, Australia and 20 more
- Volunteers
- 3,500 people
- Sponsor
- University of Siena
Idiopathic Refractory Scleritis
Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)
This study will evaluate the Efficacy and Safety of Infliximab versus Cyclophosphamide in Subjects with Idiopathic Refractory Scleritis.
- Trial name
- CIRIS (NCT03088293)
- Testing
- Infliximab, Cyclophosphamide
- Sponsor
- Hospices Civils de Lyon
Non-infectious, Non-necrotizing Anterior Scleritis
Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study
This is an initial clinical trial evaluating whether different doses of iontophoresis for delivery of dexamethasone phosphate can be tolerated by eyes of patients with non-infections, non-necrotizing scleritis.
- Trial name
- NCT01059955
- Testing
- Dexamethasone Phosphate Ophthalmic Solution (EGP-437), Dexamethasone phosphate ophthalmic solution
- Where
- 6 sites in United States
- Volunteers
- 18 people
- Sponsor
- John Kempen
Scleritis
Infliximab to Treat Non-Infectious Scleritis
This small, preliminary study will examine whether multiple infusions of infliximab (Remicade® (Registered Trademark)) can control inflammation in patients with active scleritis.
- Trial name
- NCT00075075
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Uveitis, Scleritis
Tofacitinib for Inflammatory Eye Disease
Non-infectious inflammatory eye disease, such as uveitis and scleritis, is a chronic, auto-immune process that leads to vision loss.
- Trial name
- NCT03580343
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Uveitis, Conjunctivitis
Ocular Manifestations in Rheumatic Diseases
This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.
- Conditions
- Uveitis, Conjunctivitis, Keratoconjunctivitis Sicca, Xerophthalmia
- Trial name
- NCT03753893
- Testing
- No intervention used
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's