Clinical trials: Sclerosis, Multiple
Multiple Sclerosis
Evaluating Intervention Responsiveness in People With Multiple Sclerosis
The purpose is to see how multiple sclerosis (MS) is associated with strength and sensation using MRI, in persons with MS. The investigators will also see whether exercise can improve these symptoms for persons with MS.
- Trial name
- NCT01632293
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Healthy
Tolerability and Bioavailability of the P144 Peptide Inhibitor of TGF-β1 After Topical Administration in Healthy Volunteers
Transforming growth factor-beta 1 (TGF-β1) is consistently over expressed in most fibrotic diseases and displays a variety of profibrotic effects in fibroblasts.
- Trial name
- NCT00656825
- Testing
- P144 cream
- Where
- 2 sites in Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- ISDIN
Multiple Sclerosis
Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease.
- Trial name
- ITEMS (NCT02518776)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
A Bioequivalence Study of Serum Free Avonex and Serum Containing Avonex in Healthy Volunteers
Demonstrate the bioequivalence of a serum-free solution to a serum containing solution of Avonex.
- Trial name
- NCT00913250
- Testing
- Serum containing Avonex, Serum Free Avonex
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Biogen
Multiple Sclerosis
Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers
The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue.
- Trial name
- COMMITMENT (NCT05561621)
- Testing
- Voice analysis
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis
Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS
Imaginative Distention (ID) is proposed as supportive and integrative intervention to cope with fatigue, (principal end point), to cope with insomnia, stress perception and to improve QoL of pw MS, insomnia pw and health care…
- Trial name
- DIMMISI (NCT02290990)
- Testing
- "Imaginative Distention" technique
- Where
- Italy
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Multiple Sclerosis
Cerebral Blood Flow and tDCS
With this study, the investigators will substantiate if regional cerebral blood flow (CBF) is affected by tDCS, assess the amount of CBF change in relation to different currents, and measure differences in regional CBF under…
- Trial name
- NCT04033133
- Testing
- tDCS
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Multiple Sclerosis, NMO Spectrum Disorder
A Study of LP-168 in Healthy Volunteers
This is a Phase I study designed to assess the safety, tolerability and pharmacokinetics of LP-168 in healthy human volunteers.
- Trial name
- NCT05432713
- Testing
- LP-168 tablet
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Guangzhou Lupeng Pharmaceutical Company LTD.
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Healthy Volunteers
Safety Study of GNbAC1 Monoclonal Antibody in Healthy Male Volunteers
In this clinical study, the safety and tolerability of GNbAC1 as a treatment for MS patients will be evaluated in healthy male volunteers.
- Trial name
- NCT02452996
- Testing
- GNbAC1
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GeNeuro Innovation SAS
Multiple Sclerosis, Neuromyelitis Optica
Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct
The purpose of this study is to determine the ability of STRATUS OCT and high resolution OCT to detect and to quantify the neural loss in multiple sclerosis and neuromyelitis optica and its subtypes.
- Trial name
- NCT01024985
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pediatric Multiple Sclerosis
Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis
Most youth with MS experience symptoms such as depression and fatigue. In addition, cognitive issues, especially with attention and memory occur frequently.
- Trial name
- NCT03067025
- Testing
- Actigraphy
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis
A Multi-Site Trial of MS INFoRm (Fatigue Management Resource)
People with MS commonly experience extreme fatigue that negatively impacts their ability to engage in a full range of daily activities, quality of life, and employment.
- Trial name
- NCT03362541
- Testing
- MS INFoRm, Usual Care Control Group
- Where
- 3 sites in Canada
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Dr. Marcia Finlayson
Multiple Sclerosis
Pelvic Floor Disorders in Multiple Sclerosis Patients
Primary objective 1. Clinical assessment of bowel, bladder, and sexual dysfunction in patients with MS 2. Impact of sphincter disorders on quality of life in patients with MS by using correlation between Extended Disability…
- Trial name
- NCT06473753
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
The Gut Microbiome in Adult Multiple Sclerosis
This study aims to assess the following research questions: 1. Map and benchmark the gut microbiome of patients with RRMS, and PPMS versus matched healthy controls 2.
- Trial name
- MICROMS5Y (NCT04929145)
- Where
- 2 sites in Belgium
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National MS Center Melsbroek
Alzheimer Disease, Mild Cognitive Impairment
Longitudinal Cognitive Assessment by BoCA
The Boston Cognitive Assessment (BoCA) is a self-administered online test intended for longitudinal cognitive monitoring. BoCA uses random not-repeating tasks to minimize learning effects.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia, Frontotemporal Dementia
- Trial name
- BoCA (NCT04114994)
- Testing
- Boston Cognitive Assessment (BoCA)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Light LLC
Multiple Sclerosis
COld Exposure With Controlled BReathing And Meditation in Patients With Multiple Sclerosis (COBRAMS)
The goal of this interventional study is to test the effect of the anti-inflammatory and neuroprotective effects of this supplementary training program that includes breathing exercises, cold exposure, and meditation in patients…
- Trial name
- COBRAMS (NCT06280573)
- Testing
- Wim Hoff method
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Comenius University
Multiple Sclerosis
Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis
The investigators principal hypothesis is that INO and optic neuritis are objective, quantitative, and reproducible models for corroborating the hypothesis that changes in core body temperature are associated with the reversible…
- Trial name
- NCT00854750
- Testing
- ACTHAR
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Elliot Frohman