Clinical trials: Scoring Systems
Parkinson's Disease, Motor Symptoms
Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)
This study is designed to assess the effect of APOKYN treatment in rapid and reliable improvement of motor symptoms in Parkinson's disease (PD) subjects suffering from delayed or unreliable onset of levodopa (L-dopa) action.
- Conditions
- Parkinson's Disease, Motor Symptoms, Akinesia, Hypomobility
- Trial name
- AM IMPAKT (NCT01770145)
- Testing
- APOKYN, L-dopa, Trimethobenzamide
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Esophageal Cancer, Chemoradiotherapy
A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer
This phase II clinical study is designed to evaluate the 1 year local tumor control rates after the targeted therapy of intensity-modulated radiation therapy synchronized chemotherapy with nimotuzumab combined with S-1 in local…
- Conditions
- Esophageal Cancer, Chemoradiotherapy, Nimotuzumab, Unresectable Malignant Neoplasm
- Trial name
- NCT04207918
- Testing
- Radiotherapy, Nimotuzumab, S-1
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Abdominal Pain, Chest Pain
Anchoring Patients Pain Scores in the Emergency Department
The proposed research will be a prospective, observational study to test the hypothesis that anchoring will affect verbal pain scores in the emergency department.
- Conditions
- Abdominal Pain, Chest Pain, Headache, Joint Pain
- Trial name
- NCT04717518
- Testing
- Measurement of Pain
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Rectal Cancer, Anastomotic Leak
Does the Management of Anastomotic Leakage After Low Rectal Resection Affect Survival
The aim of this retrospective cohort-study is to assess the effects of AL and its severity divided according the ISREC-classification on the long-term oncological outcome.
- Trial name
- ISRECLeak (NCT06059924)
- Testing
- Anastomotic leakage
- Where
- Switzerland
- Volunteers
- 941 people
- Sponsor
- Cantonal Hospital of St. Gallen
Intracerebral Hemorrhage
Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control
Intracerebral hemorrhage (ICH) is the second most common form of stroke, with an incidence of around 3000 cases per year in Hong Kong.
- Trial name
- TRIACT (NCT07458880)
- Testing
- Exforge HCT® or Three Individual drug amlodipine + valsartan + hydrochlorothiazide
- Where
- 4 sites in Hong Kong
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Neuroendocrine Tumors, Surgery
Prophylactic Cholecystectomy is Not Mandatory in Patients Candidate to the Resection for Small Intestine Neuroendocrine Neoplasms: a Propensity Score-matched and Cost-minimization Analysis
To evaluate two competitive strategies in patients undergoing resection of Small-intestine Neuroendocrine neoplasms (Si-NEN): Prophylactic Cholecystectomy (PC) versus On-demand delayed cholecystectomy
- Conditions
- Neuroendocrine Tumors, Surgery, Gut Tumor
- Trial name
- NCT04780737
- Testing
- Cholecystectomy
- Volunteers
- 230 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Pancreatitis
The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score
The investigators to establish whether early microvascular permeability parameter evaluated by perfusion-CT could be good biomarkers for severity in acute pancreatitis.
- Trial name
- K-PA (NCT03456557)
- Testing
- Perfusion computed tomography.
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Low Anterior Resection Syndrome
Translation of the International Consensus Definition of LARS Into a Bowl Dysfunction Severity Scoring Tool (New LARS Score)
The purpose of this study is to develop a new severity scoring tool for Low Anterior Resection Syndrome (LARS) drawing on the international consensus criteria for LARS as well as opinions of patients with lived-experience of LARS.
- Trial name
- NCT05605600
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Cardiff and Vale University Health Board
Ovarian Tumor
EURAD-MR Classification : European Multicenter Study
An adnexal mass is the most common indication for gynaecological surgery . Pre operative characterization is crucial and a scoring system would be useful to standardize the imaging report and thus, improve patient management.
- Trial name
- EURAD (NCT01738789)
- Where
- 24 sites in Austria, Croatia and 6 more
- Volunteers
- 1,340 people
- Sponsor
- Société d'Imagerie de la Femme
Prostate Cancer
A Diagnostic Prediction Model for Prostate Cancer in Patients With PI-RADS Score 3
The goal of this observational study is to construct a predictive model for improving the diagnostic accuracy in patients with PI-RADS score of 3.
- Trial name
- NCT06507462
- Testing
- prostate biopsy
- Where
- 3 sites in China
- Volunteers
- 460 people
- Sponsor
- Anhui Provincial Hospital
COVID
Predicting Death and ICU Admission in COVID-19 Patients in ED
INTRODUCTION. The novel coronavirus designated SARS-CoV-2, has determined an international outbreak of respiratory illness named Covid-19. Patients with Covid-19 present primarily with fever, myalgia or fatigue, and dry cough.
- Trial name
- NCT04371562
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myelodysplastic Syndrome
A Study Comparing Siltuximab Plus Best Supportive Care to Placebo Plus Best Supportive Care in Anemic Patients With International Prognostic Scoring System Low- or Intermediate-1-Risk Myelodysplastic Syndrome
The purpose of this study is to evaluate the efficacy of siltuximab, demonstrated by a reduction in red blood cell (RBC), transfusions to treat the anemia of Myelodysplastic Syndrome (MDS).
- Trial name
- NCT01513317
- Testing
- Siltuximab, Best supportive care (BSC)
- Where
- 23 sites in United States, Australia and 5 more
- Volunteers
- 76 people
- Sponsor
- Janssen Research & Development, LLC
Allergic Rhinitis (w/w Asthma) Due to Alternaria Alternata
Sublingual Immunotherapy In Alternaria-Induced Rhinitis
Respiratory allergy due to Alternaria is a relevant clinical problem, and specific immunotherapy may represent a viable treatment option. Sublingual immunotherapy (SLIT) is safe and effective, but data for Alternaria are lacking.
- Trial name
- NCT01127035
- Testing
- sublingual immunotherapy
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- University of Genova
Renal Cell Carcinoma
Multimodal Recurrence Scoring System for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment
Whether patients with stage III clear cell renal cell carcinoma (ccRCC) should receive adjuvant targeted therapy or not is still on debate.
- Trial name
- NCT06032728
- Testing
- Sunitinib
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Spinal Cord Injury (SCI)
Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
Acute Spinal Cord Injury (SCI) is a rare injury that leads to permanent neuromotor impairment and sudden disability. Approximately 25,000 people experience cervical SCI in the United States, Europe, and Japan every year.
- Trial name
- ELASCI (NCT04295538)
- Testing
- Elezanumab
- Where
- 41 sites in United States, Australia and 5 more
- Volunteers
- 60 people
- Sponsor
- AbbVie
GastroIntestinal Bleeding
Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion.
- Trial name
- NCT04662918
- Where
- 23 sites in United States, Brazil and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Xingshun Qi
Analgesia
Dexmedetomidine for Pain Reduction in CABG
The purpose of this study is to determine whether adjuvant intravenous dexmedetomidine infusion starting after induction of general anesthesia can provide superior pain management (decrease pain scores) and decrease opioid…
- Trial name
- NCT05534230
- Testing
- Dexmedetomidine Injectable Solution, Saline
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Graft-versus-host Disease
Neihulizumab for Standard-Risk Acute Graft Versus Host Disease (GVHD)
This is a single-center Phase I study to determine the maximum tolerated dose and safety of Neihulizumab for the treatment of Minnesota standard-risk aGVHD.
- Trial name
- NCT04144036
- Testing
- Neihulizumab, 3 mg/kg, Neihulizumab, 6 mg/kg, Neihulizumab, 9 mg/kg
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sameem M. Abedin, MD
Non-small Cell Lung Cancer
Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases
This clinical trial is aimed at the evaluation of the safety and clinical activity of tiragolumab in combination with atezolizumab with or without chemotherapy in the first line treatment of metastatic non-squamous NSCLC patients…
- Trial name
- NCT05746481
- Testing
- Tiragolumab, Atezolizumab, Pemetrexed
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Liza Villaruz, MD
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