Clinical trials: Scotoma
Age-related Macular Degeneration
Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV)
A device has been developed that has eye trackers integrated within the Head Mounted Display (HMD) and can remap text and images around the scotoma in real time to prevent information loss from a central scotoma.
- Trial name
- HETALCEV (NCT02829606)
- Testing
- small scotoma using Head Mounted Display No re-mapping, Large scotoma using Head Mounted Display PLUS re-mapping
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Age-related Macular Degeneration
Visual Remapping to Aid Reading With Field Loss
Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.
- Trial name
- NCT03848663
- Testing
- Traditional Remapping, Personalized Remapping
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Macular Polypoidal Choroidal Vasculopathy (PCV)
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor…
- Trial name
- PROUD (NCT05666804)
- Testing
- Brolucizumab 6mg
- Where
- 15 sites in South Korea
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
Hemianopia, Quadrantanopia
The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy
The purpose of our study is to explore the efficacy of combination of brain stimulation with visual rehabilitation in patients with visual field loss resulting from brain lesions.
- Conditions
- Hemianopia, Quadrantanopia, Scotoma, Visual Field Loss
- Trial name
- NCT00921427
- Testing
- Vision Restoration Therapy (VRT), Transcranial direct current stimulation (tDCS)
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Macular Degeneration, Central Visual Impairment
Scotoma Perimetry Oculomotor Training
The proposed research is relevant to public health because a greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has potential to benefit millions of individuals…
- Trial name
- SPOT (NCT05456581)
- Testing
- 'Scotoma awareness' Training, Control Training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
Complete Hemianopia, Incomplete Hemianopia
Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions
Visual field areas, which are not absolutely blind, are hypothesized to have some residual capacities that constitute their potential for vision restoration.
- Conditions
- Complete Hemianopia, Incomplete Hemianopia, Scotoma, Quadrantanopia
- Trial name
- NCT01418820
- Testing
- Verum stimulation
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Magdeburg
Symptomatic Vitreomacular Adhesion
A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion
The purpose of this study is to evaluate the superiority regarding vitreomacular adhesion (VMA) resolution of a single intravitreal injection of A01016 (Ocriplasmin) compared to sham-injection in subjects with symptomatic VMA.
- Trial name
- NCT01889251
- Testing
- Ocriplasmin
- Where
- Japan
- Volunteers
- 251 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma (POAG)
Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients
The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.
- Trial name
- TRASCO (NCT00902109)
- Testing
- Perimetry, Confocal Scanning Laser Tomography, Optical Coherence Tomography (OCT)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Tuebingen
Diabetic Macular Oedema, Parafoveal Scotoma
Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema
Diabetic macular oedema (DMO) is a sight-threatening problem for diabetic patient who has swelling in macula. Patients with DMO can receive laser treatment and achieve good acuity finally.
- Trial name
- NCT02457884
- Testing
- Temporal Group, Spatial Group, Combined Group
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Hong Kong Polytechnic University
Central Visual Impairment, Macular Degeneration
Factors in Learning And Plasticity: Healthy Vision
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision.
- Trial name
- FLAP (NCT05439759)
- Testing
- Condition 1: Training visual sensitivity, Condition 2: Training spatial integration, Condition 3: Training spatial attention
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Macular Degeneration
Scotoma Reduction in AMD Patients Treated With Ranibizumab
This is a trial aimed at patients with advanced wet macular degeneration and macular scarring treated wiht intravitreal injections of Lucentis.
- Trial name
- SALVAGE (NCT00467935)
- Testing
- intravitreal injection Lucentis (ranibizumab)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Retina Research Foundation
Scotoma
Smartphone Flicker Fusion Test for Patients With Optic Disorders.
The purpose of this project is to validate a quick, easy-to-use and administer smartphone flicker fusion test. The app (called eyeFusion) can potentially be used to easily and quickly collect critical flicker fusion measurements…
- Trial name
- NCT03475147
- Testing
- eyeFusion
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Glaucoma
Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter
The purpose of this study is to compare three perimetric techniques regarding progression of the visual field.
- Trial name
- X-SCOPE (NCT01068938)
- Testing
- three different perimeters: HFA, Octopus, MATRIX
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Visual Field Defect, Peripheral, Visual Field Defect, Nasal Step
Patient Performance and Acceptance of Virtual Reality Visual Field Devices
The purpose of this research is to study the effectiveness and patient experience when measuring visual fields using virtual reality goggles.
- Conditions
- Visual Field Defect, Peripheral, Visual Field Defect, Nasal Step, Visual Field Defect, Paracentral Scotoma of Both Eyes
- Trial name
- NCT04786886
- Testing
- VIrtual Reality Visual Field Exam
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Miami
Scotoma, Central, Central Visual Impairment
Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas
The research is aimed at developing and testing a new method of visual-motor rehabilitation of Veterans with macular degeneration by using inexpensive "tablet" computers at home.
- Trial name
- VRT (NCT01691027)
- Testing
- Visuo-motor training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Healthy
tFUS Induced Transient Scotoma for Individual Dosing
The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured. 2.
- Trial name
- NCT06426498
- Testing
- Brainsonix Bx Pulsar machine tFUS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Central Visual Impairment, Macular Degeneration
Factors in Learning And Plasticity: Macular Degeneration
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision.
- Trial name
- FLAP (NCT05454124)
- Testing
- Training visual sensitivity, Combination training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Age Related Macular Degeneration
Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy
The rationale for evaluating LucentisTM (a recombinant humanized anti-human Vascular Endothelial Growth Factor (VEGF) monoclonal antibody (Fab) in patients with neovascular (wet) Age related Macular Degeneration (AMD) is based on…
- Trial name
- FVF4193s (NCT01255774)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The New York Eye & Ear Infirmary
Upper Gastrointestinal Symptoms
Effect of AI Monitoring Blind Spots of EGD on the Inspection Time and Lesion Dection Rate
The goal of this clinic trial is to learn about the effect of AI monitoring blind spots on the inspection time to EGD. Patients are randomly assigned to undergo an EGD with or without the assistance of AI.
- Trial name
- NCT05832411
- Testing
- Endoangle
- Volunteers
- 1,672 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Age-Related Macular Degeneration, Geographic Atrophy
Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients With Geographic Atrophy Study
This study is a biomarker evaluation study in patients with geographic atrophy secondary to age-related macular degeneration (AMD).
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Visual Field Defect, Central Scotoma of Both Eyes
- Trial name
- OMEGA (NCT05963646)
- Testing
- Natural history study
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Institute of Molecular and Clinical Ophthalmology Basel