Clinical trials: Seasonal Human Influenza, active
Influenza, Human
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age
This study will compare an investigational mRNA flu vaccine with a licensed flu vaccine in adults 65 years of age and older. Participants will receive one injection and will be followed during the flu season.
- Trial name
- NCT07805707
- Testing
- mRNA Seasonal Flu vaccine, Licensed Influenza Vaccine
- Where
- 163 sites in United States
- Volunteers
- 54,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Seasonal Influenza
A Study of Updated mRNA Seasonal Influenza Vaccines
The purpose of this study is to evaluate the immunogenicity and safety of updated strain-containing compositions of the mRNA-1010 vaccines within the current epidemiological environment.
- Trial name
- NCT07884175
- Testing
- mRNA-1010, Licensed High-Dose Seasonal Influenza Vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Behavior Change Interventions
Acceptability, Usability and Preliminary Effectiveness of ChatGPT in Increasing Seasonal Influenza Vaccination Uptake Among Older Adults in Hong Kong
In this project, we will train a ChatGPT to provide real-time answers to questions related to the SIV for older adults in Hong Kong.
- Trial name
- NCT06679647
- Testing
- Access to a trained ChatGPT
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Influenza Prevention, Seasonal Influenza
Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults
Background: Vaccines help the body learn to fight infections. Some vaccines are combined with adjuvants, which are added substances that make vaccines work better.
- Trial name
- NCT06863142
- Testing
- VRC-FLUMOS0116-00-VP, ALFQ
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore
The goal of this clinical trial is to learn if the high-dose influenza vaccine can improve year-round protection in older adults aged 60 years and above.
- Trial name
- SingVax-01 (NCT07883421)
- Testing
- High-dose influenza vaccine, Standard-dose influenza vaccine
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Influenza
Phase 1/2 Study of a Plant-Based Seasonal Recombinant Trivalent VLP Influenza Vaccine
This Phase 1/2 study is intended to assess the safety, tolerability, and immunogenicity of recombinant TVLP in adults 18-64 and 65 years of age and above and to confirm the dose(s) to be developed further in these two age cohorts.
- Trial name
- NCT07291635
- Testing
- Recombinant Influenza vaccine candidate, Commercial Influenza vaccine
- Where
- 7 sites in Canada
- Volunteers
- 728 people, healthy volunteers welcome
- Sponsor
- Aramis Biotechnologies Inc.
Acute Coronary Syndrome, Heart Failure
Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)
The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Heart Failure, Influenza, Human, Cardiovascular Diseases
- Trial name
- VACC-UP (NCT07721649)
- Testing
- Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination
- Where
- 2 sites in Germany
- Volunteers
- 482 people
- Sponsor
- Stephan Baldus
Seasonal Influenza
Phase I Clinical Trial of Trivalent Inactivated Split Influenza Virus Vaccine (MDCK Cell)
This study is a phase I, randomized, double-blind, placebo and active comparator-controlled clinical trial to evaluate the safety and immunogenicity of a trivalent split influenza virus vaccine (MDCK cell) developed by Sinovac…
- Trial name
- NCT07889193
- Testing
- Cell-based Trivalent Split Influenza Virus Vaccine (cTIV), Egg-based Trivalent Split Influenza Virus Vaccine (eTIV)
- Where
- China
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Influenza, Human+COVID-19
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
This early-stage study will look at a new mRNA vaccine that combines defenses against both seasonal flu and COVID-19 in terms of its safety and how it builds protection.
- Trial name
- NCT07464314
- Testing
- Investigational mRNA Seasonal Flu/COVID-19 Combination (Flu/COVm) Vaccine, Licensed Seasonal Influenza Vaccine, Licensed COVID-19 Vaccine
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- GlaxoSmithKline
Influenza, Human
A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age
This clinical trial will study an investigational seasonal influenza vaccine in adults 18 to 64 years of age. The vaccine is based on messenger ribonucleic acid, also called mRNA.
- Trial name
- NCT07851246
- Testing
- mRNA Seasonal Flu vaccine, Comparator 1, Comparator 2
- Where
- 12 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza
B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults
This study will examine how various FDA-approved seasonal influenza vaccine types, used in a manner consistent with their approved use, impact the characteristics of influenza specific antibodies in humans, and how these…
- Trial name
- NCT04101838
- Testing
- Fluzone, Flucelvax, Fluzone High-Dose
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Behavior Change
Chatbot-delivered Theory-based Online Intervention in Increasing Seasonal Influenza Vaccination Uptake Among Children Aged 3-6 Years
This randomized controlled trial will compare the efficacy of a Chatbot-delivered stage-of-change-tailored online intervention versus a Chatbot-delivered non-stage-of-change-tailored online intervention for mothers in increasing…
- Trial name
- NCT07687719
- Testing
- Stage-of-change-tailored intervention, Non-stage-of-change-tailored intervention
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC)
A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision
This study is investigating the effects on immune cells of injecting the influenza vaccine (also known as "flu shot") into cutaneous squamous cell carcinoma (CSCC) tumors prior to having standard-of-care Mohs excision surgery.
- Conditions
- Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC), Cutaneous Squamous Cell Cancer
- Trial name
- NCT06664151
- Testing
- Fluzone Trivalent
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Dana-Farber Cancer Institute
Pneumococcal Disease
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 With Influenza Vaccine in Adults ≥ 50 Years of Age
This is a Phase 3, randomized, double-blind study to evaluate the safety and immunogenicity of VAX-31 and seasonal influenza vaccine in pneumococcal-naïve adults ≥ 50 years when the two vaccines are administered at the same visit…
- Trial name
- NCT07365826
- Testing
- 31-valent pneumococcal conjugate vaccine, Seasonal Influenza Vaccine (SIV) (Flublok)
- Where
- 25 sites in United States
- Volunteers
- 1,390 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Upper Resp Tract Infection
Climate Change Trends and Their Impact on the Seasonal Upper Respiratory Tract Disease Burden
Investigators assume that global climate changes can influence upper respiratory tract infection peak prevalence, which may have significant clinical implication, for example, by adjusting seasonal Influenzas' vaccine timing.
- Trial name
- NCT07767019
- Testing
- No Intervention: Observational Cohort
- Where
- Israel
- Volunteers
- 5,000 people
- Sponsor
- Barzilai Medical Center
Seasonal Influenza
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Children
The purpose of this study is to evaluate safety, reactogenicity, and immunogenicity of mRNA-1010 in healthy children (9 to <18 years of age).
- Trial name
- NCT07870330
- Testing
- mRNA-1010, Fluarix Trivalent
- Where
- 6 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.