Clinical trials: Second Cancer
Cystic Cavity Area Reduction Efficiency, the Recurrence of the Tumor
Clinical Evaluation of Fenestration Decompression Combined With Secondary Curettage for Ameloblastoma of the Jaw: Retrospective Radiographic Analysis
Objectives: To investigate the outcomes of fenestration decompression combined with secondary curettage (FDSC) in the surgical treatment of jaw ameloblastoma.
- Trial name
- NCT04987515
- Testing
- fenestration decompression combined with secondary curettage
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Hepatocellular Carcinoma
Role of CEUS as a Secondary Diagnostic Modality
To determine the role of contrast-enhanced ultrasound (CEUS) as a second-line imaging modality after gadoxetate-enhanced MRI (Gd-EOB-MRI) for identifying hepatocellular carcinoma (HCC) among at-risks observations.
- Trial name
- NCT04494022
- Testing
- contrast enhanced ultrasound
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neoplasms
A Study of Irinotecan With Dabrafenib Plus Trametinib and Anti-EGFR in the Second Line of Therapy in People With Metastatic Colorectal Cancer
The purpose of this study is to evaluate the efficacy and toxicity of irinotecan with dabrafenib, cetuximab/panitumumab in the second line of treatment for the potential treatment of colorectal cancer that: has a metastatic…
- Trial name
- NCT06967155
- Testing
- • Drug: Dabrafenib • Drug: Trametinib • Drug: Cetuximab • Drug: Рanitumumab • Drug: Oxaliplatin • Drug: Irinotecan • Drug: Leucovorin • Drug: 5-FU
- Where
- Russia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Blokhin's Russian Cancer Research Center
Myelodysplastic Syndrome, Secondary Acute Myeloid Leukemia
Plasmatic L-AScorbic Acid in MYelodyplastic Syndroms and Controls
Myelodysplastic syndromes (MDS) is a group of heterogeneous diseases characterised by the clonal evolution of dysplastic hematopoietic stem cells.
- Trial name
- PLASMYC (NCT02809222)
- Testing
- Samples, Quality of life questionnaire
- Where
- 2 sites in France
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Leukemia, Myelodysplastic Syndromes
Evaluating Cell Damage in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Fanconi Anemia; in Patients Who Were Exposed to Alkylating Agents; and in Healthy Volunteers
RATIONALE: Studying samples of bone marrow from patients with cancer and from healthy volunteers in the laboratory may help doctors learn more about changes that occur in bone marrow stromal (connective tissue) cells.
- Trial name
- NCT00899795
- Testing
- cytogenetic analysis, fluorescence in situ hybridization, flow cytometry
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Birth Injuries
The Effect of Primary Delivery of the Anterior Compared With the Posterior Shoulder on Perineal Trauma: a Randomized Controlled Trial
It is unknown if primary delivery of the anterior or the posterior shoulder causes less perineal tear. The objective of this trial is to evaluate the incidence and degree of perineal trauma after primary delivery of the anterior…
- Trial name
- NCT01937546
- Testing
- Primary delivery of anterior shoulder, Primary delivery posterior shoulder
- Where
- Denmark
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Artificial Intelligence, Deep Learning
Artificial Intelligence System for Assessment of Tumor Risk and Diagnosis and Treatment
To improve the accuracy of risk prediction, screening and treatment outcome of cancer, we aim to establish a medical database that includes standardized and structured clinical diagnosis and treatment information, image features…
- Conditions
- Artificial Intelligence, Deep Learning, Lung Cancer, Lung; Node
- Trial name
- NCT05426135
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lymphedema, Secondary
Skin Biophysical Measures for Assessing Head and Neck Cancer-Related External Lymphedema
Selected measurements in healthy persons of skin tissue dielectric constant as reference values for subsequent use to evaluate patients with head and neck lymphedema.
- Trial name
- NCT04457375
- Testing
- TDC
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Breast Cancer
Alopecia Secondary to Endocrine Therapy in Postmenopausal Women With Breast Cancer
This is a study to determine the prevalence and severity of alopecia (hair loss) experienced by postmenopausal breast cancer patients receiving endocrine therapy including Tamoxifen, Letrozole (Femara), Exemestane (Aromasin), or…
- Trial name
- NCT01300871
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer, Cognitive/Functional Effects
Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and in Healthy Volunteers
RATIONALE: Gathering information over time from women undergoing chemotherapy for breast cancer may help doctors learn more about mental and physical fatigue caused by treatment.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults
- Trial name
- NCT00909662
- Testing
- assessment of therapy complications, cognitive assessment, fatigue assessment and management
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer Female
Evaluation of the Potential Impact of an Artificial Intelligence Solution in Second Reading of Organized Screening.
Based on data from a series of patients who underwent screening mammography with a "normal" or "benign" first-reading result. The main objective of the study is to evaluate the possibilities of subtracting from the second reading…
- Trial name
- ELIAS (NCT06479772)
- Where
- France
- Volunteers
- 55,589 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Lung Cancer (NSCLC)
Snakehead Fish Extract and Curcumin Co-Supplementation in Advanced Lung Cancer on Inflammation, Nutritional Status, and Quality of Life
Background: Patients with advanced lung cancer receiving systemic therapy often experience nutritional decline, systemic inflammation, and impaired quality of life.
- Trial name
- BMI (NCT07906626)
- Testing
- Snakehead Fish Extract and Curcumin
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Allogeneic Stem Cell Transplantation
Allo After Allo Stem Cell Transplantation Following Relapse After Allogeneic Transplant in Haematological Malignancies: Retrospective Results of the GETH
The allogeneic hematopoietic stem cell marrow is the only curative treatment for many hematologic malignancies. However, many patients relapse in these situations to be therapeutic possibilities scarce and mixed.
- Trial name
- NCT01212796
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Grupo Espanol de trasplantes hematopoyeticos y terapia celular
Colorectal Cancer
Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
The burden of colorectal cancer (CRC) is unequal among various populations within the United States. This inequality is most notable among African Americans, who exhibit the highest CRC mortality of all US populations.
- Trial name
- NCT03640208
- Testing
- Education presented by trained caregiver
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Genes and Other Risk Factors for Second Primary Breast Cancer in Women With Breast Cancer and Their Female Family Members and Friends
RATIONALE: Studying samples of blood, urine, and tumor tissue in the laboratory from patients with cancer and their female relatives and friends may help doctors learn more about changes that occur in DNA and identify biomarkers…
- Trial name
- NCT00896818
- Testing
- DNA analysis, genetic linkage analysis, loss of heterozygosity analysis
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cancer Research UK
Tumor Genomic Profiling
Cancer Patients Decision Making and Family Communication About Secondary Findings From Tumor Genomic Profiling
The objective of this protocol is to characterize cancer patients' responses to learning their secondary findings arising from tumor genomic profiling, and the process and outcomes of their decisions to communicate these results…
- Trial name
- NCT02713334
- Testing
- survey, semi-structured interview
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colonic Polyp, Colorectal Cancer
Study on Second Forward View Examination in the Right Colon
It is estimated that there are about 1.4 million patients with colorectal cancer (CRC) worldwide, with a rising trend in CRC incidence in many Asian Pacific countries.
- Trial name
- NCT03121495
- Testing
- Second forward view (SFV) examination of the right colon
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cesarean Section
Reducing Cesarean Childbirth Rates Using the Hem-Avert Perianal Stabilizer
This study is being conducted to evaluate an FDA approved device called the HEM-AVERT® Perianal Stabilizer and the efficacy in reducing the C-section rate and/or reducing the second stage of labor times.
- Trial name
- NCT02167438
- Testing
- Hem-Avert Perianal Stabilizer
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Stetrix, Inc.
Human Papilloma Virus, Cervical Cancer
Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention
The project aims to increase HPV vaccination and cervical cancer screening through a web-based mobile health education program called, Wheel of Wellness (WoW) and a brief negotiated interview (BNI).
- Conditions
- Human Papilloma Virus, Cervical Cancer, Human Papillomavirus Infection, Oropharyngeal Cancer
- Trial name
- NCT03346915
- Testing
- WoW and BNI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Leukemia, Myelodysplastic Syndromes
Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients at risk of developing myelodysplastic syndrome may help doctors learn more about changes that occur in DNA and identify biomarkers related to…
- Trial name
- NCT00899327
- Testing
- DNA methylation analysis, RNA analysis, cytogenetic analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust