Clinical trials: Secondary Headache Disorders
Migraine Disorders, Headache Disorders, Primary
Individualized Prediction of Migraine Attacks Using a Mobile Phone App and Fitbit
This trial is collaboration between Mayo Clinic, Second Opinion Health (Simon Bloch, simon@somobilehealth.com 408-981-3814) and Allergan.
- Conditions
- Migraine Disorders, Headache Disorders, Primary, Headache Disorders, Brain Diseases
- Trial name
- Migraine Alert (NCT02910921)
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Second Opinion Health
Post-Dural Puncture Headache
Trans-nasal Sphenopalatine Ganglion Block Versus Ultrasound-guided Bilateral Greater and Lesser Occipital Nerve Block for Management of Post-Dural Puncture Headache.
Post-Dural Puncture Headache (PDPH) is a complication associated with spinal anesthesia. While conventional treatments are available, the Epidural Blood Patch (EBP) is considered the gold standard.
- Trial name
- TNSPGB /GALONB (NCT06705244)
- Testing
- Trans-nasal sphenopalatine nerve block, Greater and lesser occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Headache Disorders, Primary, Headache Disorders, Secondary
International Headache Registry Study
In the International Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as…
- Conditions
- Headache Disorders, Primary, Headache Disorders, Secondary, Migraine, Tension-Type Headache
- Trial name
- IHRS (NCT05418218)
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post-Traumatic Headache, Mild Traumatic Brain Injury
Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache
An exploratory open-label study of PPTH patients to study the efficacy and tolerability of erenumab in the prophylactic treatment of persistent headache attributed to mild traumatic injury to the head.
- Conditions
- Post-Traumatic Headache, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03974360
- Testing
- AMG 334
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Headache Center
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Cervicogenic Headache
Effects of Garston Tool and Neuromuscular Reeducation in Cervical Headache
Patients suffering from Cervicogenic headache have restricted range of motion and pain which in turn causes functional disability and reduced quality of life.
- Trial name
- NCT05849545
- Testing
- Garston tool, Neuromuscular Re-education
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Health Education Research Foundation (HERF)
Medication Overuse Headache
Ibudilast in the Treatment of Medication Overuse Headache
The purpose of this study is to determine if ibudilast is effective in reverting patients with medication overuse headache suffering chronic daily headache back to their original episodic headache pattern.
- Trial name
- NCT01317992
- Testing
- Ibudilast
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- University of Adelaide
Craniocerebral Trauma, Head Injury, Minor
Exercise in Patients With Post-Concussion Symptoms
Physical activity and exercise have traditionally not been much of a focus in treatment of postconcussion symptoms and posttraumatic headache.
- Conditions
- Craniocerebral Trauma, Head Injury, Minor, Postconcussion Syndrome, Posttraumatic Headache
- Trial name
- NCT04001192
- Testing
- aerobic exercise program
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Cervicogenic Headache
Muscle Energy Technique With And Without Myofascial Release in Patients With Cervicogenic Headache
This randomized controlled trial compared the effects of Muscle Energy Technique (MET) with and without Myofascial Release (MFR) in patients with cervicogenic headache.
- Trial name
- NCT07574112
- Testing
- Muscle Energy Technique (MET), Myofascial Release (MFR)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Post-Dural Puncture Headache
Evaluation of Post-dural Puncture Headache in Female Patients Undergoing Obstetric and Non-obstetric Surgery
The goal of this observational study is to compare the incidence, severity, and potential risk factors for Post-dural Puncture headaches (PDPH) in obstetric and non-obstetric female patients undergoing spinal anesthesia.
- Trial name
- NCT06992063
- Testing
- Spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Duzce University
Cervicogenic Headache, Occipital Neuralgia
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves at the top of the neck.
- Trial name
- NCT05491915
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- SPR Therapeutics, Inc.
Headache Disorders, Secondary, Headache Disorders
NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting
The NUMITOR study is an analytical observational study with an multicenter ambisective (retrospective and prospective) cohort design.
- Conditions
- Headache Disorders, Secondary, Headache Disorders, Central Nervous System Diseases, Brain Diseases
- Trial name
- NUMITOR (NCT05475769)
- Testing
- Clinical evaluation
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Post-spinal Headache
The Effect of Magnesium on Post-spinal Headaches
This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia
- Trial name
- NCT07502482
- Testing
- Magnesium
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Haseki Training and Research Hospital
Cervicogenic Headache, Third Occipital Nerve
Effectiveness of Third Occipital Nerve Pulsed Radiofrequency in Cervicogenic Headache
Cervicogenic headache is a secondary headache disorder originating from cervical spine structures and is frequently associated with chronic pain, functional limitation, and impaired quality of life.
- Trial name
- TON-PRF-CH (NCT07366060)
- Testing
- Third Occipital Nerve Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ankara City Hospital Bilkent
Postdural Puncture Headache
Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section
The parturients are at particular risk of post dural puncture headache (PDPH) because of their sex, young age, and the widespread application of spinal and epidural anesthesia.
- Trial name
- NCT03464253
- Testing
- Performance of the transcranial Doppler (TCD)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Medication-overuse Headache, Treatment
Treatment Response in Patients With Medication-Overuse Headache
The aim of this study to evaluate pre-injection patient-related factors that may influence treatment response in patients with medication-overuse headache who underwent ultrasound-guided greater occipital nerve block.
- Conditions
- Medication-overuse Headache, Treatment, Headache, Greater Occipital Nerve Block
- Trial name
- NCT07487649
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan 1. Murat State Hospital
Cervicogenic Headache
Effectiveness of a Novel Device for Cervical Training in Cervicogenic Headache.
The purpose of this study is to evaluate the clinical results in cervical spine range of motion, endurance deep cervical muscles, headache impact and physical activity enjoyment by a training protocol with the new device for…
- Trial name
- NCT05479149
- Testing
- Training protocol with the cervical device for treatment (CDAT)., Conventional training protocol
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Internacional de Catalunya
Cervicogenic Headache, Sleep Disturbance
Effect of Isometric Neck Exercises on Cervicogenic Headache Symptoms, Cortisol and BDNF Levels Among Smart Phone Users
Cervicogenic headache (CGH) is a secondary headache type caused due to refereed pain arising from the cervical spine in the forehead, sometimes in temporal region.
- Conditions
- Cervicogenic Headache, Sleep Disturbance, Stress
- Trial name
- NCT07354776
- Testing
- Isometric Neck Exercise Program, Usual Care
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared.
- Trial name
- NCT06069791
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University