Clinical trials: Sedation;
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Pediatric Sedation
Lullaby vs White Noise vs Silence in Pediatric MRI Sedation
This prospective randomized study aims to evaluate the effects of three auditory conditions-lullaby music, white noise, and silent headphone use-on sedation depth, anesthetic drug requirements, and recovery outcomes in children…
- Trial name
- CALMMRI (NCT07325331)
- Testing
- Silent Headphone, White Noise, Lullaby Music
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Mechanical Ventilation
Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in PICU
The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged…
- Trial name
- RESPIRE (NCT05064592)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Therapeutic Hypothermia
SEVOflurane Inhalation in CARdiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia
Studying the feasibility of an initial sedation with inhalated sevoflurane during therapeutic hypothermia of cardiac arrests resuscitated patients.
- Trial name
- SEVOCAR (NCT02201134)
- Testing
- sevoflurane
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Procedural Sedation
Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting
This single blinded parallel randomized clinical trial will be conducted on 50 patients presented to Emergency Department of Alexandria Main University Hospital who are indicated for procedural sedation.
- Trial name
- NCT06368219
- Testing
- ketamine- midazolam versus ketamine- propofol
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Oxygen Deficiency
Research of the Effect of Reservoir Oxygen Mask Application on Respiratory Parameters in Sedated Adult Patients for Gastrointestinal System Endoscopy
With the oxygen mask with reservoir, oxygen can be given to patients with FiO2 values that can reach 80-100%. Reservoir oxygen mask is superior to other oxygen treatment methods with the high oxygen rate applied.Our hypothesis is…
- Trial name
- NCT05684900
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Digestive System Diseases, Colonoscopy Sedation
Non-anesthesiologist Administered Propofol Sedation for Colonoscopy - a Randomized Clinical Trial
Propofol is the preferred sedation for colonoscopy. There is debate on the safety of the administration of propofol by non-anesthesiologists, despite moderate quality evidence that support its' use.
- Trial name
- NCT02067065
- Testing
- Non-anesthesiologist propofol sedation, Propofol sedation administered by an anesthesiologist, Colonoscopy
- Where
- Portugal
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Magnetic Resonance Imaging Contrast Media Adverse Reaction, Sedation Complication
Non-operating Room Anesthesia Experiences in Pediatric Magnetic Resonance Imaging Cases
In recent years, out patient anesthesia applications have been increasing for diagnostic and interventional procedures for pediatric patients.
- Trial name
- NCT05423821
- Testing
- Anesthesia efficacy in patients undergoing MRI
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yunus Emre
Post-operative Pain
QSPainRelief-patientCNS : Clinical Biomarkers of Nociception, Sedation and Cognition
QSPainRelief-patientCNS is a monocentric prospective longitudinal study conducted in patients suffering from disabling post-surgical pain for which the treating physician is about to prescribe a given drug combination for the…
- Trial name
- NCT04742790
- Testing
- Scalp electroencephalography (EEG), Laser-evoked potentials (LEPs), Cognitive auditory-evoked potentials (P300)
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Université Catholique de Louvain
Pain, Satisfaction
Randomized Controlled Trial Comparing Co2 vs. Air in Colonoscopy in Sedated Patients
CO2 insufflation instead of air for colonic distension in colonoscopy is considered to reduce pain after and during colonoscopy. There is limited data, that Co2 is similar effective in sedated patients.
- Trial name
- NCT00660296
- Testing
- Air insufflation use in colonoscopy, CO2 use in colonoscopy
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Sleep Deprivation, Delirium
Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
Specific Aims 1. Establish the feasibility of larger trial by implementing a sleep protocol in the ICU at 2 different sites. Specifically will be estimating the recruitment rates of patients and the compliance with both…
- Trial name
- SKY-DEX (NCT01791296)
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Sedation During GI Endoscopy
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5…
- Trial name
- NCT07423676
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Fractures
Ketamine/Propofol vs Ketamine Alone for Pediatric Fracture Reduction
The objective of this study is to compare Ketamine-Propofol with Ketamine-only in a double-blind, randomised, controlled trial in a paediatric emergency department.
- Trial name
- NCT00490997
- Testing
- Ketamine only, Ketamine - Propofol
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Patient Safety
Necessity of Transnasal Gastroscopy in Routine Diagnostics - a Patient Centered Requirement Analysis
Evaluation of patients safety and comfort in nasal endoscopy.
- Trial name
- NCT03663491
- Testing
- Nasal Gastroscopy, Oral Gastroscopy, unsedated, Oral Gastroscopy, sedated
- Where
- Germany
- Volunteers
- 283 people
- Sponsor
- University of Leipzig
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Sedation and Pain (The Effect of IV Sedation on Pain Perception)
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).
- Trial name
- NCT00853333
- Testing
- dexmedetomidine, midazolam, propofol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Respiratory Failure, Mechanical Ventilation Complication
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
There is a direct relationship between the sedative agent and the duration of ventilation.
- Conditions
- Respiratory Failure, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- NCT05451121
- Testing
- Propofol, Dexmedetomidine, Propofol and dexmedetomidine
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA
Digital Sedation
Healthy Volunteer Undergoing Painful Stimuli With and Without Hypnosis and Virtual Reality
The main purposes of this study are as follows: Compare the effect of painful stimuli with and without Hypnosis and Virtual Reality (HVR) on healthy volunteers.
- Trial name
- SMARTHY (NCT04107558)
- Testing
- Virtual Reality
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oncomfort