Clinical trials: Sedation;
Mechanical Ventilation, Respiratory Failure
The Emergency Department Sedation Pilot Trial
The ED-SED Pilot is a multicenter, prospective, before-and-after study conducted on 344 mechanically ventilated emergency department patients at three academic medical centers: Washington University in St.
- Trial name
- ED SED Pilot (NCT04410783)
- Testing
- Education, Standard post intubation sedation practices
- Where
- 3 sites in United States
- Volunteers
- 1,771 people
- Sponsor
- Washington University School of Medicine
Mental Function
Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
The purpose of this study is to see if mental functions take place during different levels of anesthesia. The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to…
- Trial name
- NCT05495945
- Testing
- Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI) using Propofol
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Brain, Sedation
Deep Brain Stimulation (DBS) Sedation
Deep brain stimulation (DBS) of different brain nuclei is a treatment for multiple brain disorders. The subthalamic nucleus (STN) and globus pallidus have been used to treat advanced Parkinson's disease for a long time.
- Trial name
- NCT03283150
- Testing
- Remifentanil, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Children Requiring Sedation to Facilitate Laceration Repair
Volumes of Administration for Intranasal Midazolam
The purpose of this study is to determine exactly how much drug volume should be administered into each nare, so that the drug absorption can be maximized and the amount that runs out of the nose, or is swallowed, is minimized…
- Trial name
- NCT01948908
- Testing
- Intranasal midazolam
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Columbia University
Pulmonary Hypertension
Sedation With Dexmedetomidine During Cardiac Catheterization
Clinical dose escalation drug trial to evaluate the effect of 3 different doses of dexmedetomidine on the pulmonary vascular bed in pediatric subjects with elevated pulmonary vascular resistance (PVR).
- Trial name
- NCT01072643
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Aruna Nathan
Respiratory Failure
Cycling of Sedative Infusions in Critically Ill Pediatric Patients
The purpose of this study is to determine if the reduction of the total amount of sedative critically pediatric ill patients receive in the PICU will achieve a significant decrease in mechanical ventilation days and a decrease in…
- Trial name
- NCT01333059
- Testing
- Midazolam, Normal saline, Fentanyl
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Javier Gelvez, MD
Colonoscopy
Combination of Water Immersion and Carbon Dioxide Insufflation for Minimal Sedation Colonoscopy
Water immersion insertion and carbon dioxide (CO2)instead of room air insufflation as alternative colonoscopy techniques have been documented to decrease patient discomfort during and after the procedure.
- Trial name
- Water/CO2 (NCT01440543)
- Testing
- Water immersion insertion AND CO2 insufflation, Water immersion insertion, CO2 insufflation
- Where
- Czechia
- Volunteers
- 420 people
- Sponsor
- Vitkovice Hospital
Tracheal Extubation
A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil…
- Trial name
- NCT01152515
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Severance Hospital
Procedural Sedation, Regional Anesthesia Block
Lusedra (Fospropofol Disodium) for Minimal to Moderate Sedation for Regional Anesthesia Block Prior to Orthopedic Surgery
How does Lusedra compare with current standard of care (midazolam) for minimal to moderate sedation for regional anesthesia blocks prior to orthopedic surgery?
- Conditions
- Procedural Sedation, Regional Anesthesia Block, Orthopedic Surgery
- Trial name
- NCT01195103
- Testing
- Fospropofol disodium, Fentanyl
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Sedation to be Moderate for a Diagnostic Gastrointestinal Endoscopy and Gastrointestinal Endoscopic Polypectomy
Phase III Study of ICI35,868 (Diprivan) With and Without EES0000645/A (SDS) on Gastrointestinal Endoscopy
This study is designed as a multi-centre, randomised, parallel-group, placebo-controlled, phase III confirmatory study. The study will be partially double-blinded: the comparison between Group 1 (placebo group) and Group 2…
- Trial name
- Kagami_SDS (NCT01961349)
- Testing
- Intralipid, ICI35,868 (Diprivan), ICI35,868 (Diprivan) + EES0000645/A (SDS)
- Where
- 3 sites in Japan
- Volunteers
- 279 people
- Sponsor
- AstraZeneca
Parkinson's Disease
Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine
This is a pilot study to explore the effects of pimavanserin and low-dose quetiapine in subjects with Parkinson's disease with neuropsychiatric symptoms.
- Trial name
- NCT04164758
- Testing
- Pimavanserin, Quetiapine
- Where
- 16 sites in United States
- Volunteers
- 11 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Sedation
Stress During Deep Sedation With Propofol With and Without Alfentanil
This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catecholamines before and after the procedure in…
- Trial name
- NCT00997113
- Testing
- propofol, alfentanil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hennepin Healthcare Research Institute
Procedural Sedation
Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
This will be a randomized trial of propofol versus the combination of propofol and ketamine for procedural sedation for procedures in the Emergency Department (ED).
- Trial name
- NCT01260662
- Testing
- Propofol, 1:1 Propofol/Ketamine, 4:1 Propofol/Ketamine
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Hennepin Healthcare Research Institute
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Conscious Sedation
Gabapentin to Improve Patient Tolerance in Endoscopic Retrograde Cholangiopancreatography (ERCP)
The standard approach to sedation in endoscopic retrograde cholangiopancreatography (ERCP) involves the use of benzodiazepines and opiates to achieve a moderate depth of sedation.
- Trial name
- NCT01143766
- Testing
- Gabapentin, Standard sedation regimen
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Indiana University
Anxiety
Comparison of Usual Care and Distraction (Tablet) in Children 3-5 Years Old
Randomized control trial comparing usual care and distraction (tablet) on anxiety, emergence delirium, sedation/agitation, and vomiting in children 3-5 years old
- Trial name
- NCT05368961
- Testing
- Distraction, Usual care
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU1 (NCT05312385)
- Testing
- Isoflurane, Propofol, Isoflurane (run-ins)
- Where
- 14 sites in United States
- Volunteers
- 277 people
- Sponsor
- Sedana Medical
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Procedural Sedation, Endoscopy
Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy
The purpose of this study was to assess the safety and efficacy of CNS 7056 as a procedural sedative at three dose levels compared to midazolam during a diagnostic upper GI endoscopy.
- Trial name
- NCT00869440
- Testing
- CNS 7056, Midazolam
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Paion UK Ltd.
Colonoscopy
Cap-assisted Water Immersion Versus Water Immersion Colonoscopy
Water immersion insertion has been documented to decrease procedure-related discomfort during colonoscopy. Cap attached to the colonoscope tip may improve insertion and shorten cecal intubation time.
- Trial name
- NCT01547247
- Testing
- soft straight distal cap D-201-14304 Olympus attached to the tip of the colonoscope, water immersion colonoscopy
- Where
- Czechia
- Volunteers
- 208 people
- Sponsor
- Vitkovice Hospital