Clinical trials: Sedation;
Cataract, Bilateral Senile Cataract
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
The goal of this pilot clinical trial comparing two different sedation approaches for cataract surgery is to assess the feasibility, completeness, and distribution of data in measuring patient satisfaction, the quality of…
- Conditions
- Cataract, Bilateral Senile Cataract, Anesthesia, Patient Satisfaction
- Trial name
- CaTNAPS-1 (NCT06506669)
- Testing
- Oral sedation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Advanced Cancer
The Effect of Donepezil on Sedation and Other Symptoms
Primary Objective: 1. To determine the effectiveness of donepezil as compared to placebo for the management of opiate-induced sedation/drowsiness in patients with stable cancer pain Secondary Objectives: 1.
- Trial name
- NCT00352664
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Pulmonary Diseases
Uncuffed Endotracheal Tube vs. no Endotracheal Tube
This is a comparison of uncuffed endotracheal tube (UCETT) vs. no endotracheal tube (ETT) in endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) procedure under moderate sedation in terms of procedure tolerance…
- Trial name
- NCT06799455
- Testing
- Endotracheal tube
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
Critical Illness
Combining Objective and Subjective Sedation Assessment Tools
The purpose of this study is to determine if the use of a device called the BIS monitor in addition to the Richmond Agitation Sedation Scale will give better assessment of a subject's level of sedation.
- Trial name
- COST_2 (NCT00734409)
- Testing
- Bispectral Index (BIS) Monitor
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Glioma
Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Sedation in the operating room, the Post Anesthesia Care Unit and the Intensive Care Unit is common and often necessary for patients with intracranial brain tumor.
- Trial name
- NCT02439164
- Testing
- Midazolam
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Procedural Sedation, Behavior Disorders
The Use of Dexmedetomidine for EEG Sedation in Children With Behavioural Disorders
Children's compliance during diagnostic or therapeutic procedures is a challenge, often requiring the use of sedative and/or analgesic drugs.
- Trial name
- NCT03799783
- Testing
- dexmedetomidine
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- Azienda Ospedaliera di Padova
Pain
Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
This study is a clinical trial of moderate sedation versus deep sedation with propofol for procedural sedation in the Emergency Department.
- Trial name
- NCT02404610
- Testing
- Moderate Procedural Sedation with a sedative medication., Deep Procedural Sedation with a sedative medication., propofol
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Hennepin Healthcare Research Institute
Apnea During Procedural Sedation
Electric Blower Based Ventilator Used During Procedural Sedation
Conduct human trials in the endoscopy suite of our continuous positive airway pressure (CPAP) ventilator approach using an FDA approved ventilator.
- Trial name
- NCT02621463
- Testing
- Noninvasive Ventilator (V60, Philips)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Utah
Amnesia, Pain
Memory Modulation by Pain During Anesthesia
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics.
- Conditions
- Amnesia, Pain, Anesthesia
- Trial name
- MMA (NCT02515890)
- Testing
- Dexmedetomidine, Midazolam, Peripheral nerve stimulation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sedation
Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)
This study is a clinical trial of moderate sedation with propofol versus moderate sedation with ketamine for procedural sedation in the Emergency Department.
- Trial name
- NCT00997321
- Testing
- propofol, Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hennepin Healthcare Research Institute
Sacroiliac Joint Pain, Sympathetically Maintained Pain
Effect of Sedation on Diagnostic Injections
Interventional pain procedures have diagnostic, prognostic and therapeutic value. It is well-documented that the reference standard for identifying a pain generator is a low-volume block performed with local anesthetic, with or…
- Trial name
- NCT01472835
- Testing
- Midazolam, Fentanyl
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Johns Hopkins University
Anesthesia, Endoscopy
Sedation Regimens in GI Endoscopy
This is a noninferiority study designed to examine whether conscious sedation with midazolam alone results in efficacy and safety that is not inferior to the combination of midazolam and fentanyl.
- Conditions
- Anesthesia, Endoscopy, Colonoscopy, Conscious Sedation
- Trial name
- NCT04807101
- Testing
- midazolam alone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Greg S Cohen MD LLC
MRI Sedation
Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
This is a randomized, double-blind, dose-ranging study of the efficacy and safety of dexmedetomidine (DEX) when used with propofol as needed, for procedural sedation of pediatric subjects ≥1 month to <17 years of age undergoing…
- Trial name
- NCT04237792
- Testing
- dexmedetomidine, propofol
- Where
- 23 sites in United States, Japan
- Volunteers
- 128 people
- Sponsor
- Pfizer
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Complex Partial Seizures
Intra Cranial EEG Activity During Dexmedetomidine Sedation
Various parts of the brain are sensitive to various anesthetics.We like to study the effect of dexmedetomidine on the different parts of the brain in patients who are coming for DBS electrode removal under sedation.
- Trial name
- NCT01648959
- Testing
- EEG Recording
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University Health Network, Toronto
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
Stroke
SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
Objectives: This study aims to estimate overall treatment benefit (improvement in disability) among acute ischemic stroke patients that are randomized to General Anesthesia (GA) compared with Sedation (CS) during endovascular…
- Trial name
- SEGA (NCT03263117)
- Testing
- Sedation, General Anesthesia (GA), Intra-arterial Thrombectomy
- Where
- 11 sites in United States
- Volunteers
- 260 people
- Sponsor
- The University of Texas Health Science Center, Houston