Clinical trials: Sedation During
Respiratory Failure, Sedation
Effects of NIV and CPAP on Ventilation Distribution, Measured by EIT, During Deep Sedation in Paediatric Patients
In patients undergoing spontaneous breathing (SB) deep sedation there is a re-distribution of ventilation towards lungs non-dependant areas (ventral areas in supine position).
- Conditions
- Respiratory Failure, Sedation, Mechanical Ventilation Complication
- Trial name
- NIVEIT-ped (NCT05495477)
- Testing
- EIT
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sufentanil, Remifentanil
Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation
The best opioid for bronchoscopy is still unclear.This randomized double-blind prospective study was conducted on a total of 60 patients who were randomly allocated into 3 groups: Group S received sufentanil 0.1 mcg/kg, Group F…
- Conditions
- Sufentanil, Remifentanil, Fentanyl, Bronchoscopy
- Trial name
- NCT03901716
- Testing
- Sufentanil, Fentanyl, Remifentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Nociception
Quantitative Consciousness Index Monitoring (qNOX) of Sedation During Endoscopy
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Trial name
- NCT06777589
- Testing
- Monitoring of anesthesia depth
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Min Su
Sedation Complication
Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP
After approval of ethical committee of Sindh Institute of Urology \& Transplantation (SIUT), 86 patients were enrolled for the elective endoscopic retrograde cholangiopancreatography (ERCP).
- Trial name
- NCT05996588
- Testing
- Propofol 1 % Injectable Suspension, Sevoflurane
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Requiring Sedation by Sevoflurane in ICU, Adult Patients
Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients
Describe the Richmond Agitation Sedation Scale (RASS) values corresponding to the values of Minimum alveolar concentration of sevoflurane during sedation of patients in ICU
- Conditions
- Requiring Sedation by Sevoflurane in ICU, Adult Patients, Patients Covered by French Health Care System, Patients Who Have Given Their Consent
- Trial name
- SEVORASS (NCT02202720)
- Testing
- Sevoflurane
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Stomach Neoplasm
Finding ED90 of Flumazenil for Selective Improvement of Respiratory Distress by Remimazolam
Patients undergoing endoscopic submucosal dissection with monitored anesthesia care (MAC) using remimazolam may develop respiratory distress during the procedure.
- Trial name
- NCT06563063
- Testing
- Flumazenil
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Continuous Positive Airway Pressure, Endoscopy
Nasal CPAP - The Treatment IMpact on Oxygenation in High-risk Patients During Deep Sedation for Endoscopy
Deep sedation during gastrointestinal endoscopy in patients with cardiopulmonary risk factors such as respective co-morbidities or also morbid obesity is challenging.
- Conditions
- Continuous Positive Airway Pressure, Endoscopy, Oxygenation, Obesity
- Trial name
- NAPTIME (NCT06168682)
- Testing
- SuperNO2VA™ Et by Vyaire Medical, Inc., nasal oxygen cannula
- Where
- Germany
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Complication of Anesthesia, Sedation-related Complications
Sedation-related Complications During Gastroenterological Procedures
Applications of non-operating room anesthesia for diagnosis and treatment are required in a variety of disciplines nowadays. Although it is not painful, sedation may be required in the gastrointestinal unit during procedures that…
- Trial name
- NCT05563727
- Where
- Turkey (Türkiye)
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Gazi University
Acute Respiratory Distress Syndrome
Sevoflurane PharmacokInetics in ARDS
The main objective of this study is to compare the pharmacokinetic models of sevoflurane-induced sedation during ARDS depending on the lung imaging phenotype (focal vs nonfocal phenotypes) The authors hypothesized that…
- Trial name
- SPIDERMAN (NCT04023305)
- Testing
- Deep sedation by Sevoflurane on the Morphotype of ARDS in ICU patieNts
- Where
- 3 sites in France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sedation, Endoscopy
Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy
Many studies address safety of non-anesthesiologist propofol sedation (NAPS) for gastrointestinal endoscopy. Target Controlled Infusion (TCI) is a sophisticated tool for providing optimal sedation regimen and avoiding under or…
- Trial name
- Propofol TCI (NCT02062177)
- Testing
- Propofol, Midazolam
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Università Vita-Salute San Raffaele
Sedation, Anesthesia, Spinal
Bispectral Index(BIS) on Depth of Sedation With Dexmedetomidine, Propofol and Midazolam During Spinal Anesthesia
This study is to investigate on the objective relevance between bispectral index (BIS) and Observer's assessment of alertness/sedation (OAA/S) scale in patients sedated with Midazolam, propofol and dexmedetomidine during spinal…
- Trial name
- BIS (NCT03399019)
- Testing
- Dexmedetomidine, Propofol, Midazolam
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Hallym University Medical Center
Colonoscopy Procedures, Sedation
Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy
"This prospective observational study aims to evaluate the effects of adding low-dose ketamine (0.25 mg/kg) to standard propofol sedation on hemodynamic stability, sedation depth, and recovery times in adult patients undergoing…
- Trial name
- NCT07809230
- Testing
- Propofol group, Propofol + Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara Etlik City Hospital
Arrhythmia
Virtual Reality to Reduce Intra-procedural Anxiety and Sedation Needs During Procedures
Researchers are assessing whether use of a virtual reality experience, used during the procedure, can reduce anxiety and improve satisfaction related to the procedure, especially when no or little sedation is being used.
- Trial name
- NCT04279665
- Testing
- Virtual Reality (VR)
- Where
- United States
- Sponsor
- Mayo Clinic
Movement Disorders, Effect of Remifentanil
Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients.
- Trial name
- NCT00588926
- Testing
- Remifentanil
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event
TEAS for Sedation During ERCP: A Multicenter Trial With Mechanistic Substudy
1. The goal of this clinical trial is to learn if transcutaneous electrical acupoint stimulation (TEAS), a non-invasive therapy that applies mild electrical current to specific points on the skin, can help patients undergoing…
- Conditions
- Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event, Procedural Pain, Sedation-related Complications
- Trial name
- TEAS-ERCP-MC (NCT07440342)
- Testing
- TEAS + Conscious Sedation
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Beijing 302 Hospital
Sedation
Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia
Controversies exist about the use of propofol in sedation of patients for cataract surgery. This prospective randomised double-blind study evaluates the efficacy of patient-controlled sedation compared with placebo using the same…
- Trial name
- CATARSIS (NCT02771912)
- Testing
- Propofol
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Conscious Sedation Failure During Procedure
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions
There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials.
- Trial name
- NCT00596050
- Testing
- ketamine and midazolam, etomidate, fentanyl, and lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Prematurity, Magnetic Field Exposure
Lateral Position MRI in Preterm Infants, an Observational Study
The goal of this observational study is to evaluate safety of sedation in lateral position in premature babies undergone MRI. The main question it aims to answer are: number of apneas during sedation Maintenance of eupnea during…
- Conditions
- Prematurity, Magnetic Field Exposure, Sedation Complication
- Trial name
- MRIOPS (NCT05776238)
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Administration Related Reaction, Failed Moderate Sedation During Procedure
Intranasal Dexmedetomidine VS Oral Chloral Hydrate for Rescue Sedation During Magnetic Resonance Imaging
The purpose of this investigation was to test the hypothesis that intranasal dexmedetomidine is as effective as second dose of oral chloral hydrate for rescue sedation in infant age between 1 and 6 months who were not adequately…
- Conditions
- Administration Related Reaction, Failed Moderate Sedation During Procedure, Chloral Hydrate Adverse Reaction
- Trial name
- NCT02239445
- Testing
- chloral hydrate Group, low dose dexmedetomidine group, high dose dexmedetomidine group
- Where
- 2 sites in China
- Volunteers
- 158 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Pain
Open Prospective Study for Determination of Predictive Measures for Pain During Colonoscopy
The aim of the study is to determine what precolonoscopic measures can be correlated to pain during colonoscopy
- Trial name
- NCT01496560
- Where
- Israel
- Sponsor
- Sheba Medical Center