Clinical trials: Sedation During
Percutaneous Endoscopic Gastrostomy (PEG)
Additional Benefit of Thoracic Impedance Monitoring (TIM) for Propofol-sedation Monitoring During PEG Placement
The present study is a randomized, prospective, single-blinded study. A total of 172 patients presenting for percoutaneous endoscopic gastrostomy (PEG) under sedation will be included according to the statistical sample size…
- Trial name
- TIMPEG (NCT04202029)
- Testing
- thoracic impedance monitoring, pulseoxymetry, non-invasive blood preassure monitoring
- Where
- Germany
- Volunteers
- 173 people
- Sponsor
- Georg Dultz
Hypoxemia During Surgery
Usefulness of High-flow Oxygen Therapy of Patients at Risk of Hypoxemia Undergoing Digestive Endoscopy Under Deep Sedation
The study investigates the use of high-flow oxygen therapy devices in patients at higher risk of complications during sedated digestive endoscopies.
- Trial name
- ENDOALF-TR (NCT07439822)
- Testing
- High-flow medical oxygen insufflation, Low-flow medical oxygen insufflation
- Where
- Spain
- Volunteers
- 326 people
- Sponsor
- Outcomes'10
Endoscopy, Colonoscopy
Can Nitrous Oxide (Laughing Gas) be Used as a Sedative for GI Endoscopy Procedures?
Nitrous oxide (commonly known as 'laughing gas') is often used during dental and other outpatient procedures, because it is easy to administer, is short-acting and rapidly clears from the body following the procedure.
- Trial name
- NCT05396144
- Testing
- 5% inhaled nitrous oxide, 50% inhaled nitrous oxide
- Where
- United States
- Sponsor
- Stanford University
Colonoscopy
Assessment of Ventilation Using Respiratory Volume Monitor Compared to Capnography During Intravenous Sedation
A. Determine if Respiratory Volume Monitor (RVM) can be used during procedural sedation to adequately monitor patient's respiratory status as compared to capnograph Aims B.
- Trial name
- NCT02860143
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Brigham and Women's Hospital
Endometrium; Hypertrophy, Cervix, Anesthesia
High Flow Oxygen During Operative Hysteroscopy.
High-flow nasal cannula (HFNC) oxygen therapy represents an open circuit ventilation system that uses flows up to 70 L/min of 100% oxygen through the Optiflow THRIVETM device (Fisher and Paykel Healthcare Ltd, Auckland, New…
- Conditions
- Endometrium; Hypertrophy, Cervix, Anesthesia, Apnea, Postanesthetic
- Trial name
- HOPE (NCT05550584)
- Testing
- Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE)., LMA
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Knee Replacement Surgery
The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia
The proposed study intends to investigate several aspects of the respiratory effects of intravenous sedation of patients undergoing spinal anesthesia for knee replacement surgery.
- Trial name
- NCT01622647
- Testing
- Nasal Continuous Positive Airway Pressure (NCPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pediatrix
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Conscious Sedation
Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma
Inadequate sedation and analgesia indicated by intraoperative movements are markers of inadequate MAC during burr-hole surgery for chronic subdural hematoma evacuation especially when general anesthesia poses high risk for the…
- Trial name
- NCT04621526
- Testing
- dexmedetomidine- ketamine, dexmedetomidine- propofol
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary
Magnesium for Neonatal Neuroprotection and Mothers
Magnesium is a treatment for mothers to protect brains of babies born early. This study investigates combined effects of magnesium and spinal or epidural anesthesia on mothers having cesareans.
- Conditions
- Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary, Respiratory Depression
- Trial name
- MnMs (NCT01482078)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Stress, Pain
Evaluation of the Surgical Pleth Index During Spinal and General Anesthesia
The Surgical Pleth index (SPI) has been introduced as a non invasive tool to "measure" stress and pain during surgery. Preliminary studies were performed in patients under general anaesthesia with propofol and remifentanil.
- Trial name
- NCT00789438
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University Hospital Schleswig-Holstein
Pain, Cancer
A Phase 2a, Proof-of-Concept Study of GIC-1001 in the Management of Visceral Pain During Sedation-Free, Full Colonoscopy
GIC-1001 is a novel, orally-administered, colonic analgesic drug developed as an alternative to i.v. sedation during full colonoscopy.
- Conditions
- Pain, Cancer, Colonic Diseases
- Trial name
- NCT01926444
- Testing
- GIC-1001
- Where
- 15 sites in United States, Canada
- Volunteers
- 308 people
- Sponsor
- gicare Pharma Inc.
Sedation
Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)
This study is a clinical trial of moderate sedation with propofol versus moderate sedation with ketamine for procedural sedation in the Emergency Department.
- Trial name
- NCT00997321
- Testing
- propofol, Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hennepin Healthcare Research Institute
Sedation, Spinal Anesthesia
Sedation Using Virtual Reality During Surgery Under Spinal Anesthesia
During spinal anesthesia, sedation is performed using intravenous sedative for the patient's comfort and appropriate surgical environment.
- Trial name
- NCT03055663
- Testing
- Sedation by watching virtual reality sedative program, Sedation by using intravenous sedative, Midazolam
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Hospital
Oral Sedation and Cervical Dilator Pain
Oral Sedation During Cervical Dilator Placement
This will be a randomized, double-blind, placebo-controlled trial involving 2 arms. It will be comparing the effects of placebo compared to 1 mg oral lorazepam/5 mg oral oxycodone on pain scores during cervical dilator placement…
- Trial name
- OSDI (NCT03202550)
- Testing
- Oxycodone and Lorazepam (Active Comparator)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Hypoventilation, Hypoxia
Using Capnography to Reduce Hypoxia During Pediatric Sedation
The investigators hypothesize that the addition of capnography during moderate sedation will improve recognition of hypoventilation and apnea.
- Trial name
- NCT01463527
- Testing
- Nellcor NPB-70 Capnograph
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Yale University
Complication
Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP
This is a single-center, prospective, randomized, double-blinded study of consecutive patients referred for ERCP. A recent study suggested that the addition of dexmedetomidine to the midazolam-meperidine regimen (MMD)provided…
- Trial name
- NCT02475824
- Testing
- Midazolam®, "Meperidine" (pethidine®), Propofol®
- Where
- South Korea
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Dankook University
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Brain, Sedation
Deep Brain Stimulation (DBS) Sedation
Deep brain stimulation (DBS) of different brain nuclei is a treatment for multiple brain disorders. The subthalamic nucleus (STN) and globus pallidus have been used to treat advanced Parkinson's disease for a long time.
- Trial name
- NCT03283150
- Testing
- Remifentanil, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Outpatient Colonoscopy
A Study to Examine Levels of Sedation During Outpatient Colonoscopies
Examine levels of sedation required for patients to comfortably undergo colonoscopy using propofol and if adjunct monitoring equipment promotes patient safety.
- Trial name
- NCT00614263
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Acute Respiratory Failure
Pharmacokinetic Alterations During ECMO
In a healthy patient, the lungs provide oxygen to the blood and remove carbon dioxide. However, in patients with severe lung failure, blood may not adequately be delivered to the lungs, or the lungs may not adequately supply…
- Trial name
- NCT01938079
- Testing
- Ketamine, Sedative drug regimen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University