Clinical trials: Sedation During
Asphyxia Neonatorum
Fentanyl and Clonidine for Analgesia During Hypothermia in Term Asphyxiated Infants
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in fentanyl and clonidine administered for analgesia and sedation to term newborn…
- Trial name
- SANNI 1 (NCT03177980)
- Testing
- Fentanyl, Fentanyl and clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 49 people
- Sponsor
- Region Skane
Impaired Airway Clearance
Fospropofol for Sedation During Elective Awake Intubation
Patients scheduled for awake fiberoptic intubation (AFI) because of potential difficult airway will be consented prior to intubation ASA Physical Status classification and history of difficult intubation will be recorded at…
- Trial name
- NCT01289483
- Testing
- fospropofol
- Where
- United States
- Sponsor
- The Cleveland Clinic
Pain
Safety and Efficacy of Carbon Dioxide Insufflation During Colonoscopy With Consecutive Esophagogastroduodenoscopy in Reduction of Abdominal Pain in Sedated Outpatients
Compared with performing each procedure individually, performing two combined procedures such as colonoscopy consecutive Esophagogastroduodenoscopy (EGD) cause more bowel gases, abdominal distension and post-procedure pain…
- Trial name
- COCE (NCT01450202)
- Testing
- bowel insufflation gas
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Inje University
Sedation
Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine
This study will compare 2 different sedation drugs (Ketamine and Midazolam) when they are used with another sedating medicine called Dexmedetomidine for MRI sedation.
- Trial name
- NCT02129426
- Testing
- Ketamine, Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Louisville
Patient Satisfaction
Use of Virtual Reality Technology as a Sedation Replacement During Colonoscopy
A pilot non-randomized controlled study examined whether the use of VR technology can serve as an appropriate substitute for sedation in a colonoscopy examination.
- Trial name
- NCT05701566
- Testing
- virtual reality headset, colonoscopy with standard sedation.
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hypothermia
Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial
The aim of this study is to increase knowledge about drug properties and effects during therapeutic hypothermia. The primary end point of this study is the time from termination of sedation to extubation in patients treated with…
- Trial name
- Cool Sedation (NCT00667043)
- Testing
- remifentanil and propofol, fentanyl and midazolam
- Where
- 2 sites in Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Transcatheter Aortic Valve Replacement, Procedural Sedation
Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation
Aortic valve stenosis is the most common valvular heart disease in the developed world, affecting 3,9% of population over 70 years of age.
- Trial name
- NCT03747432
- Testing
- Propofol, Dexmedetomidine
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Colon Neoplasm, Pain
Comparing Water Immersion and Water Exchange Methods During Minimally Sedated Colonoscopy
In minimally sedated Asian patients in a community setting the investigators showed that a limited volume of water infusion instead of air insufflation in either the rectal sigmoid colon or the whole colon significantly reduced…
- Trial name
- NCT01535326
- Testing
- air insufflation, water immersion, water exchange
- Where
- Taiwan
- Volunteers
- 270 people
- Sponsor
- Dalin Tzu Chi General Hospital
Gastric Adenoma, Gastric Cancer
Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection
Background: Endoscopic submucosal dissection (ESD) usually requires adequate level of sedation due to lengthy and uncomfortable procedure.
- Trial name
- NCT01157598
- Testing
- bispectral index monitoring
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Samsung Medical Center
Paediatric Flexible Bronchoscopy
Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy
The purpose of this study is to determine whether ketamine or propofol, drugs used for procedural sedation during paediatric bronchoscopy, results in higher operator satisfaction and better side effect profile.
- Trial name
- NCT02743104
- Testing
- Ketamine, Propofol, midazolam and atropine
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Pulmonary Hypertension
Sedation With Dexmedetomidine During Cardiac Catheterization
Clinical dose escalation drug trial to evaluate the effect of 3 different doses of dexmedetomidine on the pulmonary vascular bed in pediatric subjects with elevated pulmonary vascular resistance (PVR).
- Trial name
- NCT01072643
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Aruna Nathan
Conscious Sedation During Procedure, Endobronchial Ultrasound
Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound
The randomized controlled trial will compare efficacy and safety of dexmedetomidine to midazolam for sedation during endobronchial ultrasound
- Trial name
- NCT02713191
- Testing
- Dexmedetomidine, Midazolam bolus, Rescue midazolam
- Where
- India
- Volunteers
- 197 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Awake Fiberoptic Intubation
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation for Elective Awake Fiberoptic Intubation
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine versus placebo used for sedation during elective awake fiberoptic intubation.
- Trial name
- NCT00383890
- Testing
- Dexmedetomidine HCL Injection
- Where
- 17 sites in United States
- Volunteers
- 124 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Noninvasive Ventilation, Respiratory Insufficiency
Can High-flow Nasal Oxygenation Improve Oxygen Saturation During Analgo-sedation in Obese Adults?
Obesity is omnipresent problem in everyday anesthesiology practice associated with low level of blood oxygen (hypoxemia) during analgo-sedation.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Obesity, Deep Sedation
- Trial name
- NCT03687424
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Colonoscopy, Endoscopy, Digestive System
Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy
Patients routinely receive sedation during a colonoscopy or upper endoscopy (esophagogastroduodenoscopy; EGD) procedure. Propofol is a sedative that can be used during these procedures.
- Conditions
- Colonoscopy, Endoscopy, Digestive System, Conscious Sedation
- Trial name
- NCT00452426
- Testing
- Computer-Assisted Personalized Sedation (CAPS) Device (SEDASYS® System), benzodiazepines and opioid sedation
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ethicon Endo-Surgery
Satisfaction, Complication
CO2 Versus O2 Insufflation During ERCP Depending on Sedation Protocols
Endoscopic retrograde cholangiopancreatography(ERCP) and related procedures can cause abdominal pain and discomfort. Some clinical trials have indicated, using the visual analogue scale (VAS) score, that CO2 insufflation during…
- Trial name
- NCT01761474
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Soon Chun Hyang University
Health Check up Colonoscopy
Safety and Efficacy of Fentanyl Versus Pethidine During Propofol-based Sedated Colonoscopy: Prospective Randomized Study
During sedative colonoscopy, use of propofol have been increased world wide. The onset time of propofol is shorter than midazolam. However the most popular additive pain killer, pethidine show different pharmacodynamic feature.
- Trial name
- NCT02039453
- Testing
- fentanyl doses, pethidine dose
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Body Temperature Changes, Pediatric Anesthesia
Temperature Changes During Sedated Pediatric Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is widely used in pediatric patients and frequently requires sedation or general anesthesia. Both sedation and MRI-related environmental factors may influence thermoregulation.
- Conditions
- Body Temperature Changes, Pediatric Anesthesia, Magnetic Resonance Imaging
- Trial name
- NCT07455695
- Testing
- Sedation During MRI
- Where
- Turkey (Türkiye)
- Volunteers
- 285 people
- Sponsor
- Ankara Etlik City Hospital
Temperature Management During Sedation for Endoscopic Retrograde Cholangiography
Forced Air Heating to Prevent Hypothermia During Endoscopic Retrograde Cholangiography
The aim of this prospective observational study is to evaluate the role of a convective warming blanket to prevent hypothermia during sedation for an endoscopic retrograde cholangiography (ERC).
- Trial name
- FAIRHEC (NCT05138172)
- Testing
- Forced Air Heating Temperature control "Twinwarm II"
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- Hannover Medical School
Ventilation, Mechanical, Respiratory Insufficiency
Analgesia-Based Sedation During Mechanical Ventilation
Hypothesis: A protocolized algorithm for sedation in critically ill patients on mechanical ventilation can decrease ventilator days, costs and improve outcome.
- Conditions
- Ventilation, Mechanical, Respiratory Insufficiency, Critical Illness
- Trial name
- NCT00403208
- Testing
- Analgesia based sedation in ICU patients
- Where
- 14 sites in Chile
- Volunteers
- 280 people
- Sponsor
- Pontificia Universidad Catolica de Chile