Clinical trials: Sedation During
Hypoxia, Endoscopy
Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy
This study is a randomized controlled trial comparing oxygen delivery by nasal mask with continuous positive airway pressure versus standard care (nasal cannula or standard facemask) during propofol-based sedation for…
- Conditions
- Hypoxia, Endoscopy, Anesthesia Morbidity
- Trial name
- NCT03369197
- Testing
- Nasal Mask, Control: Nasal Cannula
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Anesthesia; Reaction
Dexmedetomidine-Propofol and Ketamine-Propofol During Upper Gastrointestinal System Sedation
Sedation with dexmedetomidine-propofol or ketamine-propofol was planned in patients with upper gastrointestinal endoscopy.
- Trial name
- NCT04399226
- Testing
- Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Anxiety, Pain
Verbal Suggestion to Reduce Pain and Anxiety During Unsedated Colonoscopy
Colonoscopy is an important diagnostic and screening procedure for colorectal diseases, but it can cause pain and anxiety, especially when performed without sedation.
- Conditions
- Anxiety, Pain, Colonoscopy, Patient Comfort
- Trial name
- NCT07228884
- Testing
- Verbal Suggestion
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Anesthesia, Cardiac Disease
High Flow Nasal Oxygen During Sedation
The primary objective of this study is to test the hypothesis that using high flow nasal oxygen improves ventilation during cardiac implantable electronic device procedures performed with conscious sedation.
- Trial name
- NCT03858257
- Testing
- High flow nasal oxygen, Standard oxygenation
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University Health Network, Toronto
Glycemia During Coronary Artery Bypass Graft, Sedation During Pre-anesthetic Medication
The Effect of Clonidine in Glycemia During Coronary Artery Bypass Graft With Cardiopulmonary By-pass
The purpose of this study is the randomized blind research of the assessment of the different levels of glycemia during Coronary Artery Bypass Graft (CABG) with cardiopulmonary by-pass (CPB) between clonidine and placebo.
- Trial name
- NCT01619436
- Testing
- Clonidine, Ringer lactato
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Federal University of Juiz de Fora
Sleep Apnea, Obstructive, Anesthesia
Pilot Study : New Sensors to Monitor Apnea During Sedation
Evaluation of a Mandibular and Abdominal Motion Detection Sensor (JAWAC) to Prevent Apnea During Sedation With Propofol in TCI Mode
- Trial name
- JAWAC (NCT02909309)
- Testing
- JAWAC system + Capnoline + Spo2
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Erasme University Hospital
Sleep Apnea
Clinical Predictors of Apnea-hypopnea During Propofol Sedation
To relate two different predictive values of sleep apnea: the STOP score (snoring while sleeping, daytime tiredness, observed breathing stoppages, and high blood pressure) and the estimated respiratory disturbance index (eRDI)…
- Trial name
- sleeposa (NCT01871259)
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Anesthesia, Surgical Procedures, Elective
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
The objective of this study is to evaluate the safety and efficacy of dexmedetomidine as compared to placebo when used for the sedation of subjects requiring monitored anesthesia care (MAC).
- Trial name
- NCT00398827
- Testing
- Dexmedetomidine
- Where
- 27 sites in United States
- Volunteers
- 326 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Sedation
Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU…
- Trial name
- NCT00158873
- Testing
- midazolam, lorazepam, fentanyl
- Where
- 15 sites in Netherlands
- Volunteers
- 224 people
- Sponsor
- GlaxoSmithKline
Anxiety
Melatonin vs Pregabalin for Anxiolysis and Sedation
preoperative melatonin, pregabalin or both will be given to all patients preoperative
- Trial name
- NCT05221151
- Testing
- Melatonin, Pregabalin, Ondansetron 4 MG
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Anesthesia; Reaction
Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Endoscopy in Hepatic Patients
We aim to compare the response to ketamine/dexmedetomidine and ketamine/propofol combinations used in hepatic patients with child-Pugh classification (class A), and early (class B) undergoing UGIE.
- Trial name
- NCT04906772
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tamer Nabil Abdelrahman
Sedation
The Utility of Pretracheal Stethoscope in Detecting Respiratory Abnormalities in Sedated Children
The purpose of the study is to validate the diagnostic performance of the amplified pretracheal stethoscope (APS) to detect sedation-related adverse acute respiratory events in propofol sedated nonintubated children.
- Trial name
- NCT01957566
- Testing
- APS
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Wisconsin, Madison
Conscious Sedation Failure During Procedure
Remifentanil Effect-site Prediction by Algometry
This study validates the pharmacodynamic analgesic predictions (effect) given by Minto's remifentanil pharmacokinetic and dynamic model in conscious sedation.
- Trial name
- NCT05115578
- Testing
- Remifentanil 1 MG Injection [Ultiva], Midazolam 1 MG/ML Prefilled Syringe, Saline solution
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Conscious Sedation During Procedure, Ablation of Arrhythmias
Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation
Complex procedures for treatment of cardiac arrhythmias are usually performed under deep sedation, since a quiet position of the patient is usually required over several hours and a significant risk of injury is caused by…
- Trial name
- TRACES (NCT04038476)
- Testing
- Standard monitoring + transcutaneous CO2 monitoring, Standard monitoring
- Where
- Germany
- Volunteers
- 726 people
- Sponsor
- University of Ulm
Sacroiliac Joint Pain, Sympathetically Maintained Pain
Effect of Sedation on Diagnostic Injections
Interventional pain procedures have diagnostic, prognostic and therapeutic value. It is well-documented that the reference standard for identifying a pain generator is a low-volume block performed with local anesthetic, with or…
- Trial name
- NCT01472835
- Testing
- Midazolam, Fentanyl
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Johns Hopkins University
Hypoxia, Hysteroscopy
The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
Hypoxia is a common adverse event during sedated hysteroscopy for assisted reproduction, and it is more likely to occur in overweight or obese patients.
- Conditions
- Hypoxia, Hysteroscopy, Overweight or Obesity
- Trial name
- RP (NCT06187896)
- Testing
- remimazolam, Propofol
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Biliary Tract Diseases, Pancreatic Diseases
Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)
Self-administration of propofol and opioid mixture by the patient him- or herself (patient-controlled sedation, PCS) could be successful alternative to the anesthesiologists-managed deep sedation during endoscopic retrograde…
- Trial name
- NCT01350037
- Testing
- alfentanil, remifentanil
- Where
- Finland
- Volunteers
- 81 people
- Sponsor
- Helsinki University Central Hospital
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Cerebral Palsy
Validity of Bispectral Index Monitoring During Deep Sedation
During Intramuscular botulinum toxin injections for children with cerebral palsy, immobility is essential to inject botulinum toxin to the right muscle.
- Trial name
- NCT02096549
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yeungnam University College of Medicine