Clinical trials: Sedation During
Inadequate; Pulmonary Function, Newborn
Use of ICON™ to Detect Hemodynamic Variables During Dexmedetomidine Sedation in Children Undergoing Pulmonary Function Test
To collect and analyze the physiologic data of the ICON™ during dexmedetomidine (DEX) sedation for neonatal pulmonary function testing.
- Trial name
- NCT03205943
- Sponsor
- Boston Children's Hospital
Tachycardia, Ventricular
Bispectral Index Monitoring During Testing in the Electrophysiology Lab
BACKGROUND Physician-guided moderate sedation, administered by a Registered Nurse has been the standard of practice for patients undergoing a wide range of electrophysiology procedures during the past decade.
- Trial name
- NCT00749671
- Testing
- Bispectral index monitoring, Ramsey Sedation Scale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baystate Medical Center
Anoxia
Cerebral Near-infrared Spectroscopy (NIRS) Monitoring Throughout Caesarean Deliveries
In this study the investigator would like to examine hemodynamic cerebral blood flow and brain function by the use of Invos cerebral oximetry in women undergoing cesarean section delivery.
- Trial name
- NCT02473978
- Testing
- INVOS Cerebral Oximetry
- Where
- Israel
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Intraocular Pressure Changes, Upper Gastrointestinal Endoscopy
Intraocular Pressure Changes During EGD
This prospective observational study evaluates short-term changes in intraocular pressure (IOP) during elective esophagogastroduodenoscopy (EGD) performed under routine sedation.
- Trial name
- ENDO-IOP (NCT07190508)
- Testing
- No Intervention (Observational)
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Sevim Şenol Karataş
Pain, Pediatric ALL
Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.
The ANI monitor is a medical device allowing to measure the response of the autonomic nervous system to a painful stimulus. In the pediatric population under general anesthesia, the ANI score can detect failure of locoregional…
- Trial name
- ANI-EP (NCT04913038)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Orthopedic Disorder
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
The purpose of this study is to compare the sedation efficacy of dexmedetomidine and remimazolam for intraoperative sedation during regional block.
- Trial name
- NCT05447507
- Testing
- Remimazolam, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sedation
Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy Gastrointestinal Endoscopy
comparison between propofol-fentanyl and propofol-ketamine for sedation in pediatric diagnostic gastrointestinal endoscopy.
- Trial name
- NCT03235609
- Testing
- Fentanyl, Ketamine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Drug Safety
Use of Intranasal Midazolam to Reduce Stress and Procedural Pain in Premature Infants During Routine ROP Examination.
The goal of this study is to learn about the safety and effectiveness of intranasal midazolam in newborns and infants born prematurely, undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06889376
- Testing
- Intranasal midazolam administration via the DART™ intranasal atomization device along with routine comfort care.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Emergence Reaction, Procedural Sedation
Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
To describe the safety and efficacy of nitrous oxide during ketamine administration for the prevention of emergence reaction during Emergency Department procedural sedation and analgesia in adults.
- Trial name
- NCT02145169
- Testing
- Inhaled Nitrous Oxide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein Healthcare Network
Conscious Sedation
Efficiency of Ventilation During Conscious Sedation in the Pediatric Intensive Care Unit
Pediatric patients admitted to the intensive care unit and requiring conscious sedation for minor surgical procedures are at risk to hypoventilate and retain CO2. The rise in CO2 levels is not well described and unpredicted.
- Trial name
- NCT01287572
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Liver Cirrhosis, Polyps of Colon
Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients
High flow nasal cannula oxygenation (HFNC) offers high flow and concentration oxygen delivery, providing excellent non-respiratory oxygenation. As a relatively new oxygen delivery method, it has gained widespread use.
- Conditions
- Liver Cirrhosis, Polyps of Colon, Gastrointestinal Dysfunction
- Trial name
- NCT07252102
- Testing
- High-flow nasal catheter oxygen, regular nasal catheter oxygen
- Where
- 3 sites in China
- Volunteers
- 450 people
- Sponsor
- Zhejiang University
Healthy, Covert Consciousness
Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study
This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine [with propofol in some participants] or ketamine), which shows areas in the…
- Trial name
- NCT07705022
- Testing
- Dexmedetomidine (+propofol as indicated), Ketamine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Procedural Sedation, Hypoxemia
HFNO Versus Face Mask for Cerebral Oxygenation During Procedural Sedation
This prospective randomized controlled trial aims to compare the effects of high-flow nasal oxygen (HFNO) and conventional face mask oxygen therapy on cerebral oxygenation during procedural sedation performed outside the…
- Conditions
- Procedural Sedation, Hypoxemia, Cerebral Oxygenation, SEDLine
- Trial name
- NCT07718295
- Testing
- High-Flow Nasal Oxygen (HFNO), Conventional Face Mask Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Firat University
Muscle Wasting in Critically Ill
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients.
- Trial name
- SPICE I (NCT07430969)
- Testing
- NMES, Amino acid bolus (20g), Standard enteral nutrition
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Wageningen University
Alveolar Hypoventilation Resulting in Hypoxemia
Capnography During Nurse Administered Propofol Sedation
Rationale: The current standard of respiratory monitoring for patients during deep sedation is continuous pulse oximetry with visual assessment of the patient.
- Trial name
- NCT01220765
- Testing
- Capnography
- Where
- Netherlands
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Acute Myocardial Infarction
Sevoflurane In Acute Myocardial Infarction
Ischemic postconditioning can reduce myocardial injury following myocardial infarction. A potential pharmacological agent is the anesthetic Sevoflurane.
- Trial name
- SIAMI (NCT00971607)
- Testing
- Oxygen + Sevoflurane
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Monitored Anesthesia Care
Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery
MgSO4 was found to reduce the perioperative anesthetic and analgesic requirements when used as an adjuvant to general anesthesia. Fentanyl is a potent opioid and used as adjuvant to other sedatives in awake craniotomy procedure.
- Trial name
- NCT03854812
- Testing
- Magnesium Sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Kasr El Aini Hospital
Endoscopic Hemostasis, Sedation
Endoscopic Hemostatic and Sedative Treatment of Esophageal and Gastric Variceal Bleeding
Remazolam besylate was used for sedation during endoscopic hemostasis in patients with esophageal and gastric varices rupture and bleeding in liver cirrhosis.
- Trial name
- NCT05554965
- Testing
- Propofol, Remimazolam besylate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Renmin Hospital of Wuhan University
Respiratory Distress Syndrome
Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome
In this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time…
- Trial name
- NCT00391105
- Testing
- Remifentanil
- Sponsor
- Federal University of Minas Gerais