Clinical trials: Sedation During
Renal Function Disorder, Postoperative Delirium
Conscious Sedation for Transcatheter Aortic Valve Implantation
Aortic valve stenosis is the heart valve disease with the highest prevalence among the elderly, and may lead to heart failure. Until recently, the only definitive treatment was surgical replacement (SAVR).
- Conditions
- Renal Function Disorder, Postoperative Delirium, Adverse Event, Death
- Trial name
- NCT05462938
- Testing
- Continuous infusion of propofol, Continuous infusion of dexmedetomidine
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- University of Ioannina
Sedation During Lower Extremity Surgery Under Spinal Anesthesia
Remimazolam Concentration and Sedation Depth During Lower Extremity Surgery Under Spinal Anesthesia
This study will examine how the amount of remimazolam predicted to reach its site of action relates to the depth of sedation during lower extremity surgery under spinal anesthesia.
- Trial name
- NCT07863063
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Conscious Sedation Failure During Procedure
Music Therapy in Procedural Sedation in the Emergency Department
The investigators propose to determine whether listening to classical music during a sedation procedure decreases the need for procedural sedation medication.
- Trial name
- NCT02676206
- Testing
- Classical music
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Sedation, Spinal Anesthesia
Sedation With Remimazolam During Spinal Anesthesia
Remimazolam is a benzodiazepine-binding site antagonist of the GABA receptor, metabolized by esterases, and exhibits a stable context-sensitive half-life of 6-7 minutes.
- Trial name
- NCT05305248
- Testing
- Remimazolam, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Gangnam Severance Hospital
Healthy Participants
Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation
The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol.
- Trial name
- NCT07161518
- Testing
- Low-intensity transcranial ultrasound, Propofol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Conscious Sedation Failure During Procedure
Ketofol Versus Propofol in Urgent ERCP for Acute Cholangitis
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a lengthy and uncomfortable procedure that requires adequate sedation. Propofol is the commonly used sedative during ERCP.
- Trial name
- NCT04997967
- Testing
- Ketamine/Propofol, Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION
High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA)
This study aims to evaluate the effects of high-flow nasal oxygen therapy on respiratory complications, blood gas parameters, and post-procedural recovery in patients undergoing sedated endobronchial ultrasound-guided…
- Conditions
- High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Sedation, Sedation Complication
- Trial name
- NCT07760727
- Testing
- High-Flow Nasal Oxygen Therapy, Conventional Oxygen Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Bronchoscopy
Narcotrend Versus Bispectral Index Monitoring During Sufentanil-Midazolam Anesthesia for Bronchoscopy
This study was aimed to determine whether narcotrend monitoring was better than bispectral index monitoring during sufentanil-midazolam anesthesia for bronchoscopy under conscious sedation.
- Trial name
- NCT03738137
- Testing
- Narotrend, BIS, Sufentanil
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Hypoxia
The 90% Effective Flow of High Flow Nasal Oxygenation (HFNO) During Sedated Bronchoscopy
Patients undergoing sedated bronchoscopy were randomized into six groups (10 Liters/minute [L/min], 20 L/min, 30 L/min, 40 L/min, 50 L/min, 60 L/min). The primary outcome was the incidence of hypoxemia.
- Trial name
- HFNO (NCT05298319)
- Testing
- high flow nasal cannula
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang Cancer Hospital
Nephrogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis
The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who…
- Trial name
- NCT04939753
- Testing
- Sevoflurane
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Universitair Ziekenhuis Brussel
Propofol
Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation
This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy.
- Trial name
- NCT06756594
- Testing
- Dexmedetomidine-Propofol, Ketamine-Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Medically Assisted Procreation (MAP), Oocyte Retrieval
Monocentric Randomised Controlled Trial to Assess Whether Virtual Reality Reduces the Use of Hypnotic Agents During IVF/ICSI Oocyte Retrieval
Over the last few years, audiovisual distraction devices using animation, films and 3D immersion have been developed, with the aim to provide patients with a relaxing experience that disconnects them from the operating…
- Trial name
- REVAHPOVO (NCT07190729)
- Testing
- Propofol sedation + Audiovisual distraction, Propofol sedation
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Heart Failure, Excessive Amount of Blood / Fluid Transfusion
Anesthesia for Catheter Aortic Valve ImplantATIOn Registry
In modern cardiac surgery and cardiology Transcatheter Aortic Valve Implantation (TAVI) is an emerging procedure for high-risk patients that are assumed to be otherwise inoperable.
- Conditions
- Heart Failure, Excessive Amount of Blood / Fluid Transfusion, Intraoperative Cardiac Arrest During Cardiac Surgery, Critical Incident
- Trial name
- AVIATOR (NCT01390675)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Patient Compliance
Propofol Spinal Procedural Sedation for Cesarean Section
Patient's safety and satisfaction are major concerns of anesthesiologists and obstetricians. According to evidence, guidelines and quality markers, regional anesthesia is preferred over general anesthesia in obstetric surgery.
- Trial name
- NCT03437980
- Testing
- propofol
- Where
- 3 sites in Egypt
- Volunteers
- 228 people
- Sponsor
- Mansoura University
Sedation
Pharmacokinetic of Sevoflurane During a 48h Sedation in Intensive Care Unit With AnaConDa®
This is a prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sevoflurane.
- Trial name
- Anaconda (NCT01196754)
- Testing
- sevoflurane
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Gastro-Intestinal Disorder
Effect of Palatable Lidocaine Gel on Gag Reflex for Patients Undergoing Upper Gastrointestinal Endoscopy
The development of upper gastrointestinal endoscopy (UGIE) has greatly expanded the diagnostic and therapeutic capabilities of gastroenterologists.
- Trial name
- NCT04213833
- Testing
- Propofol Injection [Diprivan], Dexmedetomidine [Precedex], Palatable Lidocaine Topical Gel
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Endoscopy
Integrated Pulmonary Index in Gastroscopic Procedures
Various complications are the leading cause of morbidity in sedation practices in endoscopic procedures, and guidelines recommend continuous monitoring of circulation, respiratory function, and ventilation.
- Trial name
- NCT05829486
- Testing
- gastroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Sedation
Stress During Deep Sedation With Propofol With and Without Alfentanil
This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catecholamines before and after the procedure in…
- Trial name
- NCT00997113
- Testing
- propofol, alfentanil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hennepin Healthcare Research Institute
Gastrointestinal Endoscopy
Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial
One of the most common adverse events during sedated gastrointestinal endoscopy is hypoxemia, which can lead to serious consequences.
- Trial name
- NCT07079176
- Testing
- etomidate combined with propofol, propofol
- Volunteers
- 732 people
- Sponsor
- RenJi Hospital