Clinical trials: Sedation and Analgesia
Burning Nose
Using Intranasal Midazolam (INM) and Lidocaine for Uncooperative Children
Aims: The objective of the current study was to evaluate the effectiveness of topical lidocaine in relieving pain related to INM administration. Design: This was a blinded, randomized placebo-controlled trial.
- Trial name
- INM (NCT03725995)
- Testing
- Midazolam, Lidocaine-Midazolam
- Where
- Syria
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Latakia University
Cirrhosis, Chronic Hepatitis
Sedation and Analgesia for Transjugular Liver Biopsy: A Randomized Double Blind Placebo Controlled Trial
Transjugular liver catheterisation allows the measurement of hepatic venous pressure gradient (HVPG) and the sampling of liver tissue but patient's tolerance to the procedure is unknown.
- Conditions
- Cirrhosis, Chronic Hepatitis, Anxiety
- Trial name
- NCT00596414
- Testing
- transjugular liver biopsy, midazolam, midazolam + pethidine
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Erasme University Hospital
Critical Illness, Sedation Complication
Sedation, ANalgesia and Delirium MANagement in Intensive Care Unit
Patients with acute severe health problems often need to be admitted to specialised hospital wards called Intensive Care Units (ICUs) where they can receive emergency treatment such as mechanical ventilation to support their…
- Conditions
- Critical Illness, Sedation Complication, Intensive Care Unit Delirium, Analgesia
- Trial name
- SAnDMAN (NCT05027217)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,421 people
- Sponsor
- University of Oxford
Effect of Drug, Complication of Treatment
Dexmedetomidine as a Sole Premedication for BMT Placement
There is very little evidence or research documenting any single method of sedation/analgesia for myringotomy tube (BMT) placement as being more effective than others.
- Trial name
- BMT (NCT05903326)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Nemours Children's Clinic
Optic Nerve Sheath Diameter
The Application of Ultrasonic Measurement of Optic Nerve Sheath Diameter in Liposuction Surgery
The main purpose of this study is to investigate the effect of changes in Optic Nerve Sheath Diameter (ONSD) measured at different operating position during Liposuction Surgery.
- Trial name
- NCT06685952
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Pain, Acute, Surgical Procedure, Unspecified
Surgical Intervention in Deep Sedation: No Pain or no Memory
The goal of this observational study is to assess the levels of nociception in deeply sedated patients who need painful and short-duration surgical procedure.
- Trial name
- SedNOL (NCT06963749)
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- ASL Novara
Valvular Cardiac Surgeries
Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation
Postoperative sedation is an essential component in recovery of the patient undergoing cardiac surgery. It facilitates the patient's unawareness of the environment as well as reduce the discomfort and anxiety caused by surgery…
- Trial name
- NCT06464263
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egymedicalpedia
Procedural Sedation and Analgesia
Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
The purpose of this study is to compare the effectiveness of the co-administration of intravenous ketamine and propofol to intravenous ketamine as a single agent for procedural sedation in the pediatric emergency department.
- Trial name
- NCT01387139
- Testing
- Ketamine, Ketamine Co-administered with Propofol
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Colorado, Denver
ICU-acquired Weakness, Mechanical Ventilation
eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness
This single-center, prospective, randomized controlled trial aims to evaluate whether an eCASH concept-based analgesia and sedation strategy combined with early goal-directed mobilization can reduce the incidence of intensive…
- Conditions
- ICU-acquired Weakness, Mechanical Ventilation, Critical Illness
- Trial name
- eCASH-EGDM (NCT07677488)
- Testing
- eCASH-Based Analgesia and Sedation Strategy Combined With Early Goal-Directed Mobilization, Routine ICU Nursing Care
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Conscious Sedation, Postoperative Analgesia
Analgo-Sedative Effects Of Oral, Or Nebulized Ketamine In Pre-schoolers Undergoing Elective Surgery.
the primary objective of this study is to investigate the sedative, and analgesic effects of oral, or nebulized ketamine as premedication drugs, and providing postoperative analgesia for the preschoolers and decrease their need…
- Trial name
- NCT03885427
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Sedation
Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial
The purpose of this study is to determine if procedural sedation utilizing a 1:1 mixture of propofol and ketamine is equivalent in complications, patient and physician satisfaction, post-procedure pain level, and procedural…
- Trial name
- NCT01269307
- Testing
- 1:1 ketamine-propofol mixture sedation, Propofol Sedation
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Utah
Craniotomy, Neurosurgical Patients
an Analgesia-first Strategy Without Hypnotic Sedatives in Adult Patients Admitted to the Intensive Care Unit After Neurosurgical Craniotomy
Analgesia and sedation are core components of intensive care unit (ICU) care. They are used to relieve pain and anxiety, prevent harmful physiological stress responses, improve tolerance of invasive devices and mechanical…
- Trial name
- NCT06727435
- Testing
- analgesia-first strategy without hypnotic sedatives
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Beijing Tiantan Hospital
Critical Illness
the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation
Remifentanil is one kind of opiates with strong analgesic effect,which has the rapid onset and short lasting duration. Remifentanil usually is used to help reducing the pain of patients with mechanical ventilation in ICU.
- Trial name
- NCT02635802
- Testing
- Remifentanil, Lidocaine, Remifentanil+Lidocaine
- Volunteers
- 1,500 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Respiratory Distress Syndrome
Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome
In this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time…
- Trial name
- NCT00391105
- Testing
- Remifentanil
- Sponsor
- Federal University of Minas Gerais
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Intensive Care Units
- Trial name
- SEEDS (NCT05466708)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Music Therapy for Pain and Sedation, Neck Pain Musculoskeletal
Musical Mindfulness for Pain in the ED Waiting Room
Studies have shown that 60-70% of patients in the Emergency Department (ED) experience pain. With pain being such a broad issue in the ED, the ED is expected to deliver safe and effective treatment of pain.
- Conditions
- Music Therapy for Pain and Sedation, Neck Pain Musculoskeletal, Back Pain
- Trial name
- NCT07391891
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Irvine