Clinical trials: Sedation and Analgesia
Behavior Management
Effect of Audio-analgesia Using Binaural Beats and Instrumental Music on the Behaviour of Minimally Sedated Pediatric Patients
The aim of this study is to evaluate the effect of audio analgesia (using binaural beats and instrumental music) in conjunction with a minimal dose of intranasal aerosolized midazolam on acquiring satisfactory patient cooperation.
- Trial name
- NCT07770321
- Testing
- Audio analgesia, 0.3 mg/kg midazolam, 0.5 mg/kg midazolam
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Rania Ahmedien
Pain Management, Injection Pain Prevention
Testing the Timing and Application of Virtual Reality Distraction During Knee Injections in a VA Pain Clinic
The goal of this clinical trial is to learn whether virtual reality (VR) can be added to routine knee injection appointments at a VA outpatient pain clinic without slowing down or disrupting clinic operations.
- Conditions
- Pain Management, Injection Pain Prevention, Virtual Reality, Feasibility Studies
- Trial name
- NCT07884851
- Testing
- Immersive Virtual Reality
- Volunteers
- 45 people
- Sponsor
- Atlanta VA Medical Center
Intensive Care (ICU), Respiratory Distress Syndrome (RDS)
Feasibility of Protocolised Analgosedation in ECMO
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care (ICU), Respiratory Distress Syndrome (RDS), Sedation and Analgesia, Extracorporeal Membrane Oxygenation
- Trial name
- ECMO-SED (NCT07580781)
- Testing
- Sedation protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Anesthesia, Sedation
Gastro-laryngeal Tube During Transesophageal Echocardiography
To analyze the effects of the use of Gastro-laryngeal Tube on intraoperative and postoperative hemodynamics, procedure comfort, and cardiologist and patient satisfactions during transesophageal echocardiography.
- Conditions
- Anesthesia, Sedation, Analgesia, Airway Complication of Anesthesia
- Trial name
- GLT (NCT05272306)
- Testing
- Number of attempts for successful transesophageal echocardiography, A questionnaire for cardiologist satisfaction, A questionnaire for patient satisfaction
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Bezmialem Vakif University
Delirium
Instruments for Delirium Assessment Regarding to Analgesia Sedation and Ventilator Status
In this prospective, multicenter observational study we assess the diagnostic validity of the following standard screening instruments for delirium regarding sedation, analgesia and ventilator status in critically ill patients…
- Trial name
- IDEAS (NCT01720914)
- Where
- 2 sites in Brazil, Germany
- Volunteers
- 160 people
- Sponsor
- Charite University, Berlin, Germany
Pain
Bispectral Index as an Analgesia Monitoring in Severely Ill Patient: Effect of Remifentanyl
The aim of this protocol is to study the prophylactic effect of remifentanil on bispectral index variation during a nociceptive stimuli.
- Trial name
- NCT00162591
- Testing
- remifentanyl
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Anesthesia
Intranasal Dexmedetomidine Sedation and Analgesia During Pediatric Emergency Room Procedures
The study objective is to determine if intranasal dexmedetomidine is a safe and effective sedative drug during small painful procedures in the pediatric emergency room.
- Trial name
- INDEXER (NCT03564093)
- Testing
- Intranasal Drug
- Where
- Finland
- Volunteers
- 112 people
- Sponsor
- University of Oulu
Neurology, Newborn
SWC on aEEG in Post-surgical Neonates on Morphine and Midazolam
Objectives: Sleep characteristics have been used for prediction of neuro-developmental outcome. The aim of our study was to evaluate the influence of morphine and midazolam on the development of SWC in newborns > 32 weeks'…
- Conditions
- Neurology, Newborn, Analgesia, Sedation
- Trial name
- NCT01212419
- Volunteers
- 47 people
- Sponsor
- Royal Children's Hospital
Sedation and Analgesia, Side Effect of Drug
The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department
The purpose of this study is to evaluate the anti-emetic effect of oral ondansetron. For this evaluation, the investigators will perform a multi-center, double-blind, placebo-controled, randomized study.
- Trial name
- NCT01477242
- Testing
- Ondansetron
- Where
- South Korea
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Hypertension, Resistant, Sympathectomy
Procedural Sedation in Renal Sympathetic Denervation
This retrospective, single-center study investigates the effects of two different sedation regimens-dexmedetomidine versus fentanyl-propofol-on clinical outcomes in patients undergoing catheter-based renal sympathetic denervation…
- Conditions
- Hypertension, Resistant, Sympathectomy, Conscious Sedation, Procedural Sedation and Analgesia
- Trial name
- NCT07293273
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ebru Girgin Dinc
Sedation and Analgesia, Pain Intensity Assessment
Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units
Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and/or emotionally.
- Conditions
- Sedation and Analgesia, Pain Intensity Assessment, Mechanical Ventilation Complication
- Trial name
- PainICU (NCT07182851)
- Where
- 4 sites in Brazil
- Volunteers
- 370 people
- Sponsor
- Centro Universitário Augusto Motta
Procedural Sedation and Analgesia
Combined Ketamine/Propofol for Emergency Department Procedural Sedation
Introduction Numerous drugs and combinations of drugs are used for procedural sedation and analgesia (PSA) in Emergency Departments, including propofol, ketamine, benzodiazepines, narcotics, barbiturates, and others, but propofol…
- Trial name
- NCT01126957
- Testing
- Ketamine, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Withdrawal Syndrome, Iatrogenic Disease
AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)
Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high.
- Trial name
- NCT04422808
- Where
- United States
- Volunteers
- 2,437 people
- Sponsor
- Wilkes University
Analgesia
Methoxyflurane for Analgesia During Hysteroscopy
This study is to assess the non-inferiority of using inhaled methoxyflurane (MOF) versus intravenous conscious sedation with fentanyl and midazolam on women's perception of pain, during hysteroscopy and/or polypectomy in an…
- Trial name
- NCT06899724
- Testing
- Anesthetics, Inhalation, Intravenous Sedatives with or Without Analgesia
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Dr. John A. Thiel Medical Professional Corporation
Pain, Anesthesia
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3.
- Trial name
- NCT04691076
- Testing
- Propofol, Esketamine, Fentanyl
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Union Medical Center
Conscious Sedation
Procedural Sedation And Analgesia in Children in the Emergency Department: The Role of Adjunct Therapies
The role of Adjunct therapies such as Child Life therapy and Music listening during Procedural Sedation and Analgesia(PSA) for children during painful procedures has not been studied in the Emergency Department (ED).
- Trial name
- NCT02518919
- Testing
- Child life intervention, Music listening
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Children's Hospital of Michigan
Procedural Sedation
Procedural Sedation Using Propofol Versus Midazolam/Ketamine in the Adult Emergency Department
The use of procedural sedation and analgesia (PSA) to accomplish painful procedures in the emergency department (ED) has become a standard of practice over the last decade.
- Trial name
- NCT00784498
- Testing
- Ketamine/Midazolam, Propofol
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sedation, Preoperative Anxiety Experienced by the Pediatric Patient
Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.
This study aims to compare intranasal dexmedetomidine versus intranasal ketamine as a premedication in children undergoing surgery in our population.
- Conditions
- Sedation, Preoperative Anxiety Experienced by the Pediatric Patient, Anxiolytic Effect, Sedation and Analgesia
- Trial name
- DREAM-Kids (NCT07180095)
- Testing
- Intranasal dexmedetomidine, Intranasal ketamine
- Volunteers
- 60 people
- Sponsor
- Liaquat National Hospital & Medical College
Analgesia
Comparison of Different Ratio of Ketofol (6:1 vs. 4:1) for Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP)
Study was aimed to compare the effect of ketofol between 6:1 and 4:1 ratio in patients who underwent ERCP
- Trial name
- NCT04029831
- Testing
- Propofol and Ketamine Mixture (Ketofol)
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- Universitas Indonesia