Clinical trials: Sedation for Mechanical Ventilation
Respiratory Distress Syndrome
Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome
In this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time…
- Trial name
- NCT00391105
- Testing
- Remifentanil
- Sponsor
- Federal University of Minas Gerais
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Intensive Care Units
- Trial name
- SEEDS (NCT05466708)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- ISO-DRIVE (NCT06014138)
- Testing
- Propofol, Isoflurane
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Analgesia, Postoperative Pain
The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
This trial intends to evaluate Remimazolam Besylate's availability and safety compared with propofol.
- Trial name
- NCT04947345
- Testing
- Remimazolam Besylate, Propofol
- Volunteers
- 84 people
- Sponsor
- Peking Union Medical College Hospital
Patient Requiring Mechanical Ventilation
Evaluation of Mirus™ for Sedation in Resuscitation
Current recommendations for the conduct of sédationanalgésie ICU encourage the use of the lightest possible sedation strategies, avoiding the administration of benzodiazepines source of longer durations of ventilation and ICU…
- Trial name
- MIRUS (NCT02889055)
- Testing
- patient requiring the MIRUS (mechanical ventilation)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Grenoble
Intubated Requiring Sedation for Greater Than 48 Hours
AnaConDa Long Term Sedation Study
Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial…
- Trial name
- VALTS (NCT01983800)
- Testing
- Isoflurane, Propofol/midazolam
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Sepsis
Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial
Background: Dexmedetomidine, a highly selective arfa2-adrenergic agonist, is known to be a unique sedative agent which causes less acute tolerance, drug addiction and withdrawal compared with gamma-aminobutyrate (GABA) agonists.
- Trial name
- DESIRE (NCT01760967)
- Testing
- Dexmedetomidine
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Wakayama Medical University
Early Systolic Blood Pressure Control Rate, Hematoma Growth
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment
This study evaluates safety and efficacy of analgesia-first minimal sedation as an early antihypertensive treatment for spontaneous intracerebral hemorrhage.
- Conditions
- Early Systolic Blood Pressure Control Rate, Hematoma Growth, Blood Pressure Variability, Healthcare Worker Satisfaction
- Trial name
- ASSICHH (NCT03207100)
- Testing
- Analgesia-first minimal sedation, Antihypertensive treatment
- Where
- 17 sites in China
- Volunteers
- 338 people
- Sponsor
- Hong Yang
Sedative, Mechanical Ventilation
Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients
A randomized non-inferior trial comparing remimazolam besylate with propofol for short-term sedation during invasive mechanical ventilation in intensive care units
- Trial name
- NCT05782894
- Testing
- Remimazolam besylate, Propofol, Remifentanil
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sedation for Mechanical Ventilation
Use of Ketamine Associate With an Opioid for Sedation in ICU
The aim of the study is to evaluate the impact of ketamine associated to an opioid for sedation of mechanically ventilated critically ill patients versus placebo. Sedation will be drive by nurses according to an algorithm.
- Trial name
- KetaRea (NCT01560390)
- Testing
- Rémifentamil + KETAMINE, ketamine
- Where
- France
- Volunteers
- 164 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Sedation, Intubation
GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
Patients who are in the intensive care unit after surgery and require mechanical breathing support (intubation and ventilation) usually require sedation to avoid agitation and excessive stress responses.
- Conditions
- Postoperative Sedation, Intubation, Respiration, Artificial
- Trial name
- NCT00125398
- Testing
- AQUAVAN (fospropofol disodium; GPI 15715 )
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eisai Inc.
Aged, Intensive Care Units
Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients
Patients with mechanical ventilation in the intensive care unit (ICU) often develop anxiety and agitation, sleep distuebances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes.
- Conditions
- Aged, Intensive Care Units, Ventilators, Mechanical, Dexmedetomidine
- Trial name
- NCT06468436
- Testing
- Dexmedetomidine-Esketamine Combination, Dexmedetomidine
- Where
- 3 sites in China
- Volunteers
- 1,508 people
- Sponsor
- Peking University First Hospital
Acute Respiratory Failure, Anxiety
Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients
Mechanical ventilation (MV) is the most frequently used life-support modality in intensive care units (ICUs). To reduce anxiety, stress and promote tolerance of MV, nurses frequently administer a variety of sedative medications…
- Trial name
- PCS (NCT01606852)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU2 (NCT05327296)
- Testing
- Isoflurane, Propofol
- Where
- 16 sites in United States
- Volunteers
- 282 people
- Sponsor
- Sedana Medical
Sedation, Mechanical Ventilation
Sedation in ICU Patients With Mechanical Ventilation
Background: Sedation is a cornerstone of management for mechanically ventilated patients in the intensive care unit (ICU). Achieving early target sedation while maintaining hemodynamic stability remains a major clinical…
- Trial name
- NCT06538883
- Testing
- Ciprofol, Sedation with Propofol
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Zhongda Hospital
Analgesia
Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation.
The aim of this study is to better define the pharmacokinetic and pharmacodynamic profile of lorazepam for the analgosedation in pediatric intensive care unit.
- Trial name
- NCT04646135
- Testing
- Lorazepam 4 mg/ml
- Volunteers
- 9 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Sedation
A Study Evaluating the Efficacy and Safety of HSK3486 for Sedation
This is a multi-center, open-label, randomized, propofol-controlled phase II clinical trial.A total of ICU patients undergoing mechanical ventilation are intended to be enrolled and randomly assigned to HSK3486 group and propofol…
- Trial name
- NCT04147416
- Testing
- HSK3486 0.1-0.2 /0.3 mg / kg group, Propofol 0.5-1.0/1.5 mg/kg group
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd