Clinical trials: Sedation in Intensive Care
Sleep Deprivation, Delirium
Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
Specific Aims 1. Establish the feasibility of larger trial by implementing a sleep protocol in the ICU at 2 different sites. Specifically will be estimating the recruitment rates of patients and the compliance with both…
- Trial name
- SKY-DEX (NCT01791296)
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Post Intensive Care Syndrome (PICS), Critical Illness
"PROTECT-ICU: Impact of an Educational Intervention
Brief Summary The goal of this study is to learn if a structured training program for intensive care unit (ICU) staff can reduce health problems after a stay in the ICU in adults.
- Trial name
- PROTECT-ICU (NCT07542613)
- Testing
- Standardized Training on the ABCDEF Care Bundle (A-F), Standardized training on the expanded ABCDEF care bundle (A-Z)
- Where
- 2 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Carola Giménez-Esparza Vich
Intellectual Disability, Perceptual Disorders
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes.
- Conditions
- Intellectual Disability, Perceptual Disorders, Memory Disorders
- Trial name
- RESTORE-cog (NCT02225041)
- Where
- 31 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Delirium, Pain
Evaluation of Quality Indicators on Analgesia, Sedation and Delirium in Intensive Care Patients and Their Impact on Outcome Indicators and Economic Indicators
Retrospective cohort study to investigate the adherence to the process indicators for pain management, sedation management and management of delirium on outcome indicators and cost/revenues in individual patients and subcohorts.
- Trial name
- NCT05384613
- Where
- Germany
- Volunteers
- 20,220 people
- Sponsor
- Charite University, Berlin, Germany
Pain, Agitation, Emergence
Management of PADIS in Emergency Intensive Care Unit
Investigate the prevalence of PADIS in EICU, as well as the awareness and clinical implementation status of medical staff towards PADIS.
- Conditions
- Pain, Agitation, Emergence, Delirium, Critical Illness
- Trial name
- NCT06339385
- Testing
- PADIS assessment
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Capital Medical University
Deep Sedation, Intensive Care Pediatric
Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation
Pharmacokinetic monitoring of midazolam, it's active metabolite and fentanyl in pediatric patients with long-term analgosedation will be performed.
- Trial name
- Morpheus (NCT02302391)
- Testing
- PK analysis
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Delirium, Agitation
Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium
The purpose of the research is to see if dexmedetomidine (a drug that has a calming effect - a sedative) is effective for the treatment of acute delirium
- Trial name
- NCT00351299
- Testing
- Dexmedetomidine, Standard of Care
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Critical Illness
Pupillometry and Nociception Level Index for the Evaluation of Pain in Intensive Care Unit.
Pain is a frequent symptom in the intensive care unit (ICU). Critical ill patients are often intubated and sedated which makes self-evaluation of pain impossible.
- Trial name
- NOCI-ICU (NCT05469841)
- Testing
- Systemic pain assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- MIDEX (NCT00481312)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 43 sites in Belgium, Estonia and 7 more
- Volunteers
- 501 people
- Sponsor
- Orion Corporation, Orion Pharma
Critical Illness
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.
- Trial name
- NCT05870514
- Testing
- Fospropofol disodium for injection, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaobo Yang, MD
Cardiac Surgery
Comparison of Propofol Based Versus Volatile Based Anesthesia and Postoperative Sedation
All patients undergoing cardiac surgery require intraoperative anesthesia and short-term postoperative sedation with anesthetic agents after the procedure when patient is in the intensive care unit (ICU).
- Trial name
- NCT01151254
- Testing
- Isoflurane/sevoflurane, Propofol
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University Health Network, Toronto
Procedural Sedation
Intranasal Ketamine and Midazolam Mixture for Procedural Sedation in Children With Mental Disabilities:
Ketamine and Midazolam are well known sedative drugs that can be given through different routes such as intravenous, intramuscular, oral, rectal and intranasal route.
- Trial name
- NCT03860831
- Testing
- Ketamine + midazolam
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Delirium, Respiratory Depression
Acupuncture for Sedation in the Intensive Care Unit (ICU)
BACKGROUND Many patients in the trauma intensive care unit (TICU) require mechanical ventilation and sedation or anxiolysis. Mechanical ventilation means that a machine is helping a patient breathe if he can't breathe on his own.
- Conditions
- Delirium, Respiratory Depression, Overmedication
- Trial name
- NCT01362270
- Testing
- Verum Acupuncture
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Nociceptive Pain, Sedation Complication
Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care Unit
Due to their underlying pathology and the necessary complicated procedures to which they are exposed, patients in the intensive care unit experience varying degrees of pain at some point in their evolution.
- Trial name
- NCT05399758
- Testing
- NOL monitor
- Where
- 2 sites in Chile
- Sponsor
- University of Chile
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Pain, Pediatric ALL
Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.
The ANI monitor is a medical device allowing to measure the response of the autonomic nervous system to a painful stimulus. In the pediatric population under general anesthesia, the ANI score can detect failure of locoregional…
- Trial name
- ANI-EP (NCT04913038)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Critically Ill, Intensive Care Unit Delirium
Physical Restraints in Intensive Care Unit Patients
The use of physical restraints is common practice in Intensive Care Units (ICU). This medically prescribed procedure requires full attention of medical and paramedical teams for its implementation, monitoring and ending, as a…
- Conditions
- Critically Ill, Intensive Care Unit Delirium, Delirium Confusional State, Agitation,Psychomotor
- Trial name
- ARBORéa (NCT04957238)
- Testing
- ARBORea decision-making tool
- Where
- 19 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Clermont-Ferrand