Clinical trials: Sedation in the ICU
Sepsis, Agitation
Safety Study of Dexmedetomidine in Septic Patients
Septic patients in Intensive Care Unit always need mechanical ventilation and conscious-sedation. But the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range.
- Trial name
- NCT01976754
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Critical Illness
Pupillometry and Nociception Level Index for the Evaluation of Pain in Intensive Care Unit.
Pain is a frequent symptom in the intensive care unit (ICU). Critical ill patients are often intubated and sedated which makes self-evaluation of pain impossible.
- Trial name
- NOCI-ICU (NCT05469841)
- Testing
- Systemic pain assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Mechanical Ventilation, Sedation
Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use
The purpose of the study is to develop and implement an evidence-based analgesia-sedation algorithm in the pediatric intensive care unit (PICU) using quality improvement and implementation science methodology.
- Trial name
- NCT04263662
- Testing
- Analgesia-Sedation algorithm
- Where
- United States
- Volunteers
- 680 people
- Sponsor
- Boston Children's Hospital
Sedation
Long-term Clinical Study Evaluating the Safety and Efficacy of Dexmedetomidine in ICU Subjects
Evaluate efficacy and safety of dexmedetomidine long term administration in ICU patients who require more than 24 hours sedation.
- Trial name
- NCT00526760
- Testing
- Dexmedetomidine
- Where
- 10 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Sedative, Mechanical Ventilation
Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients
A randomized non-inferior trial comparing remimazolam besylate with propofol for short-term sedation during invasive mechanical ventilation in intensive care units
- Trial name
- NCT05782894
- Testing
- Remimazolam besylate, Propofol, Remifentanil
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sedation and Analgesia, ICU
EICU Analgesia and Sedation Cross-sectional Survey
Sedation and analgesia is a very important part of the comprehensive treatment of critically ill patients. The comprehensive management strategy of sedation and analgesia in the Intensive Care Unit (ICU) and the control of…
- Trial name
- EASY (NCT04674540)
- Testing
- No Intervention
- Where
- China
- Volunteers
- 1,195 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Sedation, Intubation
GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
Patients who are in the intensive care unit after surgery and require mechanical breathing support (intubation and ventilation) usually require sedation to avoid agitation and excessive stress responses.
- Conditions
- Postoperative Sedation, Intubation, Respiration, Artificial
- Trial name
- NCT00125398
- Testing
- AQUAVAN (fospropofol disodium; GPI 15715 )
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eisai Inc.
Critical Care
Improved ICU Outcomes With Protocolized Management of Analgesia, Sedation and Delirium
To assess pain, agitation, and delirium experienced by critically ill patients daily and evaluate the impact of a protocol; to compare the incidence of coma and delirium, length of stay, mortality and costs of care between pre…
- Trial name
- NCT00506649
- Testing
- protocol
- Where
- Canada
- Volunteers
- 1,214 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Nephrogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis
The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who…
- Trial name
- NCT04939753
- Testing
- Sevoflurane
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Universitair Ziekenhuis Brussel
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Critical Illness
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
The aim of the study was to describe the feasibility of the nociception flexion reflex and the pupillary dilatation reflex as objective pain assessment tools in the Intensive Care Unit (ICU).
- Trial name
- NCT02916004
- Testing
- Measurement of NFR and PDR
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Critically Ill Patients
BIS in Critically Ill Patients in ICU
The Bispectral Index (BIS) is a monitor that converts brain electrical activity from EEG into a simple number from 0 to 100. A higher number means the patient is more awake, while a lower number means deeper sedation or reduced…
- Trial name
- NCT07583732
- Testing
- Processed EEG monitoring
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
ICU Sedation
Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit
To evaluate the efficacy, safety, and pharmacokinetics of dexmedetomidine given as continuous IV infusion in pediatric subjects [≥ 45 weeks CGA (corrected gestational age) to <17 years old] requiring sedation under intensive care…
- Trial name
- NCT02757625
- Testing
- Dexmedetomidine hydrochloride
- Where
- 12 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Pfizer
Microcirculation
Comparison Between Dexmedetomidine and Propofol for Patients in the Intensive Care Unit After Abdominal Surgery
This is a single-blind randomized clinical trial. Patients undergoing abdominal surgery will be enrolled and randomly divided into two groups: dexmedetomidine group and propofol group.
- Trial name
- NCT02874768
- Testing
- Dexmedetomidine, Propofol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Sedation
Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU…
- Trial name
- NCT00158873
- Testing
- midazolam, lorazepam, fentanyl
- Where
- 15 sites in Netherlands
- Volunteers
- 224 people
- Sponsor
- GlaxoSmithKline
Post Intensive Care Syndrome (PICS), Critical Illness
"PROTECT-ICU: Impact of an Educational Intervention
Brief Summary The goal of this study is to learn if a structured training program for intensive care unit (ICU) staff can reduce health problems after a stay in the ICU in adults.
- Trial name
- PROTECT-ICU (NCT07542613)
- Testing
- Standardized Training on the ABCDEF Care Bundle (A-F), Standardized training on the expanded ABCDEF care bundle (A-Z)
- Where
- 2 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Carola Giménez-Esparza Vich
Delirium, Pain
The Effect of Music on Delirium, Pain, Need of Sedation, Anxiety and Vital Parameters
The purpose of this study is to test the effect of a twice daily, 60-minute, nurse initiated, music listening intervention on patients followed in the ICU with MV support as compared to patients who receive care as usual and ear…
- Conditions
- Delirium, Pain, Sedation, Anxiety
- Trial name
- NCT05082623
- Testing
- Music, Earplug
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Ege University
Delirium
The ABCDEF Bundle in Critical Care: a French National Survey Still a Long Way to go!
The goal of this observational study is to evaluate the knowledge and compliance of French intensive care units with the ABCDEF (A: Assessment, Prevention, Management of Pain, B: Both Spontaneous Awakening Trials and Spontaneous…
- Trial name
- NCT06344013
- Where
- France
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest