Clinical trials: Segment Elevation Myocardial Infarction (STEMI)
ST-elevation Myocardial Infarction (STEMI)
Drug-Coated Balloon Versus Drug-Eluting Stent in Patient With ST-Segment Elevation Myocardial Infarction
Acute ST-segment elevation myocardial infarction (STEMI) is a life-threatening emergency requiring immediate intervention. The incidence of premature coronary artery disease (PCAD) is rising rapidly in China; its long-term…
- Trial name
- DCB-STEMI (NCT06742125)
- Testing
- Drug-coated balloon (DCB), Drug-eluting stent (DES)
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myocardial Infarction
FFR Versus Angiography-Guided Strategy for Management of AMI With Multivessel Disease
The aim of the study is to compare clinical outcomes following fractional flow reserve (FFR)-guided versus angiography only guided strategy in treatment of non-infarction related artery (non-IRA) stenosis in patients with acute…
- Trial name
- FRAME-AMI (NCT02715518)
- Testing
- PCI using 2nd generation drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
STEMI, Coronary Microvascular Dysfunction
Super Saturated Oxygen (SSO2) Therapy in Patients With ST-segment Elevation Myocardial Infarction (STEMI) and Action on Coronary Microcirculation Dysfunction
The goal of this clinical trial is to demonstrate the improvement in Coronary Microcirculation Dysfunction (CMD) with Super Saturated Oxygene (SSO2) therapy in patients with anterior ST-segment Elevation Myocardial Infarction…
- Trial name
- IC-HOT-MICRO (NCT05790876)
- Testing
- SSO2 therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction
OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS
This study evaluates the completeness of strut coverage and vessel wall response, at different time points (3-6-12 Months), following CordimaxTM stent implantation in patients with non-ST elevation acute coronary syndrome
- Trial name
- NCT02868203
- Testing
- OCT, eLuting stent
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
Dutch Cangrelor Registry
Cangrelor is a fast and directly acting platelet aggregation inhibitor. It is potentially indicated for several types of patients who are undergoing PCI.
- Conditions
- STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Coronary Artery Disease
- Trial name
- NCT04138641
- Testing
- Cangrelor
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Isala
Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS)
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers
Oxygen treatment is widely used in acutely ill patients, both pre-hospital and in hospital. The indication for oxygen is sometimes unquestionable, such as in many hypoxic patients, but in other situations its use is more of a…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), ST Elevation (STEMI) Myocardial Infarction, Ischemic Reperfusion Injury
- Trial name
- DETO2X-bio (NCT02290080)
- Testing
- Oxygen
- Where
- 2 sites in Sweden
- Volunteers
- 175 people
- Sponsor
- Karolinska Institutet
Non-ST Segment Elevation Myocardial Infarction
Anfibatide Phase Ib-IIa Clinical Trial
Investigate the safety and efficacy of Anfibatide in non-ST segment myocardial infarction patients
- Trial name
- NCT01585259
- Testing
- Anfibatide
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Lee's Pharmaceutical Limited
Thromboembolism
Michelangelo - Oasis 5
Study Objectives PRIMARY OBJECTIVE: To evaluate whether fondaparinux is at least as effective as or superior to enoxaparin in preventing death, myocardial infarction or refactory ischemia up to Day 9 in the acute treatment of…
- Trial name
- NCT00139815
- Testing
- Fondaparinux, enoxaparin
- Volunteers
- 20,078 people
- Sponsor
- GlaxoSmithKline
Arrythmia -Myocardial Infarction
Identification of Risk Factors for the Occurrence of High-grade Rhythm Disorders in Patients With ST-segment Elevation Myocardial Infarction (STEMI)
The goal of this study is to identify the risk factors for the occurrence of arrythmia in patient with stemi in prehospital management.
- Trial name
- STEMI (NCT05040919)
- Testing
- collection of medical and socio-demographic data
- Where
- France
- Volunteers
- 652 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients
This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g.
- Conditions
- ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05698719
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 111 people
- Sponsor
- Erasmus Medical Center
Myocardial Infarction, ST Elevation Myocardial Infarction
10-Years Follow-up of the EXAMINATION Trial
The EXAMINATION trial was a superiority trial that compared everolimus-eluting stents (EES) versus bare-metal stents (BMS) in an all-comer ST-segment elevation myocardial infarction (STEMI) population.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Infarction, Necrosis
- Trial name
- EXAMINAT10N (NCT04462315)
- Testing
- Everolimus Eluting Coronary Stent System, Cobalt chromium balloon expandable stent (non-drug-eluting stent Arm)
- Where
- 11 sites in Italy, Netherlands and 1 more
- Volunteers
- 1,498 people
- Sponsor
- Hospital Clinic of Barcelona
ST-segment Elevation Myocardial Infarction
EROSION II: OCT Guided PPCI in STEMI
This protocol describes a prospective, multi-center study intended to test the hypothesis that patients with STEMI caused by plaque rupture or plaque erosion without obstructive stenosis (diameter stenosis <70%) can be stabilized…
- Trial name
- NCT03062826
- Testing
- dual antiplatelet therapy (aspirin + ticagrelor or aspirin + clopidogrel)
- Where
- 16 sites in China
- Volunteers
- 347 people
- Sponsor
- Harbin Medical University
Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI)
Non-stenting Treatment Strategy for Acute Myocardial Infarction With Non-severe Stenosis(EROSION IV)
This study is a prospective, multicenter, open-label, non-inferiority, randomized controlled trial. A total of 2,000 patients with STEMI (<24 hours or 7-14 days) or NSTEMI will be recruited from at least 20 centers in China.
- Conditions
- Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction(NSTEMI)
- Trial name
- NCT07567625
- Testing
- Guideline-recommended standard medical therapy alone, DES implantation plus guideline-recommended standard medical therapy
- Where
- 48 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Harbin Medical University
ST-Segment Elevation Myocardial Infraction
IK-1001 (Sodium Sulfide (Na2S) for Injection) in Subjects With Acute ST-Segment Elevation Myocardial Infarction
Myocardial Infarctions (MI) are commonly known as heart attacks. An ST-Segment Elevation Myocardial Infarction (STEMI) is a more severe type of heart attack.
- Trial name
- NCT01007461
- Testing
- Sodium Sulfide (Na2S) for Injection
- Sponsor
- Mallinckrodt
Myocardial Infarction, Acute
Mechanocardiography in Patients With STEMI
The study aim is to evaluate the capability of mechanocardiography in detecting acute myocardial ischemia in patients suffering evolving ST-segment elevation infarction.
- Trial name
- MECHANO-STEMI (NCT03441724)
- Testing
- Mechanocardiography
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Turku
ST-segment Elevation Myocardial Infarction
Remote Ischemic Perconditioning in Patients With ST-segment Elevation Myocardial Infarction
To evaluate whether remote ischemic per-conditioning (RIPC) can reduce infarct size in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention (PPCI) within 12 hours of…
- Trial name
- CAPRI (NCT02164695)
- Testing
- PPCI plus RIPC, PPCI only
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Yonsei University
ST Segment Elevation Myocardial Infarction
Italian Multi-center Registry of Self-apposing Coronary Stent in Patients With STEMI
The aim of this registry is to collect clinical data on nitinol self-expanding STENTYS Xposition S™ in order to evaluate the efficacy and safety in patients presenting with ST segment elevation myocardial infarction
- Trial name
- iPOSITION (NCT02979236)
- Testing
- STENTYS Xposition S
- Where
- 8 sites in Italy
- Volunteers
- 250 people
- Sponsor
- UOSD Emodinamica Diagnostica e Interventistica
ST Segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
In STEMI patients undergoing PPCI there is a delayed onset of action of oral P2Y12 receptor inhibitors, including prasugrel and ticagrelor.
- Trial name
- CANTIC (NCT03247738)
- Testing
- Cangrelor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
STEMI
The Protective Effect of Prostaglandin on Coronary Microcirculation and Ventricular Remodeling After Reperfusion Therapy in Acute ST-segment Elevation Myocardial Infarction
To explore the protective effect of prostaglandin sodium on coronary microcirculation function and ventricular remodeling after reperfusion treatment of acute ST-segment elevation myocardial infarction.
- Trial name
- NCT05043558
- Testing
- beprostaglandin sodium
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shenzhen People's Hospital
ST Segment Elevation Myocardial Infarction, Elective Percutaneous Coronary Intervention
Prevention of Coronary Slow Flow or No-Reflow During EPCI in Patients With Acute STEMI
Elective percutaneous coronary intervention (EPCI) is the common treatment of ST segment elevation myocardial infarction (STEMI).Slow flow / no-reflow phenomenon following EPCI in STEMI patients has been a serious and common…
- Trial name
- NOSLOWFLOW-Ⅱ (NCT03406832)
- Testing
- Nitroprusside Sodium, Tirofiban Hydrochloride, Heparinized saline
- Where
- 28 sites in China
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University