Clinical trials: Segment Elevation Myocardial Infarction (STEMI)
ST-segment Elevation Myocardial Infarction
Manual Thrombus Aspiration During PCI in STEMI With Angiographically Evident Thrombus
The goal of this clinical trial is to determine whether manually removing a visible blood clot before percutaneous coronary intervention (PCI) improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- TAPSET (NCT06654453)
- Testing
- Manual thrombus aspiration, Percutaneous Coronary Intervention
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Shenghua Zhou
Predictive Value of Admission Blood Glucose Level in Acute Myocardial Infarction
Predictive Value Of Admission Blood Glucose Level In Patients With Acute Myocardial Infarction
Coronary atherosclerosis is the leading cause of death worldwide. Diabetes mellitus is associated with increased prevalence of coronary artery disease Increased plasma glucose is a common feature in the acute phase of myocardial…
- Trial name
- NCT03164707
- Testing
- Blood Glucose Level
- Volunteers
- 100 people
- Sponsor
- Assiut University
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
IVUS Versus FFR for Non-infarct Related Artery Lesions in Patients With Multivessel Disease and Acute MI
The aim of the study is to compare clinical outcomes between intravascular ultrasound (IVUS)-guided treatment decision versus fractional flow reserve (FFR)-guided treatment decision for non-infarct related artery stenosis in…
- Trial name
- FRAME-AMI2 (NCT05812963)
- Testing
- IVUS-guided PCI group, FFR-guided PCI group
- Where
- 2 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Samsung Medical Center
ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention
The investigators evaluate the efficacy and safety of intravenous administration of nicorandil as adjuncts to reperfusion treatment in acute ST-segment elevation acute myocardial infarction (STEMI) patients undergoing primary…
- Trial name
- CLEAN (NCT04665648)
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Fudan University
Coronary Disease, Coronary Artery Disease
MGuard Stent and Microcirculation
NSTE-ACS represents the most frequent indication for coronary angiography and percutaneous coronary intervention (PCI) worldwide.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Atherosclerosis, Cardiovascular Diseases
- Trial name
- GUARDIANCORY (NCT03087175)
- Testing
- MGuard stent, Drug eluting stent and bare metal stent
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble
Myocardial Infarction (MI), ST-Elevation Myocardial Infarction
Drug-Coated Balloon Primary PCI in ST-Segment Elevation Myocardial Infarction
Drug-eluting stent (DES)-based primary percutaneous intervention (pPCI) has been established as the standard of care for patients presenting with ST-segment elevation myocardial infarction (STEMI), having demonstrated superiority…
- Conditions
- Myocardial Infarction (MI), ST-Elevation Myocardial Infarction, STEMI, STEMI (STE-ACS)
- Trial name
- DCB-STEMI (NCT07436429)
- Testing
- Drug-Coated Balloon
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
NSTEMI
Efficacy of Oral Ivabradine in Patients Presenting With NSTEMI
This study aims to evaluate the beneficial effect of heart rate reduction of oral ivabradine in patients presenting with non ST-segment elevation myocardial infarction (NSTEMI) during acute stage post percutaneous coronary…
- Trial name
- NCT04285736
- Testing
- Ivabradine, Conventional Treatment
- Volunteers
- 100 people
- Sponsor
- Cairo University
Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI)
Predictive Value of NT-proBNP on MACEs After Acute Coronary Syndrome
The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a cardiac biomarker in predicting short-term major adverse cardiovascular events (MACEs) in patients with Acute coronary syndrome (ACS) has been insufficiently…
- Conditions
- Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Major Adverse Cardiac Events
- Trial name
- MACEstdy (NCT06569511)
- Testing
- N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitive cardiac troponin T (hs-cTnT)
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Haseki Training and Research Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Acute Myocardial Infarction
The SORT OUT IX STEMI OCT Trial
The aim of the Danish Organization for Randomized Trials with Clinical Outcome (SORT OUT) IX STEMI OCT is to compare early vascular healing of the polymer-free Biolimus-eluting BIOFREEDOM stent with a biodegradable-polymer…
- Trial name
- OCT STEMI SOIX (NCT02915107)
- Testing
- BioFreedom, Orsiro
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Odense University Hospital
Myocardial Infarction, Angioplasty, Transluminal, Percutaneous Coronary
Efficacy Study of Erythropoietin After Revascularization in Myocardial Infarction (REVIVAL-3)
The purpose of this study is to determine whether erythropoietin is superior to placebo with respect to left ventricular ejection fraction in patients with ST-elevation myocardial infarction undergoing percutaneous coronary…
- Trial name
- REVIVAL-3 (NCT00390832)
- Testing
- Erythropoietin
- Where
- 2 sites in Germany
- Volunteers
- 138 people
- Sponsor
- Deutsches Herzzentrum Muenchen
ST Segment Elevation Myocardial Infarction
Microvascular Dysfunction in Acute Myocardial Infarction (AMI) and Its Relation to Outcome
The purpose of this study is first to evaluate absolute myocardial blood flow and resistance over time in the acute and sub-acute phase of myocardial infarction and second, to correlate these parameters to preservation of left…
- Trial name
- NCT01538303
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease
Pre-hOspital Evaluation of Chest Pain Patients With sUspected Non ST-segment eLevation myocARdial Infarction Using the HEART-score With a Troponin Point-of-care Test
Overcrowding in the emergency department is an increasing problem in hospitals worldwide. Point-of-care Troponin (POC cTn) testing combined with a well investigated risk stratification tool (HEART-score) used in the ambulance may…
- Trial name
- POPular HEART (NCT04851418)
- Testing
- Possible NSTE-ACS
- Where
- 2 sites in Netherlands
- Volunteers
- 650 people
- Sponsor
- St. Antonius Hospital
Myocardial Infarction (MI)
Efficacy and Safety Study of Proposed Biosimilar Product Reveliza vs Actilise in Patients With ST-segment Elevation Myocardial Infarction
Thi is is a multi-center, randomized, single-blind, parallel group clinical trial to evaluate the efficacy and safety of the intravenious thrombolysis with Revelise® (GENERIUM, Russia) in comparosin with the Actilyse® (Boehringer…
- Trial name
- NCT07146360
- Testing
- Revelise (GENERIUM, Russia), Actilyse® (Boehringer Ingelheim Pharma GmbH and Co.KG, Germany)
- Where
- 22 sites in Russia
- Volunteers
- 180 people
- Sponsor
- AO GENERIUM
Essential Hypertension
Protective Effect of Beraprost Sodium Tablets on Reperfusion Therapy for Acute STEMI
Protective effect of Beraprost Sodium Tablets on coronary microcirculation function and ventricular remodeling after reperfusion therapy for acute ST segment elevation myocardial infarction
- Trial name
- NCT05103813
- Testing
- Beraprost Sodium Tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen People's Hospital
ST Elevation Myocardial Infarction
Ticagrelor Versus Clopidogrel in Left Ventricular Remodeling After ST-segment Elevation Myocardial Infarction
The purpose of the study is to evaluate the novel role of ticagrelor to improve long-term LV remodeling following ST-segment elevation myocardial infarction.
- Trial name
- HEALING-AMI (NCT02224534)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 12 sites in China, Singapore and 1 more
- Volunteers
- 326 people
- Sponsor
- Gyeongsang National University Hospital
Acute ST-segment Elevation Myocardial Infarction
Effect of Low-dose Intracoronary Reteplase on Myocardial Infarct Size During Primary Percutaneous Coronary Intervention
OBJECTIVE: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with reteplase infused after coronary reperfusion will reduce the myocardial infarction size.
- Trial name
- RECOVERII (NCT04571580)
- Testing
- Normal Saline, Reteplase Injection 9mg, Reteplase Injection 18mg
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Ge Junbo
Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction
An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is manifested in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world.
- Conditions
- Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction, Acute ST Segment Elevation Myocardial Infarction, Angina, Unstable
- Trial name
- DETO2X-AMI (NCT01787110)
- Testing
- Oxygen
- Where
- 34 sites in Sweden
- Volunteers
- 6,629 people
- Sponsor
- Karolinska Institutet
Left Ventricular Thrombus, ST Segment Elevation Myocardial Infarction
Rivaroxaban vErsus Warfarin for Antithrombotic TheRapy in Patients With LeFt Ventricular Thrombus After Acute STEMI
The purpose of the study is to assess the safety and efficacy of rivaroxaban-based versus warfarin-based antithrombotic regimens on outcomes of patients with left ventricle thrombosis following acute ST elevation myocardial…
- Trial name
- REWARF-STEMI (NCT05705089)
- Testing
- Rivaroxaban 15 MG, Warfarin
- Where
- 2 sites in Iran
- Volunteers
- 50 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Unstable Angina, Myocardial Infarction
Early Versus Delayed Timing of Intervention in Patients With Acute Coronary Syndromes
The timing of intervention study is a prospective, randomized, international, multicentre comparison of the relative efficacy, safety, and cost effectiveness of a management strategy of coronary angiography and intervention…
- Trial name
- TIMACS (NCT00552513)
- Testing
- Early Coronary Intervention, Delayed Coronary Intervention
- Where
- Canada
- Volunteers
- 3,031 people
- Sponsor
- Population Health Research Institute