Clinical trials: Segment Elevation Myocardial Infarction (STEMI)
ST-segment Elevation Myocardial Infarction, Non ST-segment Elevation Myocardial Infarction
Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART
In this trial we test the hypothesis that PCI and bivalirudin is superior to heparin alone (according to local protocol) in reducing death, MI, and major bleeding in patients with NSTEMI or STEMI at 180 days (primary end point)…
- Trial name
- VALIDATE (NCT02311231)
- Testing
- bivalirudin, Heparin
- Where
- Sweden
- Volunteers
- 6,012 people
- Sponsor
- Uppsala University
Contrast-Induced Acute Kidney Injury in ST-Segment Elevation Myocardial Infarction, Contrast Induced AKI
The Effect of Hydration on the Prevention of CI-AKI in STEMI Patients Undergoing Primary PCI (Hydro-AKI Trial)
The goal of this clinical trial is to determine whether a structured oral hydration regimen reduces the incidence of contrast-induced acute kidney injury (CI-AKI) in patients with ST-segment elevation myocardial infarction…
- Trial name
- Hydro-AKI (NCT07761754)
- Testing
- oral hydration protocol
- Volunteers
- 384 people
- Sponsor
- Assiut University
STEMI, Cardiovascular Disease
Vascular Healing After Implantation of FANTOM Bioresorbable Scaffold in STEMI: A FANTOM STEMI Study
The study will assess the safety and performance of the Fantom sirolimus eluting bioresorbable vascular scaffold (BVS) in the acute setting of myocardial infarction with unstable lesions and thrombogenic milieu.This is a…
- Conditions
- STEMI, Cardiovascular Disease, Bioresorbable Scaffold
- Trial name
- FANTOM STEMI (NCT03785431)
- Testing
- PCI with Phantom Bioresorbable Scaffold
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Vascular Diseases, Cardiovascular Diseases
The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction)
The purpose of this study is to test the hypothesis that the intracoronary transplantation of autologous mononuclear and CD 133 + bone marrow cells will improve left ventricular contractile function and will reduce the combined…
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- ESTABOMA (NCT01748383)
- Testing
- Transplantation of BMMCs, Transplantation of CD 133+ cells, stenting of IRA
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Russian Academy of Medical Sciences
Acute Coronary Syndrome
Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy
Primary Objective: To demonstrate the superior efficacy (composite of all-cause death + Myocardial Infarction (MI)) of Otamixaban to Unfractionated Heparin (UFH) + Eptifibatide Secondary Objectives: To demonstrate the superior…
- Trial name
- TAO (NCT01076764)
- Testing
- Otamixaban, UFH, Eptifibatide
- Where
- 607 sites in United States, Argentina and 53 more
- Volunteers
- 13,220 people
- Sponsor
- Sanofi
Myocardial Infarction
Safety of Early Discharge Following Low Risk Myocardial Infarction
Objectives: The primary objective of this study is to evaluate the safety of an early discharge strategy in patients with low risk ST-elevation myocardial infarction (STEMI), treated with primary percutaneous coronary…
- Trial name
- EDAMI (NCT01868256)
- Testing
- early discharge (<72 h), Conventional discharge
- Where
- Spain
- Volunteers
- 1,558 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Myocardial Infarction With ST Elevation, Anterior Wall Myocardial Infarction
Deferred Stenting in Patients With Anterior Wall STEMI
Trial Name) Impact of Immediate SteNt ImplaNtatiOn Versus Deferred Stent ImplAntaTION on Clinical Outcomes in Patients with AnteRior Wall ST-segment Elevation Myocardial Infarction (INNOVATION-CORE) Objectives) To evaluate the…
- Trial name
- INNOVATIONCORE (NCT03744000)
- Testing
- Immediate stenting, Deferred stenting
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Korea University Anam Hospital
Myocardial Infarction, Heart Failure
Henagliflozin Reducing Infarct Size After Priamry PCI in Patients With ST Segment Elevation Myocardial Infarction
This Randomized controlled intervention study recruited patients diagnosed with ST-segment elevation myocardial infarction (STEMI). A total of 240 patients were enrolled in either Henagliflozin group or control group.
- Trial name
- Health (NCT06187727)
- Testing
- Henagliflozin
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Qian geng
Anterior Myocardial Infarction
A Research Study to Evaluate the Safety and Preliminary Efficacy of SGC001 in Patients With Myocardial Infarction
The research study is being done to see if SGC001 can be used to treat people scheduled to undergo percutaneous coronary intervention for Anterior ST-segment Elevation Myocardial Infarction.
- Trial name
- NCT07091929
- Testing
- SGC001
- Where
- 4 sites in China
- Volunteers
- 38 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI)
Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone
In patients with a myocardial infarction (MI) treated medically alone, the objective of the PANTHEON trial is to evaluate if ticagrelor monotherapy reduces bleeding events, without an increase in patient-oriented ischemic events…
- Conditions
- NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI), Myocardial Infarction
- Trial name
- PANTHEON (NCT07257198)
- Testing
- Ticagrelor + aspirin
- Where
- Canada
- Volunteers
- 2,570 people
- Sponsor
- Montreal Heart Institute
Non ST Segment Elevation Myocardial Infarction, Unstable Angina
Patients With High-risk Acute Coronary Syndrome Without ST-segment Elevation
This non-inferiority study aims at comparing Versa® to the reference enoxaparin (Clexane®, Sanofi-Aventis) in patients with high-risk unstable angina and NSTEMI.
- Trial name
- VECOR (NCT01356992)
- Testing
- Enoxaparin
- Where
- 5 sites in Brazil
- Volunteers
- 62 people
- Sponsor
- Eurofarma Laboratorios S.A.
Acute Coronary Syndrome, STEMI
EKG Criteria and Identification of Acute Coronary Occlusion
The objective of this research study is to test the accuracy of preexisting criteria versus expert interpretation for the diagnosis of acute coronary occlusion (major heart attack due to a completely blocked blood vessel).
- Conditions
- Acute Coronary Syndrome, STEMI, STEMI - ST Elevation Myocardial Infarction, Acute Coronary Artery Thrombosis (Diagnosis)
- Trial name
- NCT03863327
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stony Brook University
ST-Segment Elevation Myocardial Infraction
IK-1001 (Sodium Sulfide (Na2S) for Injection) in Subjects With Acute ST-Segment Elevation Myocardial Infarction
Myocardial Infarctions (MI) are commonly known as heart attacks. An ST-Segment Elevation Myocardial Infarction (STEMI) is a more severe type of heart attack.
- Trial name
- NCT01007461
- Testing
- Sodium Sulfide (Na2S) for Injection
- Sponsor
- Mallinckrodt
ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus
Effect of Dapagliflozin in Myocardial Fibrosis and Ventricular Function in Patients With a ST-segment Elevation Myocardial Infarction
The DAPA-STEMI trial investigates whether dapagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), reduces heart muscle scarring (fibrosis) and improves heart function after a ST-segment elevation myocardial infarction…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus, Heart Failure, Myocardial Fibrosis
- Trial name
- DAPA-STEMI (NCT06619600)
- Testing
- Dapagliflozin
- Where
- 2 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Hospital Clinic of Barcelona
Myocardial Infarction
Intracoronary Darbepoetin-alpha to Reduce The Infarct Size and Post-Infarct Remodeling
Prospective, randomized and open label trial Hypothesis Infusion of intracoronary darbepoetin-alpha at the time of reperfusion may reduce infarct size and post-infarct pathologic left ventricular remodeling in patients with…
- Trial name
- NCT01538771
- Testing
- Darbepoetin alfa, Control Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Myocardial Infarction
Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI
OBJECTIVE: to evaluate the safety and efficacy of a brief intracoronary infusion of ADO applied at the time of reperfusion to limit infarct size and LV remodelling in patients with ACSST submitted to primary ACTP.
- Trial name
- PROMISE (NCT00781404)
- Testing
- Adenosine
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- David Garcia-Dorado
ST-segment Elevation Myocardial Infarction (STEMI)
Prolonged Clinical Follow-up of OPTIMA-5
The OPTIMA-5 trial is a prospective, multi-center, randomized, patient blinded, controlled trial comparing a single bolus of half-dose recombinant staphylokinase (r-SAK) with normal saline (NS) in patients with ST-segment…
- Trial name
- NCT05649696
- Testing
- Recombinant Staphylokinase, Normal Saline
- Where
- 8 sites in China
- Volunteers
- 210 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Vagus Nerve Stimulation, Acute Coronary Syndrome
Auricular Vagus Stimulation and STEMI
At the moment, the invasive strategy for the infarct-associated coronary artery in patients with ST-segment elevation myocardial infarction (STEMI) necessary to save the myocardium and reduce the size of the necrosis zone remains…
- Conditions
- Vagus Nerve Stimulation, Acute Coronary Syndrome, Ischemia Reperfusion Injury
- Trial name
- NCT05992259
- Testing
- TENS
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
ST Segment Elevation Myocardial Infarction
Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction
The primary objective of this study is to determine if the Smartphone electrocardiogram (ECG) is an acceptable replacement for a standard ECG in the identification of ST Elevation Myocardial Infarction (STEMI).
- Trial name
- ST LEUIS (NCT02498405)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Intermountain Health Care, Inc.
Triggers of Acute Myocardial Infarction, Time of Onset of Acute Myocardial Infarction
Myocardial Infarction Triggers and Onset in Jordan Study 2
A previous study (MINTOR 1) found that 43% of ST elevation myocardial infarction (STEMI) patients in Jordan had a triggering events.
- Conditions
- Triggers of Acute Myocardial Infarction, Time of Onset of Acute Myocardial Infarction, Long-term Prognosis After Acute Myocardial Infarction
- Trial name
- MINTOR 2 (NCT05992012)
- Where
- Jordan
- Volunteers
- 1,000 people
- Sponsor
- Jordan Collaborating Cardiology Group