Clinical trials: Segmentation
Macular Holes
Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery
Spectral domain optical coherence tomography (SD-OCT) was used to determine whether the repair of photoreceptor cone outer segment tips defect is significantly correlated with the visual outcomes after macular hole surgery.
- Trial name
- NCT01381965
- Testing
- Vitreous surgery for macular hole
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Kyorin University
Myocardial Infarction
Safety and Feasibility of Using a Single Transradial Guiding Catheter for Primary PCI
The Rapid Trial is a randomized-controlled trial proposed to test the hypothesis that using a single guiding catheter for left and right coronary angiography and intervention in patients with ST elevation myocardial infarction…
- Trial name
- RAPID (NCT01759043)
- Testing
- guiding catheter, diagnostic catheter
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Beijing Luhe Hospital
Myocardial Infarction
Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI
The purpose of this study is to determine which from the four combinations tirofiban+sirolimus eluting stent (SES), tirofiban+bare metal stent (BMS), abciximab+SES, abciximab+BMS is the possible gold standard treatment for…
- Trial name
- NCT00229515
- Testing
- abciximab followed by implantation of bare metal stent, abciximab and Sirolimus eluting stent, tirofiban and bare metal stent
- Where
- Italy
- Volunteers
- 744 people
- Sponsor
- Marco Valgimigli
Primary Pterygium, ASOCT, Conjunctival Autograft Surgery
Sutureless Glueless Technique Versus Interrupted Suturing for Conjunctival Autograft Fixation After Primary Pterygium Excision: Anterior Segment Optical Coherence Tomography (ASOCT) Study
This study aims to compare the clinical and Anterior segment optical coherence tomography (ASOCT) outcomes between sutured and sutureless conjunctival autograft fixation techniques in the management of primary pterygium.
- Trial name
- ASOCT (NCT07307820)
- Testing
- sutured conjunctival autograft fixation, Sutureless Conjunctival Autograft Fixation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pain
Omnitram Pharmacokinetic and Analgesic Study Following CY2D6 Inhibition With Paroxetine In Healthy Volunteers
This study evaluates the analgesic effect of Omnitram and tramadol during concurrent administration of paroxetine. Paroxetine administration is expected to diminish the analgesic effect of tramadol, but not Omnitram.
- Trial name
- NCT03312777
- Testing
- Omnitram, Tramadol
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Syntrix Biosystems, Inc.
Out-of-Hospital Cardiac Arrest, Hypothermia
Early Coronary Angiography Versus Delayed Coronary Angiography
This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment…
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypothermia, Cardiac Arrest
- Trial name
- PEARL (NCT02387398)
- Testing
- Early Angiography
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 99 people
- Sponsor
- University of Arizona
Endovascular Therapy, Acute Ischemic Stroke
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
RESCUE-M2O trial is a prospective, open label, blinded endpoint (PROBE), two-arm, randomized, controlled, post-market study to assess the efficacy and safety of endovascular therapy for acute ischemic stroke with occlusion of the…
- Conditions
- Endovascular Therapy, Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
- Trial name
- NCT07347665
- Testing
- Endovascular therapy
- Where
- 3 sites in Japan, Thailand and 1 more
- Volunteers
- 200 people
- Sponsor
- Hyogo Medical University
Vertebral Fracture, Cement Augmentation
Assessing Cement-bone Incorporation and Adjacent Segment Degeneration Following Cement Augmentation; an MRI-PET Follow-up
3-year PET-MRI follow-up after vertebral balloon kyphoplasty aiming to investigate cement incorporation.
- Trial name
- NCT03369288
- Testing
- PET MRI
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
ST Elevation Myocardial Infarction, HF - Heart Failure
Diagnostic Values of Galectin-3, Soluble ST2 and BNP in Predicting the Clinical Outcome of ST-Segment Elevation Myocardial Infarction Patients
An acute ST-elevation myocardial infarction occurs due to occlusion of one or more coronary arteries, causing transmural myocardial ischemia which in turn results in myocardial injury or necrosis.
- Conditions
- ST Elevation Myocardial Infarction, HF - Heart Failure, Stable Angina
- Trial name
- NCT05246215
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
ST-segment Elevation Myocardial Infarction (STEMI)
Evaluate Early Invasive Strategy for Patients With STEMI Presenting 24-48 Hours From Symptom Onset
The primary objective of the trial is to evaluate the efficacy of early invasive strategy for STEMI patients within 24-48h of symptom onset.
- Trial name
- NCT04962178
- Testing
- Primary PCI, Optimal medical therapy with primary PCI not performed
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Shanghai Zhongshan Hospital
Orthodontic Anchorage Procedures
Posterior Segment Intrusion Using Miniplates
Treating hyperdivergent malocclusion accompanied by open bite could be challenging and may be done by several methods as high pull headgear and posterior bite planes or surgically by maxillary impaction in adults.
- Trial name
- NCT02674191
- Testing
- mini-plates supported molar intrusion, Application of ULTRACARE benzocaine 20%,, Administration of , Mepivacaine-l
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Manal El Namrawy
Glaucoma, Glaucoma Following Surgery
Anterior-segment OCT (AS-OCT) and Intraoperative OCT (iOCT) for Trans- Conjunctival Needle Revision (TCNR)
Trabeculectomy is a very important and commonly performed glaucoma operation. It allows fluid from inside the eye to exit into a space called a bleb located on the surface of the eye under the upper eyelid.
- Trial name
- NCT05790408
- Testing
- Digital microscope integrated with intraoperative OCT (Zeiss Artevo 800, Carl Zeiss Meditec AG), Spectralis Anterior-segment OCT (AS-OCT) (Heidelberg Engineering)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
ST Segment Elevation Myocardial Infarction, Myocardial Oedema
Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart.
- Trial name
- NCT01897350
- Testing
- Cardiac magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Elisa McAlindon
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in STEMI and MVD (OPTION-STEMI)
Patients with STEMI (ST-segment elevation myocardial infarction) with multivessel disease which have PCI (percutaneous coronary intervention)-suitable non-IRA (infarct related artery) will be randomized to immediate complete…
- Trial name
- NCT04626882
- Testing
- Staged in-hospital or Immediate complete revascularization
- Where
- 14 sites in South Korea
- Volunteers
- 994 people
- Sponsor
- Chonnam National University Hospital
Degenerative Scoliosis
Clinical Study of Imaging and Endoplant-related Mechanical Complications After Long Segment Fixation and Fusion of Degenerative Lumbar Scoliosis (DLS)
There is a high probability of mechanical complications in patients with degenerative lumbar scoliosis after long segment fixation and fusion, and there are few studies on distal borderline kyphosis deformity/failure.
- Trial name
- NCT04960423
- Testing
- Long Segment Fixation and Fusion
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Neurotrophic Ulcer, Neurotrophic Keratitis
OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate
Neurotrophic keratitis (NK) is a condition where the cornea, or clear outer covering of the eye, has reduced sensation due to a variety of reasons.
- Conditions
- Neurotrophic Ulcer, Neurotrophic Keratitis, Neurotrophic Corneal Ulcer, Neurotrophic Keratoconjunctivitis
- Trial name
- NCT04573647
- Testing
- Cenegermin-Bkbj 0.002% Ophthalmic Solution [OXERVATE]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sight Medical Doctors PLLC
Glaucoma, Narrow Angle
Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs
The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0.1% vs. 0.2% after laser peripheral iridotomy (LPI).
- Trial name
- NCT01417858
- Testing
- YAG laser peripheral iridotomy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal do Paraná
Thoracolumbar Spine Fracture, Facet Joint Degeneration
Degenerative Changes After Treatment of Thoracolumbar Junction Fractures
This observational study will evaluate how degenerative changes in the facet joints and intervertebral discs develop over time after treatment of AOSpine type A2, A3, and A4 fractures of the thoracolumbar junction.
- Conditions
- Thoracolumbar Spine Fracture, Facet Joint Degeneration, Intervertebral Disc Degeneration
- Trial name
- NCT07672184
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sklifosovsky Institute of Emergency Care
NSTEMI - Non-ST Segment Elevation MI, Multi Vessel Coronary Artery Disease
Culprit Lesions in NSTEMI With Multi Vessel Disease (NSTEMI-CULPRIT)
Acute myocardial infarction owes to a plaque rupture resulting in total (STEMI) or partial occlusion (NSTEMI) of the coronary artery.
- Trial name
- NS-CULPRIT (NCT03479593)
- Testing
- CMR and OCT in NSTEMI patients with MVD
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-infectious Uveitis
Ozurdex® in Patients With Non-infectious Uveitis Affecting the Posterior Segment of the Eye
This observational study will evaluate the safety, efficacy, characteristics of patients, characteristics of physicians and quality of life in patients who are prescribed OZURDEX® as treatment for non-infectious uveitis of the…
- Trial name
- Louvre 2 (NCT02951975)
- Testing
- dexamethasone intravitreal implant
- Where
- 21 sites in France
- Volunteers
- 246 people
- Sponsor
- Allergan
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