Clinical trials: Seizure, Epileptic
Epilepsy
Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment…
- Trial name
- EPI-OPM (NCT07281222)
- Testing
- MEG OPM, MEG SQUID
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Generalized Tonic-clonic Seizures
An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures
The investigators will provide Levetiracetam treatment to epilepsy subjects in Japan who are judged to benefit from continued treatment with Levetiracetam by the investigators and who are willing to continuously receive this drug.
- Trial name
- NCT01398956
- Testing
- Levetiracetam
- Where
- 32 sites in Japan
- Volunteers
- 44 people
- Sponsor
- UCB Pharma
Epilepsy in Children, Sleep Disorder
Advanced EEG Technology in Childhood Epilepsy
A lot of effort has already been put into the development of smaller, wearable and more user-friendly devices to monitor seizures in patients with epilepsy.
- Trial name
- PnP (NCT04584385)
- Testing
- EEG
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy, Seizure
Epileptiform Potential of Fully Immersive Virtual Reality
The goal of this interventional study is to determine if the use of virtual reality headsets results in an increased risk of seizure in adolescent and adult individuals with epilepsy.
- Trial name
- NCT07451093
- Testing
- Virtual Reality Headset, display off, Virtual Reality Headset, Display only, Virtual Reality Headset, Display and Hand Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Epilepsy
Stress Management Intervention for Living With Epilepsy (SMILE)
The study will examine whether a stress reduction intervention reduces the number of seizures in people with drug resistant epilepsy.
- Trial name
- SMILE (NCT01444183)
- Testing
- Progressive muscle relaxation
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- Montefiore Medical Center
Epilepsies, Partial
Evaluation of Efficacy and Safety of OXC XR as Adjunctive Therapy for Partial Seizures
Evaluation of the safety and efficacy of Oxcarbazepine XR as adjunctive treatment for adults with partial onset seizures
- Trial name
- PROSPER1 (NCT00772603)
- Testing
- 2400mg SPN-804, 1200mg SPN-804
- Where
- 71 sites in United States, Bulgaria and 6 more
- Volunteers
- 366 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Epilepsy, Temporal Lobe
A Deep Learning Framework for Pediatric TLE Detection Using 18F-FDG-PET Imaging
This study aims to use radiomics analysis and deep learning approaches for seizure focus detection in pediatric patients with temporal lobe epilepsy (TLE).
- Trial name
- NCT04169581
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994
Study is conducted to evaluate the long-term safety and tolerability of lacosamide (LCM) in patients receiving LCM in SP0994 [NCT01465997].
- Trial name
- NCT02582866
- Testing
- Lacosamide
- Where
- 46 sites in Bulgaria, Finland and 13 more
- Volunteers
- 106 people
- Sponsor
- UCB Biopharma S.P.R.L.
Epilepsy
Characterization of Epilepsy Patients BEEP 2b
Some epilepsy patients are described as GB when they have worsened seizures or side effects related to switching between brand name and generic, or between generic antiepileptic drug (AED) products.
- Trial name
- BEEP2b (NCT02707965)
- Testing
- Oxcarbazepine (brand name vs generic drugs), Divalproex Sodium (brand name vs generic drugs), Carbamazepine (brand name vs generic drugs)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Food and Drug Administration (FDA)
Seizure Disorder, Partial
To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.
To evaluate long-term safety and efficacy of pregabalin in patients with partial seizures.
- Trial name
- NCT00141245
- Testing
- Pregabalin
- Where
- 46 sites in Australia, Austria and 11 more
- Volunteers
- 325 people
- Sponsor
- Pfizer
Epilepsy With Uncontrolled Focal-onset Seizures
REACH: RWE Retrospective Study to Evaluate Cenobamate Impact on Health Care Resource Utilization
The Study is an observational, retrospective study which aim is to assess cenobamate's healthcare resources utilization (HCRU) in the management of uncontrolled focal onset seizures.
- Trial name
- NCT06922175
- Where
- 10 sites in Germany, Netherlands and 3 more
- Volunteers
- 200 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Epilepsy, Intellectual Disability, Mild to Moderate
Ultra-long-term EEG Monitoring in PwID
Many people with intellectual disabilities (PwID) have seizures. Electroencephalography (EEG), which measures the brain's electrical activity, is a key method of diagnosing and assessing seizures but can be difficult and…
- Trial name
- NCT07385157
- Testing
- A minimally-invasive EEG monitoring device
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Plymouth
GNAO1, Dystonia
Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders
The goal of this clinical trial is to investigate feasibility and safety of an oral therapy with zinc in patients affected by Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) associated disorders.
- Conditions
- GNAO1, Dystonia, Epilepsy, Development Delay
- Trial name
- ZINCGNAO1 (NCT06412653)
- Testing
- Zinc Acetate Dihydrate
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- Children's University Hospital Cologne, Germany
Epilepsy, Absence
Does Body Positioning Affect the Yield of Hyperventilation in Routine Pediatric Electroencephalography - EEG Studies?
Children referred for routine EEG studies for suspected absence seizures will be asked, upon caregiver's informed consent, to perform 3 minutes of hyperventilation both in the supine position and while sitting up.
- Trial name
- NCT02766595
- Testing
- hyperventilation while sitting up during routine EEG
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Epilepsy
Genetics of Rolandic Epilepsy
The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.
- Trial name
- NCT00282854
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- King's College London
Epilepsy
Study of Speech Function in Epileptic Patients Based on Stereoelectroencephalography Signal
Based on stereoelectroencephalography model in the treatment of epilepsy patients, this study conducted language-related experimental studies without interfering with normal monitoring treatment.
- Trial name
- NCT05776745
- Testing
- Speech, Stereoelectroencephalography
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy; Seizure
Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy
This project studies how 2-deoxy-glucose (2DG) pills are absorbed and distributed in people with epilepsy. 2DG is similar to glucose, the main energy source for the brain, but it cannot be used as energy.
- Trial name
- NCT05605301
- Testing
- Oral 2-Deoxy-D-Glucose (2DG)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Virginia
Epilepsy With POS With or Without Secondary Generalization
Study to Look at How Effective Briviact is as add-on Treatment for Patients With Epilepsy With Partial Onset Seizures
Study is the first study after commercialization of brivaracetam. It is designed to collect real world information on the effectiveness of brivaracetam in patients with Partial Onset Seizure epislepsy who are treated in standard…
- Trial name
- BASE (NCT02687711)
- Where
- 44 sites in Denmark, Germany and 7 more
- Volunteers
- 544 people
- Sponsor
- UCB Biopharma S.P.R.L.
Epilepsy, Child, Only
The Effect of Levetiracetam on Lipid Profile in Children
Levetiracetam is a widely prescribed antiseizure medication in epileptic children due to an estimated better safety profile and easy accessibility.
- Conditions
- Epilepsy, Child, Only, Thyroid, Lipid Disorder
- Trial name
- NCT05276271
- Testing
- the blood sample test results
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Ege University
Epilepsy, Focal
A Study of Brivaracetam in Subjects With Partial Onset Seizures
This trial will evaluate the efficacy and safety of brivaracetam (at doses of 50 and 150 mg/day in twice a day administration) as add on therapy in subjects with focal epilepsy
- Trial name
- NCT00175929
- Testing
- Brivaracetam
- Where
- 56 sites in Belgium, Czechia and 7 more
- Volunteers
- 157 people
- Sponsor
- UCB Pharma
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