Clinical trials: Seizure
Epilepsies, Partial
Compassionate Use Program With Lacosamide in Patients With Partial-onset or Generalized Tonic-clonic Seizures
The objective of this Compassionate Use Program (CUP) is to provide continued access to Lacosamide (LCM) for monotherapy use for patients who were receiving LCM in SP0993 and SP0994 at the time of study unblinding and close of…
- Trial name
- NCT03559673
- Testing
- Lacosamide
- Sponsor
- UCB Biopharma S.P.R.L.
Seizures
Bioequivalency Study of Levetiracetam 1g Tablets Under Fed Conditions
The objective of this study was to prove the bioequivalence of Levetiracetam 1000 mg Tablets under fed conditions
- Trial name
- NCT00827320
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Seizures
Pediatric Dose Optimization for Seizures in Emergency Medical Services
The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study is designed to improve how paramedics treat seizures in children on ambulances.
- Trial name
- PediDOSE (NCT05121324)
- Testing
- Standardized seizure protocol, Conventional seizure protocol
- Where
- 20 sites in United States
- Volunteers
- 6,700 people
- Sponsor
- Stanford University
Traumatic Brain Injury, Post Traumatic Seizures
Pharmacological Management of Seizures Post Traumatic Brain Injury
The overall aim of the MAST trial is to define best practice in the use of anti-epileptic drugs (AEDs) for patients following a traumatic brain injury (TBI). The trial will consist of two parts.
- Trial name
- MAST (NCT04573803)
- Testing
- Phenytoin Sodium, Levetiracetam
- Volunteers
- 1,649 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Epilepsy, Status Epilepticus
Creation, Implementation, and Analysis of a Seizure Action Plan
Data strongly suggests that aggressive and early treatment of status epilepticus (SE) is crucial for seizure abortion and prevention of long-term neurologic sequelae.
- Trial name
- NCT02995759
- Testing
- Seizure Action Plan
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Neonatal Seizure
Neonatal Seizures in NICU of Assuit University Children's Hospital
A cross sectional study on neonatal seizures in Assuit University Children's hospital NICU.
- Trial name
- NCT05257889
- Testing
- blood and CSF studies + neuroimaging studies
- Volunteers
- 554 people
- Sponsor
- Assiut University
Epilepsy, Lennox-Gastaut Syndrome
A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
To evaluate the efficacy of GWP42003-P as adjunctive treatment in reducing the number of drop seizures when compared with placebo, in participants with Lennox-Gastaut Syndrome (LGS).
- Trial name
- GWPCARE4 (NCT02224690)
- Testing
- GWP42003-P 20 mg/kg/day Dose
- Where
- 24 sites in United States, Netherlands and 1 more
- Volunteers
- 171 people
- Sponsor
- Jazz Pharmaceuticals
Epileptic Seizures
Epidemiologic Follow Up Study of Newly Diagnosed Epilepsy Among Seniors
The purpose of this proposed research is to identify individuals in southeastern Arizona aged 65 years and older who have new onset seizures (or newly diagnosed epilepsy) and monitor them for at least two years.
- Trial name
- NCT01351727
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Arizona
CDKL5 Deficiency Disorder
Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder
A clinical study to evaluate the efficacy, safety, and tolerability of adjunctive ganaxolone therapy compared to placebo for the treatment of seizures in children and young adults with genetically confirmed CDKL5 gene mutation.
- Trial name
- Marigold (NCT03572933)
- Testing
- ganaxolone
- Where
- 36 sites in United States, Australia and 6 more
- Volunteers
- 101 people
- Sponsor
- Marinus Pharmaceuticals
Hearing Loss
Clinical Validation of the Lexie Lumen Hearing Aid
More than half a billion people globally have hearing loss. Most hearing loss is sensorineural, meaning that the hearing loss is irreversible and requires rehabilitation.
- Trial name
- NCT05337748
- Testing
- Lexie Self Test and Fit Group, Lexie Professional Test and Fit Group
- Where
- South Africa
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- hearX Group
Somatoform Disorders, Irritable Bowel Syndrome
Neurovegetative Decoupling in Somatoform Disorders : Biofeedback Interest
Evaluation of the physiological and clinical effects of the biofeedback training with patients suffering from somatoform disorders, depending on their neurovegetative profile related to a visceral-brain decoupling.
- Conditions
- Somatoform Disorders, Irritable Bowel Syndrome, Psychogenic Non-Epileptic Seizure
- Trial name
- BIOFEESOMATO (NCT04807933)
- Testing
- Heart rate variability Biofeedback [HRV-BFB]
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Grenoble
Neonatal Seizure, Neonatal Encephalopathy
A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures
The main purpose of this study is to determine the maximum safe tolerated dose of LEV in the treatment of neonatal seizures. Our hypothesis is that optimal dosing of Levetiracetam (LEV) to treat neonatal seizures is significantly…
- Conditions
- Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn
- Trial name
- NEOLEV3 (NCT05610085)
- Testing
- Levetiracetam Injection, Phenobarbital Sodium Injection
- Where
- 6 sites in United States, New Zealand
- Volunteers
- 133 people
- Sponsor
- University of California, San Diego
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Heart Arrest, Seizures
PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients.
- Conditions
- Heart Arrest, Seizures, Status Epilepticus
- Trial name
- PROSPER (NCT06401707)
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Francisco
Epileptic Encephalopathy, Childhood-Onset
Memantine for Epileptic Encephalopathy
This study will evaluate the potential benefit of memantine hydrochloride as treatment for children with epileptic encephalopathy using a double-blind placebo-controlled cross-over design.
- Trial name
- NCT03779672
- Testing
- Memantine Hydrochloride 10 mg
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Kenneth Myers, MD
Status Epilepticus
Ketamine in Refractory Convulsive Status Epilepticus
To evaluate the efficacy of intravenous administration of ketamine in the treatment of refractory convulsive status epilepticus in children compared to administration of midazolam at high doses, thiopental and / or propofol.
- Trial name
- KETASER01 (NCT02431663)
- Testing
- Ketamine
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Meyer Children's Hospital IRCCS
Newly Diagnosed Epilepsy With Focus on Seizure Frequency at Onset and Long-term Seizure Control
Predictive Value of Seizure Frequency at Onset for Long-Term Seizure Control
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, and achieving long-term seizure control remains a major therapeutic goal.
- Trial name
- NCT07343609
- Testing
- observational study (no intervention)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Epilepsy, Epilepsies, Partial
A Study of the Efficacy and Safety of Topiramate in the Treatment of Patients With Difficult to Control Epilepsy
The purpose of the study is to evaluate the effectiveness and safety of topiramate as add-on therapy in patients with difficult to control partial onset seizures who are taking one or two standard anti-epileptic drugs.
- Conditions
- Epilepsy, Epilepsies, Partial, Seizures
- Trial name
- NCT00236730
- Testing
- topiramate
- Volunteers
- 178 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Major Depressive Disorder
Comparative Effectiveness Clinical Trial of MST Compared to ECT in Major Depressive Disorder
This study was a prospective, open-label comparative effectiveness clinical trial, comparing magnetic seizure therapy (MST) to ECT in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT04216095
- Testing
- Electroconvulsive Therapy (n=30), Magnetic Seizure Therapy (n=30)
- Volunteers
- 60 people
- Sponsor
- Tanta University
Status Epilepticus, Seizure
EEG in In-hospital Patients With Seizure or Altered Mental State
In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Conditions
- Status Epilepticus, Seizure, Altered Mental Status
- Trial name
- NCT02383745
- Testing
- Acute EEG with fast EEG electrode
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital