Clinical trials: Seizure Disorder
Epileptic Seizures
Usefulness of Sodium MRI in the Presurgical Assessment of Drug-resistant Partial Epilepsy
Epilepsy is a common disease affecting 0.5 to 1% of the general population. Epilepsies refractory to drug treatment lead to increased morbidity, mortality and high costs for public health (representing 75% of the costs associated…
- Trial name
- EPISODIUM (NCT02304029)
- Testing
- MRI
- Where
- 4 sites in France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Temporal Lobe Epilepsy
Electrical Brain Stimulation to Reduce Epileptic Seizures
OBJECTIVES: About 15% of patients suffering from focal epilepsy are refractory to available pharmacological treatments. Until now, the only hope for such patients has been the development of new pharmaceutical treatments or…
- Trial name
- NCT00344877
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Epilepsy Intractable
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
The purpose of this pilot study is to measure adherence and quality of life in adults with intractable epilepsy following the Modified Atkins Diet (MAD) with Betaquik, a ready-to-use medium chain triglyceride (MCT) emulsion, as…
- Conditions
- Epilepsy, Epilepsy Intractable, Seizures, Seizure Disorder
- Trial name
- NCT03790436
- Testing
- Betaquik
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Epileptic Seizures
Epidemiologic Follow Up Study of Newly Diagnosed Epilepsy Among Seniors
The purpose of this proposed research is to identify individuals in southeastern Arizona aged 65 years and older who have new onset seizures (or newly diagnosed epilepsy) and monitor them for at least two years.
- Trial name
- NCT01351727
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Arizona
Epilepsy, Temporal Lobe
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures.
- Trial name
- NCT06483061
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Traumatic Brain Injury, Post-traumatic Epilepsy
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12…
- Trial name
- NCT05823766
- Testing
- In-Person Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Clinical Visit
- Where
- 9 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Epilepsy
A Study of Detection of Paroxysmal Events Utilizing Computer Vision and Machine Learning - Nelli
Nelli is a video-based non-EEG physiological seizure monitoring system. This study is a blinded comparison of Nelli's identified events to gold-standard video EEG review in at-rest pediatric subjects with suspected motor seizures.
- Trial name
- NCT05606575
- Testing
- Nelli
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Neuro Event Labs Inc.
Epilepsy
Supporting Treatment Adherence Regimens in Pediatric Epilepsy: The STAR Trial
Fifty-eight percent of children with new-onset epilepsy do not take their antiepileptic drugs (AEDs) as prescribed (i.e., non-adherence).
- Trial name
- NCT01851057
- Testing
- STAR, Education Only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Seizures, Hypoglycemia
Blood Sugars in Children With Idiopathic Seizures.
The purpose of this study is to determine if there is a significant percentage of children with the diagnosis of idiopathic seizures who have undiagnosed or unrecognized hypoglycemia (low blood sugar).
- Conditions
- Seizures, Hypoglycemia, Hyperammonemia
- Trial name
- NCT00279851
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Epilepsy, Tonic-Clonic
Embrace and Quality of Life
A prospective, open, randomized, pilot clinical trial which aims the assessment of quality of life (QOL) in epilepsy outpatients equipped with a wrist-worn biosensor that provides measures of electrodermal activity and…
- Trial name
- EMBQL (NCT03831802)
- Testing
- Embrace with Alert and Mate apps, Embrace with Mate app only
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lennox Gastaut Syndrome
Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut Syndrome
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of pallidothalamic tracts as adjunctive therapy for alleviating symptoms in Lennox-Gastaut Syndrome.
- Trial name
- PESL (NCT06464653)
- Testing
- Forel's Field H-DBS ON
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Liankun_Ren
Seizures, Epilepsies, Partial
Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.
To evaluate the efficacy and safety of diazepam in the management of refractory epilepsy in selected patients who require intermittent medical intervention for the control of episodes of acute repetitive seizures.
- Conditions
- Seizures, Epilepsies, Partial, Epilepsy, Complex Partial, Epilepsy, Generalized
- Trial name
- NCT00319501
- Testing
- Vanquix Auto-Injector (Diazepam Injection)
- Where
- 86 sites in United States
- Volunteers
- 234 people
- Sponsor
- Pfizer
Cardiac Arrest
Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims
Current guidelines recommend the use of sedatives and neuromuscular blocking agents to avoid shivering during therapeutic hypothermia in cardiac arrest victims.
- Trial name
- NCT01946802
- Testing
- Frontal 4 channel EEG
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Gil Joon Suh
Epilepsy
Study of Speech Function in Epileptic Patients Based on Stereoelectroencephalography Signal
Based on stereoelectroencephalography model in the treatment of epilepsy patients, this study conducted language-related experimental studies without interfering with normal monitoring treatment.
- Trial name
- NCT05776745
- Testing
- Speech, Stereoelectroencephalography
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
EEG@HOME (Phase 4 of the Project)
The goal of this project is the development of an EEG-cap (min. 21 electrodes) with user-friendly active dry electrodes that meets the expectations of the users regarding comfort and esthetics, without losing sight of the…
- Trial name
- NCT02394639
- Testing
- video-EEG monitoring
- Where
- 2 sites in Belgium
- Sponsor
- University Hospital, Ghent
Vaso-occlusive Crisis, Sickle Cell Disease
Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency Room
The management of pain in the emergency department is a major issue, especially for sickle cell patients who regularly consult for vaso-occlusive seizure (VOS).
- Trial name
- ReVCVO (NCT04756375)
- Testing
- Virtual Reality, Usual Care
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy
The main objective of the present study will be to establish whether a slow (within 160 days) or a rapid (within 60 days) withdrawal schedule of antiepileptic monotherapy influence relapse rate in adult patients with epilepsy…
- Trial name
- RASLOW (NCT05236166)
- Testing
- Rapid withdrawal of antiepileptic, Slow withdrawal of antiepileptic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University Magna Graecia
Epilepsy
Quality of Life Assessment in Patients With Epilepsy Using QOLIE-31
This observational study aims to assess quality of life in individuals with epilepsy using the Quality of Life in Epilepsy Inventory (QOLIE-31).
- Trial name
- NCT07449845
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Saglik Bilimleri Universitesi
Tuberous Sclerosis, Epilepsy
Clinical Trial Data Set Re-use With Statistical Methodologies Tailored for Clinical Trials in Rare Diseases
Tuberous sclerosis complex (TSC), affecting 1 in 6.000 live births, is characterized by the development of multisystem tumors. Seizures are frequent up to 80% of individuals.
- Trial name
- EPISTOPIDEAL (NCT05199402)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Imagine Institute