Clinical trials: Sense of Control
Primary Four Repeat Tauopathies (4RT), Corticobasal Syndrome (CBS)
Safety Study of TPI-287 to Treat CBS and PSP
The purpose of this study is to determine the safety and tolerability [maximum tolerated dose (MTD) within planned dosing range] of intravenous (IV) infusions of TPI 287 administered once every 3 weeks for 9 weeks (for a total of…
- Conditions
- Primary Four Repeat Tauopathies (4RT), Corticobasal Syndrome (CBS), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD)
- Trial name
- TPI-287-4RT (NCT02133846)
- Testing
- TPI 287 2 mg/m2, TPI-287 20 mg/m2, TPI-287 6.3 mg/m2
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Neck Pain
Virtual Reality in Chronic Neck Pain
The purpose of this study is to compare the effects of virtual reality, which encourages active neck movements, in individuals with chronic neck pain, with the control group receiving only neck exercises.
- Trial name
- NCT06549166
- Testing
- Experimental: VR and exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Koç University
Carpal Tunnel Syndrome
Very Low Frequency Magnetic Fields Versus the Supplement "Xinepa" in the Treatment of the Carpal Tunnel Syndrome
The purpose of the study is to determine the effectiveness of the treatment with very low frequency magnetic fields (ELF) on the reduction of pain and the relief of the associated signs such as sensitivity disorders that affect…
- Trial name
- NCT02891512
- Testing
- ELF, Xinepa®
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- University of Roma La Sapienza
Neuropathic Pain, Diabetes
Study to Evaluate the Efficacy and Safety of DS-1971a for the Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)
The hypothesis of this Phase 2 study is that at least 1 dose regimen of DS-1971a will demonstrate clinical superiority to placebo in managing pain associated with DPNP, and will be generally well tolerated.
- Trial name
- NCT02673866
- Testing
- DS-1971a, pregabalin
- Sponsor
- Daiichi Sankyo
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Obesity (Disorder), Bariatric Surgery
Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function
Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating…
- Trial name
- BariaGut Taste (NCT07268508)
- Testing
- Nutritional counseling
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Visual Impairments, Low Vision Digital Assistance
Effectiveness of a Multi-disciplinary Vision Rehabilitation Programme in Improving the Overall Quality of Life of Visually Impaired Adults
This trial compares multidisciplinary vision rehabilitation and vision rehabilitation services to determine which service works better at improving overall quality of life for adults with visual impairment.
- Conditions
- Visual Impairments, Low Vision Digital Assistance, Adults
- Trial name
- NCT07827040
- Testing
- Multidisciplinary vision rehabilitaion, Vision rehabilitation incorporating low vision training only
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- The Hong Kong Polytechnic University
Hearing Loss, Sensorineural
Quality Control of CE-Certified Phonak Hearing Aids - 2018_07
Phonak Hearing Systems pass through different development and study stages. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT03555084
- Testing
- Extension of Virto B-Titanium, Virto B-Titanium
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Sonova AG
Immunity, Cytokine Levels
Analysis of Psychoneuroimmunological Parameters of Health in Specific Population Groups in Slovakia
This study aims to investigate the links between psychological and biological immunity from the perspective of psychology, epidemiology, and immunology in a general population study sample as well as in a specific group of people…
- Conditions
- Immunity, Cytokine Levels, Psychological Adaptation, Resilience
- Trial name
- APNIP (NCT07070180)
- Where
- 3 sites in Slovakia
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Comenius University
Tinnitus, Subjective, Vagus Nerve Stimulation
Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus
This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen…
- Conditions
- Tinnitus, Subjective, Vagus Nerve Stimulation, Music Therapy, Double-Blind Method
- Trial name
- NCT05417711
- Testing
- Transcutaneous Vagus Nerve Stimulation Paired with Tailor-Made Notched Music Therapy, Tailor-made Notched Music Training
- Volunteers
- 388 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ankle Injuries, Balanced
Kinesio Taping Effects on Balance and Ankle Proprioception
Ankle injuries are among the most common musculoskeletal injuries, affecting both athletes and the general population. Various methods are used to prevent such injuries, but the effectiveness of different kinesio taping…
- Trial name
- NCT06832111
- Testing
- Kinesio Taping 1, Kinesio Taping 2
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Phantom Limb Pain, Phantom Pain
VR to Evaluate Phantom Limb Pain
The objective of this study is to develop a virtual rehabilitation system that can be used to effectively treat Phantom Limb Pain (PLP) within the research setting and for at-home use by individuals with upper and lower extremity…
- Conditions
- Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain
- Trial name
- NCT05915065
- Testing
- Coapt Phantom Limb Pain Management System
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Hearing Loss, Functional
A Self-Affirmation Intervention to Promote Hearing Aid Use
Hearing aids are the number one treatment for hearing loss and it is estimated that out of the 2 million of UK individuals who are supplied with hearing aids 1.4 million will use their hearing aids to varying degrees and the…
- Trial name
- NCT04382703
- Testing
- Self-Affirmation Exercise, Control
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cancer, Anorexia
Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study
To investigate delta-9-tetrahydrocannabinol's (THC) ability to increase food intake and improve food enjoyment for advanced cancer patients with taste and/or smell (chemosensory) abnormalities.
- Conditions
- Cancer, Anorexia, Taste Disorders, Olfactory Disorders
- Trial name
- NCT00316563
- Testing
- Marinol (Dronabinol)
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Alberta Health services
Age-related Macular Degeneration
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
This was a 64-week randomized, double-masked, multi-center, active-controlled, two-arm study in patients with neovascular age related macular degeneration (nAMD) who have not previously received anti- vascular endothelial growth…
- Trial name
- TALON (NCT04005352)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 118 sites in United States, Argentina and 18 more
- Volunteers
- 734 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
Effects of Different Concentric and Eccentric Muscle Fatigue Protocols on the Knee Joint Position Sense
The aim of this study was to investigate the effects of different concentric and eccentric muscle fatigue protocols on the knee joint position sense of healthy individuals.
- Trial name
- NCT06331221
- Testing
- Muscle fatigue Protocol
- Where
- Portugal
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Amputation
Movement and Sensation for Advanced Prosthetic Hands
The purpose of this study is to learn more information about nerves. This study is also designed to learn how the information in nerves could be used to develop new prosthetic devices.
- Trial name
- NCT03259386
- Testing
- Microelectrode array
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Age Related Hearing Loss, Deafness
A Clinical Trial of the Safety and Efficacy of TJ0113 Capsules in the Treatment of Patients With Age-related Hearing Loss
The purpose of this study is to explore the safety and efficacy of TJ0113 capsules in patients with age-related hearing loss.
- Trial name
- NCT07012746
- Testing
- TJ0113 capsules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yilai Shu
Pain, Peripheral Neuropathy
A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
The purpose of this study is to evaluate the efficacy of Sativex® compared with placebo in relieving peripheral neuropathic pain associated with allodynia.
- Trial name
- NCT00710554
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 246 people
- Sponsor
- Jazz Pharmaceuticals
Retinal Detachment, Metamorphopsia
Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula.
- Trial name
- REVEAL (NCT04158622)
- Testing
- PnR + laser/cryotherapy, PPV + laser/cryotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto