Clinical trials: Sensitization, Central
Knee Osteoarthristis
Femoral Nerve Mobilization for Patients With Knee Osteoarthritis
Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality.
- Trial name
- RCT (NCT07329205)
- Testing
- traditional physical therapy, Femoral nerve mobilization
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Fibromyalgia
Explain Pain in Fibromyalgia Patients
Education of pain physiology is described as an educational session or sessions describing the neurobiology and neurophysiology of pain, and pain processing by the nervous system.
- Trial name
- NCT02474875
- Testing
- Educational program
- Where
- 4 sites in Spain
- Volunteers
- 88 people
- Sponsor
- Cardenal Herrera University
Vitamin D Deficiency, Central Sensitisation
Central Sensitization in Vitamin D Deficiency
The purpose of this study is to investigate the presence of central sensitization in vitamin D deficiency and its effect on cutaneous silent period, pain, and quality of life.
- Trial name
- NCT03420378
- Testing
- vitamin D
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Marmara University
Central Sensitisation, Motor Disorders
Motor Unit Abnormalities After Experimentally Induced Sensitization
Central sensitization is a condition that represents a cascade of neurological adaptations, resulting in an amplification of nociceptive responses from noxious and non-noxious stimuli.
- Trial name
- NCT04361149
- Testing
- Capsaicin Topical Cream (0.075%), Delsys Trigno Galileo System, Excaliber, Natus Medical
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Toronto Rehabilitation Institute
Knee Osteoarthritis
tDCS for Pain Modulation in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common condition that causes long-lasting knee pain and difficulty with daily activities. Many patients have pain that is stronger than expected from joint changes because the nervous system becomes…
- Trial name
- KOA-tDCS (NCT07291791)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Suez Canal University
Lumbar Spinal Stenosis
Lumbar Spinal Stenosis and Central Sensitization
Lumbar spinal stenosis (LSS) functionally limits individuals by causing pain in both the waist and the legs during activity and walking. Pain is, therefore, an important problem for patients.
- Trial name
- NCT07001982
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Karabuk University
Fibromyalgia, Myofascial Pain Syndrome
Shock-Waves to Treat Fibromyalgia Pain
Fibromyalgia pain syndrome is a common debilitating condition which associates mainly generalised pain, emotional distress and cognitive symptoms. The etiology is unknown, and no specific treatment exists so far.
- Conditions
- Fibromyalgia, Myofascial Pain Syndrome, MSK: Chronic Pain Syndromes (E.G. Fibromyalgia), Central Sensitization
- Trial name
- SWPW-FPS (NCT03088215)
- Testing
- shock-waves
- Volunteers
- 40 people
- Sponsor
- Dr Yves JACOT, MD
Herniated Disc, Failed Back Surgery Syndrome
The Effect of Central Sensitization in Radicular Pain in Patients With Failed Low Back Surgery Syndrome
The Effect of Central Sensitization in Radicular Pain in Patients with Failed Low Back Surgery Syndrome on Treatment Success of Ultrasound-Guided Caudal Epidural Steroid Injection
- Trial name
- NCT06508918
- Testing
- Betametasona
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Marmara University
Widspread Chronic Pain, Fibromyalgia
The Effect of Vagus Nerve Stimulation on Pain and Functional Activities in Individuals With Chronic Widespread Pain
The goal of this clinical trial is to examine the effect of vagus nerve stimulation (VNS) on chronic, widespread pain in adults.
- Trial name
- NCT07080749
- Testing
- Vagal nerve stimulation through deep exhalation exercise, Vagal nerve stimulation through ear electrical stimulation, No intervention (observational study)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Georgia
Whiplash
Modern Pain Neuroscience Applied to Chronic Pain in Patients With Chronic Whiplash Associated Disorders
Modern pain neuroscience has advanced our understanding of chronic whiplash associated disorders (WAD). Previous studies have shown the importance of central sensitization, characterized by hypersensitivity of the somatosensory…
- Trial name
- NCT03239938
- Testing
- Modern pain neuroscience approach, Usual care evidence-based physiotherapy
- Where
- 3 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Vrije Universiteit Brussel
Osteo Arthritis Knee, Central Nervous System Sensitization
Pregabalin for Central Sensitization in TKA
The study purpose is to determine if giving pregabalin before and after total knee arthroplasty (TKA) can improve pain and meaningful function after surgery in patients that have central sensitization (CS).
- Trial name
- NCT05460871
- Testing
- Pregabalin 75mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Fibromyalgia, Interoception
The Role of Interoceptive Sensitivity in Central Sensitization Symptom Severity in Fibromyalgia
In fibromyalgia, the increased central sensitization symptom burden can lead to a disruption in the individual's interoception and difficulties in managing symptoms.
- Conditions
- Fibromyalgia, Interoception, Central Sensitization
- Trial name
- NCT07878286
- Testing
- Central Sensitization Inventory, The Multidimensional Assessment of Interoceptive Awareness scale-2, Revised Fibromyalgia Impact Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Osteo Arthritis Knee, Central Sensitisation
Central Sensitization in Knee Osteoarthritis
The stimuli that activate nociceptors cause the dorsal horn of the spinal cord neurons to be sensitive to low-intensive afferent stimuli by decreasing the excitation threshold in patients with osteoarthritis.
- Trial name
- NCT04308967
- Testing
- balance exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Chronic Low Back Pain
Assessment of Pain Perception and the Impact of Central Sensitization on Biopsychosocial Manifestations During Physical Activity in Patients With Chronic Low Back Pain
The goal of this prospective observational study is to evaluate changes in cognitive and behavioural markers associated with central sensitisation between the start and end of an exercise retraining programme on an exercise bike…
- Trial name
- BASICS (NCT07818551)
- Testing
- Exercise rehabilitation on an ergocycle
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Fibromyalgia, Chronic Pain
Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)
The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity)…
- Conditions
- Fibromyalgia, Chronic Pain, Nociplastic Pain
- Trial name
- PEARL (NCT07677631)
- Where
- 5 sites in Italy
- Volunteers
- 425 people
- Sponsor
- University of Bari
Covid19
poSt Covid-19 Infection centraL Sensitisation 2
The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection.
- Trial name
- SILENT 2 (NCT04701892)
- Testing
- Indicators of central sensitisation
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Lipedema, Central Sensitisation
Investigation of Central Sensitization and Associated Factors in Patients With Lipedema
This study aims to investigate the presence of central sensitization and its associated parameters in patients with lipedema. Lipedema is a chronic and hereditary condition that primarily affects the lower extremities in women…
- Trial name
- NCT06770634
- Testing
- Pain-Pressure Threshold Measurement With an Algometer, Central Sensitization Inventory, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Hyperalgesia
A Study Of GSK189254 And Duloxetine In The Electrical Hyperalgesia Model Of Healthy Volunteers
GSK189254 is a highly potent histamine 3 (H3) receptor antagonist which has demonstrated efficacy in the reduction of mechanical hyperalgesia and allodynia in the chronic constriction injury pre-clinical model of neuropathic pain…
- Trial name
- NCT00387413
- Testing
- Duloxetine, GSK189254
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Osteoarthritis
fMRI Evaluation of Pain Central Sensitization Phenomena in Subjects With Knee Osteoarthritis
The aim of this project is to investigate fMRI ability to identify pain central sensitization in chronic knee OA. Patients with high and low central sensitization and healthy control subjects will be included.
- Trial name
- NCT01700634
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Whiplash Associated Disorder (WAD)
Transauricular Vagus Nerve Stimulation for Chronic Whiplash Associated Disorders
Approximately 50% of people with chronic whiplash-associated disorders (WAD) continue to report the presence of symptoms 12 months post-injury.
- Trial name
- NCT07055373
- Testing
- Transauricular Vagal Nerve Stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary