Clinical trials: Sensitization, Central
Low Back Pain
Uterine Position and Pain and Central Sensitization Parameters in Women With Chronic Low Back Pain
Female patients aged 18-75 years with chronic low back pain (lasting at least 3 months) will be included in the study. Demographic data including age, height, weight, educational status, marital status, and comorbidities will be…
- Trial name
- NCT07549009
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Fibromyalgia
Pain Neuroscience Education and Physical Exercise Program in Fibromyalgia
This study evaluates the effects of a pain neuroscience education (PNE) and physical exercise (PE) program in women with fibromyalgia.
- Trial name
- NCT04539171
- Testing
- Pain Neuroscience Education and Physical Exercise
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Knee Osteoarthritis
Pain Compared Between the First and the Second Surgery in Staged BTKA
postoperative pain and analgesic consumption between the first and the second surgery would be compared in patients undergoing staged bilateral total knee arthroplasty (BTKA).
- Trial name
- NCT01457313
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Bundang Hospital
Chronic Pain, Persistent Pain
Pleasant Touch Perception in Persistent Pain.
The goal of this observational study is to learn how individuals with chronic pain experience pleasant touch and how often they are exposed to such touch in their daily lives.
- Trial name
- NCT07551687
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Chronic Pancreatitis, Pain Management
Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis
Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology.
- Trial name
- NEURO-CP (NCT07707609)
- Testing
- Comprehensive Neuropsychological Assessment, Resting-State Functional MRI (fMRI), Magnetic Resonance Spectroscopy (MRS)
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Migraine Disorders
Multi-Segmental Spinal Manual Therapy in Women With Episodic Migraine
The purpose of this study is to evaluate the clinical effects of multi-segmental spinal manual therapy on pain intensity, central sensitization (CS), and sensorimotor control in women diagnosed with episodic migraine (EM).
- Trial name
- NCT07774286
- Testing
- Multi-Segmental Spinal Manual Therapy
- Volunteers
- 10 people
- Sponsor
- Borna Farhoomand
Migraine
Validation of a Questionnaire for Allodynia in Migraine.
Migraine is very frequent (15% of the general population). During attacks, many subjects with migraine have allodynia (pain induced by normally non-painful stimuli), photophobia (hypersensitivity to light), phonophobia…
- Trial name
- Q-MIGAL (NCT04580641)
- Testing
- Questionnaire
- Where
- 14 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fibromyalgia (FM), Quantitative Sensory Testing
Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia
Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization.
- Conditions
- Fibromyalgia (FM), Quantitative Sensory Testing, Central Sensitization, PRESSURE PAIN THRESHOLD
- Trial name
- NCT07640607
- Testing
- Quantitative Sensory Tests(QST) protocol, Clinical Scales
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Hand Exercises for Rheumatoid Arthritis
Is a Standard Hand Rehabilitation Program Sufficient in Rheumatoid Arthritis Patients With Central Sensitization
The presence of central sensitization leads to overestimation of pain sensitivity and disease activity in rheumatoid arthritis (RA) patients.
- Trial name
- NCT07598240
- Testing
- Exercise1, Exercise2, Exercise3
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Fulya Coşkun
Chronic Neck Pain
Phrenic Nerve Infiltration in Neck Pain
Neck pain frequently present comorbidities in peridiaphragmatic organs. The innervation of these organs include the phrenic nerve. It is known that peridiaphragmatic organs trigger referred pain in the neck area.
- Trial name
- PAINOMICS (NCT05605639)
- Testing
- Bupivacaine
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Pelvic Girdle Pain, Chronic Pain
Exploring Central Sensitization in Pregnant Women
Pelvic Girdle Pain (PGP) is reported by 50% of pregnant women and up to 11 years after pregnancy, 10% of women have persistent and per definition chronic PGP.
- Trial name
- NCT05507853
- Where
- Sweden
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Low Back Pain, Low Back Pain, Recurrent
Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing
Although the cause of persistent non-specific low back pain (LBP) remains unknown, structural and functional alterations of the brain, alterations in the lumbar muscles and dysfunction of the central nervous system have been…
- Conditions
- Low Back Pain, Low Back Pain, Recurrent, Low Back Pain, Chronic, Healthy Volunteers
- Trial name
- B~Maps (NCT06143319)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Ghent
Fibromyalgia, Insomnia
Sleep and Pain Interventions in Women With Fibromyalgia
Insomnia affects 67-88% of chronic pain patients. SPIN II is a randomized controlled clinical trial that will compare the effects of two cognitive behavioral sleep treatments in women with fibromyalgia and insomnia.
- Conditions
- Fibromyalgia, Insomnia, Chronic Widespread Pain
- Trial name
- SPIN-II (NCT03744156)
- Testing
- Cognitive Behavioral Treatment-Insomnia, Sleep Hygiene Education
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Missouri-Columbia
Postoperative Pain, Breast Cancer Surgery
Postoperative Pain, Central Sensitization, and Sleep Quality in Breast Cancer Surgery Patients
This prospective observational study aims to investigate whether preoperative central sensitization and sleep quality are associated with acute postoperative pain levels in patients undergoing breast cancer surgery.
- Conditions
- Postoperative Pain, Breast Cancer Surgery, Central Sensitization, Sleep Quality
- Trial name
- NCT07077421
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Istanbul University - Cerrahpasa
Central Sensitisation, Migraine
Presence of Signs of Central Sensitization in Episodic and Chronic Migraine
Nowadays migraine is conceptualized as a continuum, with at the one hand episodic migraine (EM) and at the other hand chronic migraine (CM) (1).
- Trial name
- CENSENMI (NCT05162664)
- Testing
- Pressure pain thresholds, Thermal detection and pain thresholds, Temporal summation
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Ghent
Fibromyalgia
Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia
This is a Phase 3, multi-center, 52-week, open-label trial to evaluate the long-term safety and efficacy of AXS-14 in the management of fibromyalgia.
- Trial name
- NCT07637162
- Testing
- AXS-14 (esreboxetine)
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Axsome Therapeutics, Inc.
Fibromyalgia, Cognitive Dysfunction
Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and cognitive dysfunction in patients with fibromyalgia.The main questions it aims to answer are: Do central sensitization symptoms…
- Conditions
- Fibromyalgia, Cognitive Dysfunction, Central Sensitisation
- Trial name
- NCT06948903
- Testing
- Central Sensitization Inventory, The Montreal Cognitive Assessment, Cognitive Symptom Severity Scale-Extended
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Endometriosis, Central Sensitisation
Dyspareunia and Central Sensitization
Background: Endometriosis affects 10% of reproductive aged females, and can have a negative impact on sexual quality of life. Endometriosis can cause pelvic pain with deep penetration during intercourse, as well as other sexual…
- Conditions
- Endometriosis, Central Sensitisation, Dyspareunia
- Trial name
- NCT03216330
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- BC Women's Hospital & Health Centre
Fibromyalgia
Pain Neuroscience Education, Conditioned Pain Modulation and Emotional Processes in Fibromyalgia
Chronic pain represents a significant public health concern worldwide and is a primary reason why patients seek specialized medical care.
- Trial name
- NEUROPAINFIB (NCT07055971)
- Testing
- Experimental: Pain Neuoescience Education Group, Active Comparator: Biomedical Education Group
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidad de Granada
Lipedema
Pain, Central Sensitization, and Misophonia in Lipedema
Lipedema is a chronic condition that predominantly affects women and is characterized by disproportionate, usually symmetrical accumulation of subcutaneous fat, particularly in the hips and legs.
- Trial name
- NCT07849634
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital