Clinical trials: Sensitization, Central
Rheumatoid Arthritis
Central Aspects of Pain in Rheumatoid Arthritis
This study seeks to measure the psychometric properties of a newly developed Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, and investigate the ability of this questionnaire to measure central mechanisms…
- Trial name
- CAP-RA (NCT04515589)
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Nottingham
Neuropathic Pain
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
In animal, the GABAergic system modulates central sensitisation, which is a key phenomenon in pain processing. The development of GABAA agonists targeting the subunits of the GABAA receptor implicated in nociception, but not the…
- Trial name
- NCT01291316
- Testing
- Clonazepam, Tolterodine, clobazam
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Myofascial Pain, Physical Therapy
Myofascial Pain and Central Sensitization
This prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following…
- Trial name
- NCT04929171
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Low Back Pain, Chronic Low Back Pain
Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central Sensitization
The goal of this randomized controlled study is to evaluate the effectiveness of pain neuroscience education (PNE) combined with neuromuscular exercises (NME) in individuals with chronic low back pain and central sensitization…
- Conditions
- Low Back Pain, Chronic Low Back Pain, Central Sensitization
- Trial name
- NCT07866690
- Testing
- Pain Neuroscience Education, Neuromuscular Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Izmir Katip Celebi University
Adhesive Capsulitis of the Shoulder
Central Sensitization Presence on the Results of Shoulder Adhesive Capsulitis
Patients with adhesive capulitis longlasting more than 3 months were participated in the study. they were divided into two groups whether they have central sensitizaiton or not.
- Trial name
- FrozenShoulder (NCT07131839)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara City Hospital Bilkent
Fibromyalgia
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.
- Trial name
- FORWARD (NCT07398417)
- Testing
- AXS-14 (Esreboxetine)
- Where
- 53 sites in United States
- Volunteers
- 620 people
- Sponsor
- Axsome Therapeutics, Inc.
Systemic Lupus Erythematosus (SLE), Central Sensitization
Effectiveness of Resonance Frequency Breathing Exercises in Patients With Systemic Lupus Erythematosus and Central Sensitization
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by systemic inflammation, fatigue, central sensitization, and chronic pain.
- Conditions
- Systemic Lupus Erythematosus (SLE), Central Sensitization, Chronic Pain
- Trial name
- NCT07868289
- Testing
- Resonance Frequency Breathing, Standard Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Istanbul University - Cerrahpasa
Low Back Pain
Percutaneous Neuromodulation Therapy (PNT) With Chronic Low Back Pain Patients
The purpose of this study is to assess the benefits of Percutaneous Neuromodulation Therapy when compared to a reference sham treatment in the treatment of patients who have undergone surgical intervention for chronic low back…
- Trial name
- NCT00290238
- Testing
- Vertis Percutaneous Neuromodulation Therapy (PNT), Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- 8 sites in United States
- Volunteers
- 122 people
- Sponsor
- RS Medical
Pain
Rofecoxib to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of a new non-steroidal anti-inflammatory drug (NSAID) called rofecoxib to prevent pain following third molar (wisdom tooth) extraction.
- Trial name
- NCT00026819
- Testing
- Rofecoxib
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Chronic Non-specific Low Back Pain
Pain Neuroscience Education and Exercise for Chronic Nonspecific Low Back Pain
This study aims to evaluate the effects of adding Pain Neuroscience Education (PNE) to motor control exercises in individuals with chronic non-specific low back pain (CNSLBP) who also present with central sensitization.
- Trial name
- NCT07202533
- Testing
- Motor Control Exercises, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Carpal Tunnel Syndrome, Central Sensitisation
Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome
This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms.
- Conditions
- Carpal Tunnel Syndrome, Central Sensitisation, Pain, Radiating
- Trial name
- NCT07114913
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Osteoarthritis, Back Pain
Investigation of the Cultural Adaptation, Validity, and Reliability of the Turkish Version of the CAP Questionnaire
The "CAP questionnaire," developed by modifying the CAP-Knee questionnaire to assess potential nociplastic pain features in painful musculoskeletal disorders, has been described.
- Conditions
- Osteoarthritis, Back Pain, Fibromyalgia
- Trial name
- NCT06825650
- Testing
- Questionnaire study
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Hacettepe University
Chronic Cough
Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity
A cough lasting more than 2 months is known as a chronic cough, affecting 12-23% of the adult non-smoking population. Chronic cough has many associated complications including incontinence, muscular chest pains, blackouts and…
- Trial name
- NCT00858624
- Testing
- ketamine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jacky Smith
Central Sensitisation, Pain
Pain Processing In Relation To Breathing
The goal of this clinical trial is to investigate the effect of breathing on the processing of experimental pain in healthy participants. The main questions are: 1.
- Trial name
- NCT06169917
- Testing
- Paced Resonance Frequency Breathing, Paced Breathing at Natural Frequency, Heat Stimulations
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Chronic Pain, HIV
An Observational Study of Distress, Immune Function, and Pain in HIV.
This case-control study focuses on pain in HIV, which is common despite antiretroviral therapy and compromises quality of life, mental health and daily functioning.
- Conditions
- Chronic Pain, HIV, Distress, Emotional, Immune System and Related Disorders
- Trial name
- NCT04757987
- Testing
- Pain
- Where
- South Africa
- Volunteers
- 107 people
- Sponsor
- University of Cape Town
Central Sensitisation
Central Sensitization in Medical Students
Central sensitization (SS); is a physiological phenomenon caused by neuronal dysregulation and hyperexcitability in the central nervous system, resulting in hypersensitivity to painful and painless stimuli.Central sensitization…
- Trial name
- NCT05495594
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Dokuz Eylul University
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Central Nervous System Sensitization
Correlation Between Central Sensitization Inventory and Posturographic Data
To investigate the use of balance as a screening tool for Central Sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain.
- Trial name
- NCT03058003
- Testing
- Posturography Evaluation, Central Sensitization Inventory
- Where
- 2 sites in United States, Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Caps Research Network