Clinical trials: Sensitization, Central
Fibromyalgia, Chronic Pain
Effects of Photobiomodulation in a Population Suffering From Fibromyalgia
The development of an integral and global treatment to improve the quality of life in those with fibromyalgia syndrome (FMS) is challenging, thus a whole body Photobiomodulation (PBM) therapy program is proposed as an effective…
- Trial name
- NCT04248972
- Testing
- PBM
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Malaga
Hysterectomy, Chronic Pain
Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete…
- Conditions
- Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression
- Trial name
- EPOCH (NCT04014829)
- Testing
- Pain-Pressure Threshold, Mechanical Temporal Summation, Hospital Anxiety and Depression Scale
- Where
- Singapore
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Fibromyalgia
tDCS Combined With Therapeutic Exercise in Fibromyalgia Patients
The purpose of this study is to assess the effects on pain of transcranial direct current stimulation combined with therapeutic exercise in fibromyalgia patients.
- Trial name
- NCT04050254
- Testing
- Real tDCS, Therapeutic exercise
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Castilla-La Mancha
Fibroid Uterus, Pain, Postoperative
Pre-incisional Wound INfiltration and Hypogastric PLEXus Block Using Ropivacaine in Laparoscopic Myomectomy
The purpose of this study is to assess an impact of laparoscopic superior hypogastric plexus (SHP) block combined with preemptive troacar site infiltration on postoperative pain intensity following laparoscopic myomectomy.
- Trial name
- WINPLEX (NCT06429163)
- Testing
- Troacar site infiltration, Superior hypogastric plexus block
- Where
- Russia
- Volunteers
- 207 people
- Sponsor
- Saint Petersburg State University, Russia
Insomnia, Fibromyalgia
Sleep and Pain Interventions in Fibromyalgia
This is a single-center, randomized controlled trial study design. Enrolled participants had comorbid fibromyalgia and chronic insomnia.
- Trial name
- SPIN (NCT02001077)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Cognitive Behavioral Therapy for Pain (CBT-P)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University of Florida
Hemophilia
Central Sensitisation in Patients With Haemophilia and Degenerative Arthropathy
Introduction: Hemophilic arthropathy is characterized by functional impairments, disabling physical sequelae, and chronic pain. Central pain sensitization describes increased neural excitability characterized by spontaneous or…
- Trial name
- NCT07110675
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Myofascial Pain Syndrome - Neck
Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain
This study aims to investigate how closely two approaches to assessing pain-related characteristics agree in adults with chronic cervical myofascial pain syndrome (chronic neck pain associated with painful muscle trigger points).
- Trial name
- NCT07904364
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Mardin Artuklu University
Endometriosis, Chronic Pelvic Pain
Ketamine in Central Sensitization
The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA.
- Trial name
- NCT07182032
- Testing
- ketamine
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Temporomandibular Disorder, Central Sensitisation
Effects of Aerobic Exercise on Pain in Patients With Myogenous Temporomandibular Disorders and Suspicion of Central Sensitization
Temporomandibular disorders are common in the general population, the myogenic subtype being the most frequent. Central sensitization seems to be present in this pathology, with a decreased pain pressure threshold observed in…
- Conditions
- Temporomandibular Disorder, Central Sensitisation, Myofascial Pain Syndrome, Endurance Training
- Trial name
- NCT05540366
- Testing
- Physical therapy combined with aerobic exercise, Physical Therapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universitat Internacional de Catalunya
Endometriosis, Adenomatosis
The Influence of Central Sensitization in Endometriosis Disease
Endometriosis diseases include endometriosis and adenomyosis. Researchers will include 200 or more patients with endometriosis diseases; collect relevant clinical data such as age, BMI, educational level, history of other…
- Trial name
- NCT07014761
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Central Nervous System Sensitization, Pain
Effect of High-dose Naloxone Infusion on Pain and Hyperalgesia in Patients Following Groin-Hernia Repair.
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Central Nervous System Sensitization, Pain, Hyperalgesia
- Trial name
- NCT01992146
- Testing
- Target-controlled naloxone-infusion
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fibromyalgia (FM)
Exercise and Neuromodulation in Fibromyalgia
Exercise is recommended for people with fibromyalgia because it can reduce symptoms and improve quality of life. Some studies show that high-intensity exercises like running or cycling (also called high-intensity interval…
- Trial name
- NCT07323199
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Neuromodulators
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad Nacional Andres Bello
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Pelvic Floor Dysfunctions
Central Sensitization Inventory and Symptoms of Pelvic Floor Dysfunctions
The goal of this observational study is to assess the values of Central Sensitization Inventory in women in a gynecology outpatient clinic.
- Trial name
- NCT07154576
- Where
- Poland
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Żelazna Medical Centre, LLC
Complex Regional Pain Syndrome (CRPS)
Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome
Transcranial direct current stimulation (tDCS) is a non-invasive therapy increasingly used in facilities treating patients with chronic pain.
- Trial name
- ALGOSTIM (NCT07361692)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Polyclinique de l'Europe
Central Nervous System Sensitization, Peripheral Nervous System Disorders
Effects of Soft Tissue Treatment vs Mechanisms Explanation to Treat Delayed Onset Muscles Soreness Among Sport Climbers
The aim of the present research is to define the effects of short manual treatment of soft tissues compared to mechanisms explaining in Delayed Onset Muscle Soreness (DOMS) among sport climbers and to address the mechanisms of…
- Conditions
- Central Nervous System Sensitization, Peripheral Nervous System Disorders, Muscle Soreness, Muscle Strength
- Trial name
- NCT04255212
- Testing
- Soft tissue treatment, Mechaninsms explanation, Control Group
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Whiplash
Chronic Whiplash Associated Disorders: Disability, Pain (Beliefs), Central Sensitization and Brain Activity
This is a cross-sectional case-control study in which 70 patients with chronic whiplash associated disorders will be recruited and compared to 70 healthy pain-free controls.
- Trial name
- NCT04204525
- Testing
- Quantitative sensory testing
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Ghent
Central Sensitisation, Fibromyalgia
The Nociceptive Flexion Reflex as a Diagnostic Tool of Central Sensitization
This experimental study will investigate whether the decreased NFR threshold and increased NFR temporal summation, which are frequently observed in chronic pain patients, are only symptomatic manifestations that occur in the…
- Conditions
- Central Sensitisation, Fibromyalgia, Neck Pain, Low Back Pain
- Trial name
- NFR-CS (NCT05321550)
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Ghent
Tension-Type Headache
Signs of Central Sensitization in Tension-type Headache
The goal of this observational study is to assess the pain sensitivity in tension-type headache patients. The main question it aims to answer is: Are signs of central sensitization present in tension-type headache? Participants…
- Trial name
- CSTTH (NCT06323720)
- Testing
- Quantitative Sensory Testing
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- University Ghent
CBD, Healthy
CBD-Microglia PET Study
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects.
- Trial name
- NCT04398719
- Testing
- [11C]PBR28, Low-dose lipopolysaccharide, Intradermal Capsaicin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University