Clinical trials: Sensitization, Central
Familial Mediterranean Fever, Central Sensitisation
Central Sensitization in Familial Mediterranean Fever (FMF)
Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis.
- Trial name
- FMF (NCT05177120)
- Testing
- Central Sensitization Inventory, Short form-36, Pittsburgh Sleep Quality Index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Lateral Epicondylitis
Role of Cervical Spine Mobilization on Lateral Epicondylitis
The study's primary goal is to examine the effectiveness of Mulligan's technique in reducing hyperalgesia in lateral epicondylitis, focusing on cervical spine, while also investigating its influence on central sensitization in…
- Trial name
- NCT06271915
- Testing
- SNAGs - eccentric exercise
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Experimental Pain, Hyperalgesia
Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers
The aim of this study is to assess the anti-hyperalgesic effect of dextromethorphan in healthy volunteers compared to placebo.
- Trial name
- Hydex (NCT02596360)
- Testing
- Pulmodexane® 30mg, lactose
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Chronic Pain, Central Sensitisation
Reliability and Validity of the IASP Clinical Criteria for Identifying Patients with Nociplastic Pain
This protocol will report on the validation of IASP clinical criteria for indentifying nociplastic pain. The study will include 2 phases.
- Conditions
- Chronic Pain, Central Sensitisation, Nociplastic Pain
- Trial name
- NCT04730791
- Testing
- Algo(s)rithm/ IASP clinical criteria, Pressure Pain Threshold
- Where
- 2 sites in Greece
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Central Sensitization, Knee Osteoarthristis
Aquatic Exercise in Patients With Knee Osteoarthritis
The effect of aquatic exercise on central sensitization in patients with knee osteoarthritis are not fully known in the studies conducted to date.
- Conditions
- Central Sensitization, Knee Osteoarthristis, Aquatic
- Trial name
- NCT07883824
- Testing
- Standard physical therapy, Hydrotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Plantar Fasciitis, Chronic
Comparative Effectiveness of Different Neural Mobilization Techniques in Plantar Fasciitis
BThis study will be designed to compare between the effect of adding posterior tibial nerve or saphenous nerve mobilization to the traditional physical therapy on pain intensity, foot function, pressure pain threshold, ankle…
- Trial name
- RCT (NCT07657533)
- Testing
- nerve mobilization, physical therapy, saphenous nerve mobilization
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Chronic Pain, Adults 21 and Older
Efficacy of the Quell Wearable Device for Chronic Overlapping Pain Conditions
This study will examine the pain-relieving effects of a transcutaneous electrical nerve stimulator device called a Quell for persons with multiple chronic overlapping pain conditions.
- Conditions
- Chronic Pain, Adults 21 and Older, Multiple Chronic Overlapping Pain Conditions, Hypersensitivity
- Trial name
- NCT05540002
- Testing
- High Intensity Quell, Low Intensity Quell
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Brigham and Women's Hospital
Symptomatic Irreversible Pulpitis, Acute Apical Periodontitis of Pulpal Origin
The Effect of Central Sensitization on Assessment Capacity of Patients
the aim of this study is to evaluate the effect of dental hyperalgesia and mechanical allodynia on the assessment capacity of individuals in a local Turkish population.
- Trial name
- NCT03553641
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Hyperalgesia
Effect of Gabapentin on Pain of the Second Cataract Surgery
Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.
- Trial name
- NCT02127853
- Testing
- gabapentin
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Chronic Pain, Central Sensitisation
Clinical Trial on Deprescribing Associated With a Psychoeducational Program Using Virtual Reality for Patients With Chronic Pain and Central Sensitization
This clinical trial evaluates the effectiveness of the REDOCVR program, an interdisciplinary, psychoeducational intervention designed to support deprescribing of chronic pain medications in primary care.
- Conditions
- Chronic Pain, Central Sensitisation, Opioid-Related Disorders, Patient Empowerment
- Trial name
- REDOCVR_AC (NCT06964360)
- Testing
- REDOCVR Psychoeducational Program, Standard Educational Materials
- Where
- 4 sites in Spain
- Volunteers
- 174 people
- Sponsor
- Badalona Serveis Assistencials
Neck Pain, Migraine
Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study
Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life.
- Conditions
- Neck Pain, Migraine, Low Back Pain
- Trial name
- NCT07567300
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people
- Sponsor
- Bozok University
Whiplash Injuries
Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders
The primary study aim is to unravel the nature of impaired pain inhibition during exercise in patients with chronic Whiplash-Associated Disorders (WAD).
- Trial name
- NCT01601912
- Testing
- Atomoxetine, Citalopram
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Non-specific Chronic Low Back Pain, Central Sensitization
Exercise Interventions for Overweight Men With Chronic Low Back Pain
This randomized controlled trial aims to compare the effectiveness of motor control exercise, aerobic walking exercise, and muscle strengthening exercise in overweight male adults with non-specific chronic low back pain and…
- Trial name
- MAMS-CLBP (NCT07688564)
- Testing
- Motor Control Exercise, Aerobic Walking Exercise, Muscle Strengthening Exercise
- Where
- Saudi Arabia
- Volunteers
- 156 people
- Sponsor
- Universiti Sains Malaysia
Inflammatory Bowel Diseases, Chronic Pain
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
This study evaluates nervous system hypersensitivity in individuals with inflammatory bowel disease (IBD) and experiences of ongoing musculoskeletal (MSK) pain.
- Conditions
- Inflammatory Bowel Diseases, Chronic Pain, Central Sensitization
- Trial name
- NCT03799471
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Achilles Tendon Pain
Achilles Pain Block
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT).
- Trial name
- APB (NCT03316378)
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Chronic Pain
Immediate Effects of a 10-minute Body Scan Meditation on People Who Has Central Sensitization
For patients with chronic pain, how does a 10 minute guided body scan meditation affect pressure pain threshold and extent of pain on a body diagram?
- Trial name
- NCT05498077
- Testing
- Body scan meditation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Therapeutic Neuroscience Research Group
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Central Sensitization, Lipedema
The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study
The aim of this study is to evaluate the effect of metabolic markers (HOMA-IR, triglyceride/HDL ratio, HbA1c, waist and hip circumference measurements, BMI, etc.) on pain and central sensitization in patients diagnosed with…
- Conditions
- Central Sensitization, Lipedema, Pain, HOMA-IR
- Trial name
- NCT07468097
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Marmara University